涂层技术在毛细管电泳手性分离中的应用

doi:10.3724/SP.J.1123.2014.12041

色谱 ›› 2015, Vol. 33 ›› Issue (4): 334-341.DOI: 10.3724/SP.J.1123.2014.12041

涂层技术在毛细管电泳手性分离中的应用

王丙香¹, 柴微波¹, 唐安娜², 丁国生¹

1. 天津大学药物科学与技术学院, 天津 300072;
2. 南开大学化学学院分析科学研究中心, 天津 300071

收稿日期:2014-12-30 修回日期:2015-02-05 出版日期:2015-04-08 发布日期:2015-03-30
通讯作者: 丁国生
基金资助:
国家自然科学基金项目(21005054,21275081).

Application of coating technology in capillary electrophoresis for chiral separation

WANG Bingxiang¹, CHAI Weibo¹, TANG Anna², DING Guosheng¹

1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;
2. Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, China

Received:2014-12-30 Revised:2015-02-05 Online:2015-04-08 Published:2015-03-30

摘要/Abstract

摘要：

手性是自然界的本质属性之一。手性分离分析技术对生命科学、环境科学、生物工程和药物工程等许多学科都具有十分重要的意义。当前,对不同种类手性化合物进行拆分已成为毛细管电泳技术最具特色的研究和应用领域之一。然而,被分析物(或拆分剂)在毛细管内壁的吸附是毛细管电泳手性分离中的常见问题。涂层技术就是采用不同的方法对毛细管内壁进行改性,是抑制非特异性吸附、提高分离效率及分离重现性最简便和最有效的方法。本文主要综述了近十几年来各种涂层技术在毛细管电泳手性分离领域的应用现状,并对毛细管涂层技术今后的发展进行了展望。

关键词: 毛细管电泳, 手性分离, 涂层, 综述

Abstract:

Chirality is one of the intrinsic attributes of the nature. Chiral separation and analysis are of great importance in many research fields, such as life science, environmental science, biological engineering and pharmaceutical engineering. Currently, chiral capillary electrophoresis technique used for the enantioselective resolution of different kinds of racemates has become one of the most distinctive research and application fields. However, the adsorption of the analytes (or chiral selectors) on the inner wall of the capillary is a common problem in capillary electrophoresis chiral separation. Coating technology, namely modification of the inner wall of the capillary, is the simplest and most effective way to suppress disadvantageous adsorption, and to improve the separation efficiency and analysis repeatability. In this review, the recent applications of different coating procedures in chiral analysis are presented, and the future developments in this field are also prospected.

Key words: capillary electrophoresis (CE), chiral separation, coating, review

中图分类号:

O658

王丙香, 柴微波, 唐安娜, 丁国生. 涂层技术在毛细管电泳手性分离中的应用[J]. 色谱, 2015, 33(4): 334-341.

WANG Bingxiang, CHAI Weibo, TANG Anna, DING Guosheng. Application of coating technology in capillary electrophoresis for chiral separation[J]. Chinese Journal of Chromatography, 2015, 33(4): 334-341.

