混合色谱填料的研究进展

doi:10.3724/SP.J.1123.2015.06025

色谱 ›› 2015, Vol. 33 ›› Issue (11): 1140-1146.DOI: 10.3724/SP.J.1123.2015.06025

• 特殊选择性分离介质的制备专栏 • 上一篇下一篇

混合色谱填料的研究进展

徐基伟¹, 孙元社², 唐涛^1,2, 夏明珠¹, 雷武¹, 王风云¹, 李彤²

1. 南京理工大学, 江苏南京 210094;
2. 大连依利特分析仪器有限公司, 辽宁大连 116023

收稿日期:2015-06-17 出版日期:2015-11-08 发布日期:2012-05-30
通讯作者: 李彤
基金资助:
国家自然科学基金面上项目(51472121);国家重大科学仪器设备开发专项(2012YQ12004401,2012YQ12004403);江苏省高等学校优势学科建设工程项目.

State of art of mixed-mode stationary phase

XU Jiwei¹, SUN Yuanshe², TANG Tao^1,2, XIA Mingzhu¹, LEI Wu¹, WANG Fengyun¹, LI Tong²

1. Nanjing University of Science and Technology, Nanjing 210094, China;
2. Dalian Elite Analytical Instruments Co., Ltd., Dalian 116023, China

Received:2015-06-17 Online:2015-11-08 Published:2012-05-30

摘要/Abstract

摘要：

随着科学技术的发展,人们需要分离分析的样品越来越复杂,尤其是多肽、蛋白质类生物样品的复杂性使得单一模式色谱难以满足分离分析的要求。混合模式色谱因其独特的分离性能,可以在一次分离中获得与多维色谱相当的分离效果,而且可以避免多维色谱系统结构复杂、流动相兼容性差、分析时间长等问题,成为近年来的研究热点之一。混合模式色谱的研究重点是色谱固定相的设计与开发。混合模式色谱固定相包括反相/离子交换混合固定相、反相/亲水混合固定相、亲水/离子交换混合固定相、两性离子交换混合固定相及三相混合固定相。本文综述了近年来混合模式色谱填料的研究及应用进展,并对混合模式色谱及固定相的发展前景进行了展望。

关键词: 反相/离子交换混合固定相, 反相/亲水混合固定相, 混合色谱, 两性离子交换混合固定相, 亲水/离子交换混合固定相

Abstract:

With the development of science and technology, more and more complex samples like peptides and proteins need to be separated. It is difficult to separate them by single mode chromatography. Due to the unique separation character of mixed-mode chromatography, the same separation performance can be obtained in mixed-mode chromatography in one separation as multidimensional chromatography. And some disadvantages of multidimensional chromatography can be avoided in mixed-mode chromatography, such as the complexity of the system, the poor compatibility of mobile phases and the long analytical time. More and more attention is devoted to the mixed-mode chromatography in recent years. The focus on the mixed-mode chromatography is to design new structures of mixed-mode stationary phase. At present, mixed-mode stationary phases included reversed-phase/ion-exchange, reversed-phase/hydrophilic, hydrophilic/ion-exchange, zwitterionic and trimode mixed-mode stationary phases. The kinds of mixed-mode stationary phases are summarized and their features and applications in different fields are discussed in this review.

Key words: hydrophilic/ion-exchange mixed-mode stationary phase, mixed-mode chromatography, reversed-phase/hydrophilic mixed-mode stationary phase, reversed-phase/ion-exchange mixed-mode stationary phase, zwitterion exchange mixed-mode stationary phase

中图分类号:

O658

徐基伟, 孙元社, 唐涛, 夏明珠, 雷武, 王风云, 李彤. 混合色谱填料的研究进展[J]. 色谱, 2015, 33(11): 1140-1146.

XU Jiwei, SUN Yuanshe, TANG Tao, XIA Mingzhu, LEI Wu, WANG Fengyun, LI Tong. State of art of mixed-mode stationary phase[J]. Chinese Journal of Chromatography, 2015, 33(11): 1140-1146.

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混合色谱填料的研究进展

State of art of mixed-mode stationary phase

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