Abstract: Due to the superior molecular recognition and good physical and chemical stability, the molecularly imprinted materials have gained more and more concern recently in extrication and separation fields. Using the imprinted materials as adsorbents, the molecularly imprinted solid-phase extraction (MISPE) allows selective extraction of the target molecules and its analogues from complex matrices, and is suitable for complex sample preparation and enrichment processes. This article describes the principle, latest progresses and parameters of molecularly imprinted solid-phase extraction and summarizes its extraction and applications for the determination of drug residues of animal source foods in recent years. Moreover, the shortcomings and future prospects of molecularly imprinted solid-phase extraction are also mentioned.

Key words: drug residue detection, animal source foods, applications, molecularly imprinted solid-phase extraction （MISPE）