回归正交评价指标智能筛选法用于色谱分离条件的快速优化

doi:10.3724/SP.J.1123.2014.09040

摘要/Abstract

摘要：

建立了一种可用于色谱分离条件快速优化的回归正交评价指标智能筛选法。以串行色谱响应函数作为色谱条件优化指标,利用回归正交试验设计建立回归模型,并通过最优解智能筛选程序对综合性优化指标进行筛选,最终实现色谱分离条件的最优化。结果表明:实验测定值与预测值的平均相对偏差为0.18%,优化结果理想。

关键词: 串行色谱响应函数, 高效液相色谱法, 回归正交评价指标智能筛选法, 回归正交试验设计, 色谱条件的优化

Abstract:

This paper presents a method of regression evaluation index intelligent filter method (REIFM) for quick optimization of chromatographic separation conditions. The hierarchical chromatography response function was used as the chromatography-optimization index. The regression model was established by orthogonal regression design. The chromatography-optimization index was filtered by the intelligent filter program, and the optimization of the separation conditions was obtained. The experimental results showed that the average relative deviation between the experimental values and the predicted values was 0.18% at the optimum and the optimization results were satisfactory.

Key words: chromatographic condition optimization, hierarchical chromatography response function, high performance liquid chromatography (HPLC), orthogonal regression design, regression evaluation index intelligent filter method

中图分类号:

O658

甘伟, 刘学敏, 孙静. 回归正交评价指标智能筛选法用于色谱分离条件的快速优化[J]. 色谱, 2015, 33(2): 140-145.

GAN Wei, LIU Xuemin, SUN Jing. Regression evaluation index intelligent filter method for quick optimization of chromatographic separation conditions[J]. Chinese Journal of Chromatography, 2015, 33(2): 140-145.

参考文献

[1] Bian K, Lin T, Liu M, et al. Chinese Journal of Chromatography (卞愧, 林涛, 刘敏, 等. 色谱), 2014, 32(2): 162
[2] Wang D Y, Zhu J B, Ding Y, et al. Chinese Journal of Chromatography (王定颖, 朱靖博, 丁燕, 等. 色谱), 2014, 32(6): 604
[3] Qiao K L, Lü J. Journal of Yan'an University: Natural Science Edition (乔克林, 吕佳. 延安大学学报: 自然科学版), 2009, 28(2): 34
[4] Zhu W Y. Application of Orthogonal and Orthogonal Regression Method. Shenyang: Liaoning People's Publishing House (朱伟勇. 正交与回归正交试验法的应用. 沈阳: 辽宁人民出版社), 1978: 84
[5] Chen J S. Experimental Study on Metallurgical Methods. Beijing: Metallurgical Industry Press (陈建设. 冶金试验研究方法. 北京: 冶金工业出版社), 2005: 65
[6] Li Z Z. Chinese Journal of Spectroscopy Laboratory (李志洲. 光谱实验室), 2012, 29(5): 3047
[7] Gu Y Y. Computer Applications and Software (顾运筠. 计算机应用与软件), 2005, 22(1): 137
[8] Chen G Y, Le A P. Chinese Journal of Health Laboratory Technology (陈国员, 乐爱平. 中国卫生检验杂志), 2010, 20(10): 2518
[9] Yang L, Chen Y P. Mathematica Numerica Sinica (杨柳, 陈艳萍. 计算数学), 2008, 30(4): 388
[10] Shi L, Zhang Z W. Journal of Chinese Medicinal Materials (石磊, 张振巍. 中药材), 2011, 34(12): 1946
[11] Yu Y M, Wang J H, Zhang S Z, et al. Journal of Nanjing Forestry University: Natural Science Edition (于永明, 王军辉, 张宋智, 等. 南京林业大学学报: 自然科学版), 2011, 35(4): 47
[12] Xiao R F, Liu J Y, Zhang J Q. Technology of Water Treatment (肖入峰, 刘景洋, 张建强. 水处理技术), 2012, 38(6): 49
[13] Zhan F, Shao J, Han Y P. Food Science (战峰, 邵婧, 韩泳平. 食品科学), 2011, 32(16): 196
[14] Liu Z Q, Chen Y L. Journal of the Chinese Cereals and Oils Association (刘竹青, 陈有亮. 中国粮油学报), 2013, 28(2): 48
[15] Dong R, Tang M L, Wu Y X, et al. Xinjiang Agricultural Sciences (董瑞, 唐明磊, 吴玉霞, 等. 新疆农业科学), 2012, 49(4): 646
[16] Lu M, Tang H R, Yu S J, et al. Journal of Fruit Science (鲁敏, 汤浩茹, 余世杰, 等. 果树学报), 2011, 28(1): 171
[17] Yang J P, Liu Z G, Li M, et al. Hydrometallurgy of China (阳建平, 柳召刚, 李梅, 等. 湿法冶金), 2013, 32(1): 27
[18] Zou H F, Zhang Y K, Lu P Z. High Performance Liquid Chromatography. Beijing: Science Press (邹汉法, 张玉奎, 卢佩章. 高效液相色谱法. 北京: 科学出版社), 1998: 210
[19] Da S L. Introduction to Chromatography. Wuhan: Wuhan University Press (达世禄. 色谱学导论. 武汉: 武汉大学出版社), 1999
[20] Lu P Z, Zhang Y K, Liang X M. High Performance Liquid Chromatography and Its Expert System. Shenyang: Liaoning Science and Technology Publishing House (卢佩章, 张玉奎, 梁鑫淼. 高效液相色谱法及其专家系统. 沈阳: 辽宁科学技术出版社), 1992: 307
[21] Li Y Y, Hu C R. Experiment Design and Data Processing. Beijing: Chemical Industry Press (李云雁,胡传荣. 试验设计与数据处理. 北京: 化学工业出版社), 2008: 171
[22] Yu X J, Ding G S, Jin D L, et al. Journal of Zhejiang Sci-Tech University (俞晓晶, 丁高松, 金达莱, 等. 浙江理工大学学报), 2009, 26(2): 219
[23] Du Y P. Modern Instrumental Analysis Method. Shanghai: East China University of Science and Technology Press (杜一平. 现代仪器分析方法. 上海: 华东理工大学出版社), 2008: 45
[24] Liu L M. Southwest University (刘丽敏. 西南大学), 2008
[25] Snyder L R, Kirkland J J, Glajch J L, ed. Zhang Y K, Wang J, Zhang W B, transl. Practical HPLC Method Development. Beijing: Sino-culture Press (森德尔L R, 柯克兰J J, 格莱吉克J L, 著. 张玉奎, 王杰, 张维冰, 译. 实用高效液相色谱法的建立. 北京: 华文出版社), 2001: 383
[26] Zhu P L. Analysis and Testing Technology and Instruments (朱彭龄. 分析测试技术与仪器), 2010, 3(1): 56
[27] Fa Y, Xu X, Lei X L. Chinese Journal of Scientific Instrument (法洋, 许旭, 雷晓玲. 仪器仪表学报), 2005, 26(S1): 181

编辑推荐

Metrics

阅读次数

全文

HTML			PDF

最新录用	在线预览	正式出版	最新录用	在线预览	正式出版
0	0	0	0	0	51

	来源	本网站

	次数	51
	比例	100%

摘要

最新录用	在线预览	正式出版

0	0	45

	来源	本网站

	次数	45
	比例	100%