参考文献

[1] Pei L, Lucy C A. J Chromatogr A, 2014, 1365: 226
[2] Cheong W J, Ali F, Kim Y S, et al. J Chromatogr A, 2013, 1308: 1
[3] Rezanka P, Navratilová K, Rezanka M, et al. Electrophoresis, 2014, 35: 2701
[4] Escuder-Gilabert L, Martín-Biosca Y, Medina-Hernández M J, et al. J Chromatogr A, 2014, 1357: 2
[5] Dominguez-Vega E, Perez-Fernández V, Crego A L. Electrophoresis, 2014, 35: 28
[6] Kang J W, Yang Y T, You J M, et al. J Chromatogr A, 1998, 825: 81
[7] Kang J W, Wistuba D, Schurig V. Electrophoresis, 2003, 24: 2674
[8] Sanchez-Hernandez L, Dominguez-Vega E, Montealegre C, et al. Electrophoresis, 2014, 35: 1244
[9] Katayama H, Ishihama Y, Asakawa N. Anal Chem, 1998, 70(11): 2254
[10] Katayama H, Ishihama Y, Asakawa N. Anal Chem, 1998, 70(24): 5272
[11] Nehme R, Perrin R, Guerlavais V. Electrophoresis, 2009, 30: 3772
[12] Zakaria P, Macka M, Haddad P R. J Chromatogr A, 2004, 1031: 179
[13] Han Y H, Bai Y, Xiao Y L, et al. Electrophoresis, 2011, 32: 2693
[14] Hjerten S, Wu B L. J Chromatogr, 1985, 347: 191
[15] Bednar P, Aturki Z, Stransky Z, et al. Electrophoresis, 2001, 22: 2129
[16] Aturki Z, Desiderio C, Mannina L, et al. J Chromatogr A, 1998, 817: 91
[17] Chiari M, Cretich M, Crini G, et al. J Chromatogr A, 2000, 894: 95
[18] Wang Z Y, Wang J F, Hu Z D, et al. Electrophoresis, 2007, 28: 938
[19] Wang Z Y, Mu C J, Kang J W, et al. Chromatographia, 2012, 75: 1211
[20] Magnusson J, Wan H, Blomberg L G. Electrophoresis, 2002, 23: 3013
[21] Awadallah B, Schmidt P C, Holzgrabe U, et al. Electrophoresis, 2003, 24: 2627
[22] Zhao S L, Liu Y M. Anal Chim Acta, 2001, 426: 65
[23] Barker G E, Russo P, Hartwick R A. Anal Chem, 1992, 64(23): 3024
[24] Wu B, Wang Q Q, Liu Q, et al. Electrophoresis, 2005, 26: 1013
[25] Sun X F, Li D, Lee M L. Anal Chem, 2009, 81(15): 6278
[26] Schulze M, Belder D. Electrophoresis, 2012, 33: 370
[27] Vaccher M P, Lipka E, Bonte J P, et al. Electrophoresis, 2005, 26: 2974
[28] Suntornsuk L, Ployngam S. J Pharm Biomed Anal, 2010, 51: 541
[29] Du Y X, Chen J M. Chinese Journal of Analytical Chemistry (杜迎翔, 陈建民. 分析化学), 2004, 32(10): 1295
[30] Ali I, Aboul-Enein H Y. J Sep Sci, 2006, 29: 762
[31] Okamoto Y, Yashima E. Angew Chem Int Ed, 1998, 37: 1020
[32] Rezanka P, Navratiloa K, Rezanka M, et al. Electrophoresis, 2014, 35: 2701
[33] Escuder-Gilabert L, Martin-Biosca Y, Medina-Hernandez M J, et al. J Chromatogr A, 2014, 1357: 2
[34] Xiao Y, Ng S C, Tan T T Y, et al. J Chromatogr A, 2012, 1269: 52
[35] Prokhorova A F, Kuznetsov M A, Shapovalova E N, et al. Procedia Chem, 2010, 2: 9
[36] Lee D, Shamsi S A. Electrophoresis, 2002, 23: 1314
[37] Wang Y C, Zeng Z R, Guan N, et al. Electrophoresis, 2001, 22: 2167
[38] Stavrou I J, Moore L Jr, Fernand V E, et al. Electrophoresis, 2013, 34: 1334
[39] Gotti R, Calleri E, Massolini G, et al. Electrophoresis, 2006, 27: 4746
[40] Geng L, Bo T, Liu H, et al. Chromatographia, 2004, 59: 65
[41] Bo T, Wiedmer S K, Riekkola M L. Electrophoresis, 2004, 25: 1784
[42] Han N Y, Hautala J T, Bo T, et al. Electrophoresis, 2006, 27: 1502
[43] Wiedmer S K, Bo T, Riekkola M L. Anal Biochem, 2008, 373: 26
[44] Zuo X B, Wang K, Zhou L J, et al. Electrophoresis, 2003, 24: 3202
[45] Kamande M W, Zhu X F, Kapnissi-Christodoulou C, et al. Anal Chem, 2004, 76(22): 6681
[46] Dubsky P, Svobodova J, Tesarova E, et al. J Chromatogr B, 2008, 875: 35
[47] Al-Othman Z A, Al-Warthan A, Alam S D, et al. Biomed Chromatogr, 2014, 28: 1514
[48] Dai R J, Tang L, Li H, et al. J Appl Polym Sci, 2007, 106: 2041
[49] Lee H, Dellatore S M, Miller W M. Science, 2007, 318: 426
[50] Ouyang R Z, Lei J P, Ju H X. Chem Commun, 2008: 5761
[51] Kohri M, Nannichi Y, Kohma H, et al. Colloids Surf A, 2014, 449: 114
[52] Liu C M, Liang R P, Wang X N, et al. J Chromatogr A, 2013, 1294: 145
[53] Liang R P, Wang X N, Liu C M, et al. J Chromatogr A, 2014, 1323: 135
[54] Chang C L, Wang X, Bai Y, et al. Trends Anal Chem, 2012, 39: 195
[55] Chen J, Ding G S, Yue C Y, et al. Chinese Journal of Chromatography (陈杰, 丁国生, 岳春月, 等. 色谱), 2012, 30(1): 3
[56] Li S Z, Ding G S. Journal of Instrumental Analysis (李世滋, 丁国生. 分析测试学报), 2014, 33(5): 615
[57] Iacob B C, Bodoki E, Oprean R. Electrophoresis, 2014, 35: 2722
[58] Liang R P, Liu C M, Meng X Y, et al. J Chromatogr A, 2012, 1266: 95
[59] Na N, Hu Y P, Ouyang J, et al. Anal Chim Acta, 2004, 527: 139
[60] Chen J L, Hsieh K H. Electrophoresis, 2011, 32: 398
[61] Li M, Liu X, Jiang F Y, et al. J Chromatogr A, 2011, 1218: 3725
[62] Weng X X, Bi H Y, Liu B H, et al. Electrophoresis, 2006, 27: 3129
[63] Dong X L, Wu R A, Dong J, et al. Electrophoresis, 2008, 29: 3933
[64] Kitagawa F, Sudaki H, Sueyoshi K, et al. Anal Sci, 2013, 29: 107
[65] Wang D M, Song X J, Duan Y, et al. Electrophoresis, 2013, 34: 1339
[66] Yue C Y, Ding G S, Liu F J, et al. J Chromatogr A, 2013, 1311: 176
[67] Li H, Ding G S, Yue C Y, et al. Electrophoresis, 2012, 33: 2012
[68] Liu F J, Ding G S, Tang A N. Food Chem, 2014, 145: 109
[69] Liu F J, Liu C T, Li W, et al. Talanta, 2015, 132: 366
[70] Wang B X, Chai W B, Ding G S, et al. J Sep Sci, 2015, 38: 332
[71] Gong Z S, Duan L P, Tang A N. Microchim Acta, DOI: 10.1007/s00604-015-1449-0
[72] Yang Y, Wu J W, Gou X L, et al. Anal Methods, 2013, 5: 5753
[73] Kitagawa F, Kamiya M, Otsuka K. J Chromatogr B, 2008, 875: 323
[74] Chu Y J, Xu W C, Edgar J S, et al. J Appl Polym Sci, 2011, 122: 2167
[75] Ye N S, Li J, Xie Y L, et al. Electrophoresis, 2013, 34: 841
[76] Li X J, Chang C L, Wang X, et al. Electrophoresis, 2014, 35: 2733
[77] Fei Z X, Zhang M, Zhang J H, et al. Anal Chim Acta, 2014, 830: 49

