色谱固定相的超支化和聚酰胺-胺树状大分子接枝修饰方法研究进展

doi:10.3724/SP.J.1123.2018.04010

色谱 ›› 2018, Vol. 36 ›› Issue (9): 835-841.DOI: 10.3724/SP.J.1123.2018.04010

色谱固定相的超支化和聚酰胺-胺树状大分子接枝修饰方法研究进展

郭丹丹¹, 朱越锋², 朱岩¹

1. 浙江大学西溪校区化学系, 浙江杭州 310028;
2. 浙江大学医学院附属邵逸夫医院普外科, 浙江杭州 310016

收稿日期:2018-04-07 出版日期:2018-09-08 发布日期:2014-08-05
通讯作者: 朱岩,E-mail:zhuyan@zju.edu.cn
基金资助:
国家自然科学基金（21405141，81603252）；浙江省自然科学基金（LZ16B050001，LY15B050001，LY15B010005，LQ17H280002，Y16H020015）；浙江省微量有毒化学品健康风险评价重点实验室项目（2014006，2014007）.

Advances in the hyperbranched and poly amidoamine dendrimers grafting modification methods of chromatographic stationary phase

GUO Dandan¹, ZHU Yuefeng², ZHU Yan¹

1. Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, China;
2. General Surgery Department Sir Run Run Shaw Hospital, School of Medicine Zhejiang University, Hangzhou 310016, China

Received:2018-04-07 Online:2018-09-08 Published:2014-08-05
Supported by:
National Natural Science Foundation of China (Nos. 21405141, 81603252); Zhejiang Provincial Natural Science Foundation of China (Nos. LZ16B050001, LY15B050001, LY15B010005, LQ17H280002, Y16H020015); Project of Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang Province (Nos. 2014006, 2014007).

摘要/Abstract

摘要：

随着色谱固定相制备技术深入发展，固定相填料的修饰方法日渐成熟，主要包括固定相表面直接化学反应、表面附聚、共价接枝和超支化修饰。其中，以缩聚反应为主的超支化修饰方法自提出以来备受研究者的青睐，已经被应用于多种阴离子交换色谱固定相填料的制备。近些年来，和超支化聚合物具有相似结构的树状大分子由于其独特的物理性能、完美的树状结构和大量活性官能团，也逐渐被应用于各种色谱固定相填料的修饰，并有望进一步完善固定相填料的结构和分离性能。该文主要总结了超支化修饰方法和以聚酰胺-胺为主的树状大分子接枝修饰方法在色谱固定相填料制备中的应用，并对其未来发展进行展望。

关键词: 超支化, 聚酰胺-胺, 色谱固定相, 综述

Abstract:

With the rapid development of chromatographic stationary-phase preparation technology, various modified methods are becoming increasingly mature, mainly including direct surface chemical reactions, agglomeration, grafting, and hyperbranched modification. Among these methods, hyperbranched modification based on polycondensation has been popular with researchers since it was proposed, and it has been applied to the preparation of various anion exchangers. Dendrimers are a class of three-dimensional, highly ordered dendritic macromolecules with perfect structure, high degree of surface functionality, and unique physicochemical properties. Recently, they have also gradually been applied in various chromatographic stationary-phase modifications and are expected to improve the structure and separation performance of the stationary phase, because its structure is similar to those of hyperbranched polymers. This article mainly summarizes the applications of hyperbranched and poly amidoamine dendrimers using grafted modification methods in the preparation of the chromatographic stationary phase. Finally, the trends and promising prospects of this field are presented.

Key words: chromatographic stationary phase, hyperbranched, poly amidoamine (PAMAM), review

中图分类号:

O658

郭丹丹, 朱越锋, 朱岩. 色谱固定相的超支化和聚酰胺-胺树状大分子接枝修饰方法研究进展[J]. 色谱, 2018, 36(9): 835-841.

GUO Dandan, ZHU Yuefeng, ZHU Yan. Advances in the hyperbranched and poly amidoamine dendrimers grafting modification methods of chromatographic stationary phase[J]. Chinese Journal of Chromatography, 2018, 36(9): 835-841.

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色谱固定相的超支化和聚酰胺-胺树状大分子接枝修饰方法研究进展

Advances in the hyperbranched and poly amidoamine dendrimers grafting modification methods of chromatographic stationary phase

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