多柱色谱技术进展

doi:10.3724/SP.J.1123.2018.11023

摘要/Abstract

摘要：

在色谱分析过程中，利用串联、并联或串并联结合的方式将多根色谱柱组合起来，可以实现高通量和高分辨的分离效果。相比于传统单柱色谱技术，多柱技术很好地满足了批量样品分析和复杂生物样品分离分析的需求，因此引起了广泛关注。该文对多柱技术在多维分离、芯片色谱、毛细管电泳、固定相筛选以及串联色谱等领域的应用进行了综述，并对其发展前景进行了展望。

关键词: 串/并联色谱柱, 多维色谱, 多柱色谱, 高通量, 芯片色谱, 综述

Abstract:

Multi-column chromatographic technologies provide high throughput and high resolution separations through parallel, serial or parallel-serial column combinations. In comparison with classical single-column based chromatography, multi-column chromatography well satisfied the need for separations of large batch samples and highly complex bio-samples, and therefore attracted extensive interests. In this review, we discussed the recent developments in multi-column chromatography and its applications in multidimensional separation, chip chromatography, capillary electrophoresis, stationary-phase screening, and serial column chromatography. We also discussed the limitations and future developments in multi-column chromatography.

Key words: chip separation, high-throughput, multi-column chromatography, multidimensional chromatography, parallel/serial columns, review

中图分类号:

O658

王晓飞, 孙楷越, 张博. 多柱色谱技术进展[J]. 色谱, 2019, 37(2): 123-131.

WANG Xiaofei, SUN Kaiyue, ZHANG Bo. Multi-column technologies in chromatographic analysis[J]. Chinese Journal of Chromatography, 2019, 37(2): 123-131.

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