色谱 ›› 2013, Vol. 31 ›› Issue (12): 1154-1160.DOI: 10.3724/SP.J.1123.2013.07014

• 专论与综述 • 上一篇    下一篇

液相色谱-质谱在阿尔茨海默病研究中的应用

田士军1, 彭向雷1, 郑妍鹏1, 何金生1, 洪涛1,2   

  1. 1. 北京交通大学生命科学与生物工程研究院, 北京 100044;
    2. 中国疾病预防控制中心病毒病预防控制所, 北京 100052
  • 收稿日期:2013-07-10 修回日期:2013-09-05 出版日期:2013-12-28 发布日期:2013-12-05
  • 通讯作者: 郑妍鹏,何金生
  • 基金资助:

    国家自然科学基金项目(21205004);中央高校基本科研业务费专项资金(2013JBM100,2012JBZ003);北京分子科学国家实验室开放课题基金项目

Application of liquid chromatography-mass spectrometry in the research of Alzheimer’s disease

TIAN Shijun1, PENG Xianglei1, ZHENG Yanpeng1, HE Jinsheng1, HONG Tao1,2   

  1. 1. College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China;
    2. Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
  • Received:2013-07-10 Revised:2013-09-05 Online:2013-12-28 Published:2013-12-05

摘要:

液相色谱-质谱联用(LC-MS)作为集高效分离与定性定量检测为一体的联用技术,近年来在化学、医学、药学和生物化学等领域获得了长足的发展,特别是由科研领域拓展到临床诊断,开启了疾病诊断技术的新篇章。阿尔茨海默病(Alzheimer’s disease,AD),又称老年性痴呆症,是现代社会第四大致死疾病。随着我国人口的快速老龄化,重视对AD的防治是实现健康老龄化以及国民经济持续发展的重要保障之一。本文对LC-MS的新进展进行了简介,并详细综述了近3年来其在AD研究中的应用,以期相关方法获得更好的理解与更多的关注。

关键词: 阿尔茨海默病, 临床化学, 液相色谱-质谱, 综述

Abstract:

Liquid chromatography-mass spectrometry (LC-MS) combining with both highly efficient separation and detection is widely applied to chemistry, medicine, pharmacy biochemistry etc. Particularly, the application of LC-MS to clinic chemistry opened a new chapter for diagnosis technologies. Alzheimer's disease (AD), also called as senile dementia, is the fourth leading cause of death in modern society. With the rapid aging of population, the prevention and treatment of AD need to be strengthened. In this review, we briefly introduce the new LC-MS developments and discuss the applications of LC-MS techniques in AD research in the last three years.

Key words: Alzheimer’s disease (AD), clinic chemistry, liquid chromatography-mass spectrometry (LC-MS), review

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