涂层技术在毛细管电泳手性分离中的应用

Application of coating technology in capillary electrophoresis for chiral separation

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

扫码分享

参考文献

相关文章 15

编辑推荐

Metrics

[1]	周然锋, 张惠贤, 尹小丽, 彭西甜. 新型纳米材料在农产品安全分析中的应用进展[J]. 色谱, 2023, 41(9): 731-741.
[2]	温亚伦, 邵宇辰, 赵新颖, 屈锋. 2022年毛细管电泳技术年度回顾[J]. 色谱, 2023, 41(5): 377-385.
[3]	解伟亚, 朱晓晗, 梅宏成, 郭洪玲, 李亚军, 黄阳, 秦皓, 朱军, 胡灿. 基于功能材料的固相微萃取技术及其在法庭科学领域中的应用[J]. 色谱, 2023, 41(4): 302-311.
[4]	欧阳艺兰, 易琳, 邱露允, 张真庆. 色谱技术在肝素结构分析中的研究进展[J]. 色谱, 2023, 41(2): 107-121.
[5]	张含智, 李凤, 康经武. 毛细管电泳-无鞘流电喷雾质谱用于药物分析[J]. 色谱, 2023, 41(2): 160-167.
[6]	刘华林, 李亚楠, 字敏, 陈政, 段爱红, 袁黎明. 基于共价有机框架材料TpPa-NH₂-Glu的高效液相色谱固定相用于分离手性化合物[J]. 色谱, 2023, 41(2): 187-194.
[7]	江若可, 丁晓静. 非水毛细管电泳法同时测定消毒剂、个人护理品及药膏中三氯生、三氯卡班和对氯间二甲苯酚[J]. 色谱, 2023, 41(2): 168-177.
[8]	翟洪稳, 马红玉, 曹梅荣, 张明星, 马俊美, 张岩, 李强. 在线样品制备技术耦合液相色谱-质谱系统在食品危害物检测中的应用进展[J]. 色谱, 2023, 41(12): 1062-1072.
[9]	余涛, 陈立, 张文敏, 张兰, 卢巧梅. 微孔有机网络材料的合成方法及其在样品前处理中的应用进展[J]. 色谱, 2023, 41(12): 1052-1061.
[10]	王国秀, 陈永雷, 吕文娟, 陈宏丽, 陈兴国. 共价有机框架材料在毛细管电色谱中的应用进展[J]. 色谱, 2023, 41(10): 835-842.
[11]	郑康妮, 秦该照, 蒋雪菲, 章俊辉, 袁黎明. 多孔有机笼的制备及其用作毛细管电色谱手性固定相[J]. 色谱, 2023, 41(10): 929-936.
[12]	闫美婷, 龙文雯, 陶雪平, 王丹, 夏之宁, 付琦峰. 金属有机骨架材料在色谱固定相构建及应用中的研究进展[J]. 色谱, 2023, 41(10): 879-890.
[13]	宋春颖, 金高娃, 俞东萍, 夏东海, 丰静, 郭志谋, 梁鑫淼. 超临界流体色谱固定相的发展及在天然产物中的应用[J]. 色谱, 2023, 41(10): 866-878.
[14]	蒋文倩, 陈宇媚, 毕文韬. 基于低共熔溶剂的多孔有机框架材料合成及其在固相萃取中的应用[J]. 色谱, 2023, 41(10): 901-910.
[15]	杨涵, 汤雯淇, 曾楚, 孟莎莎, 徐铭. 高效金属有机骨架气相色谱固定相的理性设计[J]. 色谱, 2023, 41(10): 853-865.