微流控芯片技术在生殖研究中的进展

doi:10.3724/SP.J.1123.2019.01036

色谱 ›› 2019, Vol. 37 ›› Issue (9): 925-931.DOI: 10.3724/SP.J.1123.2019.01036

微流控芯片技术在生殖研究中的进展

石杨, 邵小光

大连市妇女儿童医疗中心, 生殖与遗传研究医学中心, 辽宁大连 116037

收稿日期:2019-01-22 出版日期:2019-09-08 发布日期:2015-07-30
通讯作者: 邵小光
基金资助:
国家自然科学基金（81603075）.

Development of microfluidic technology in reproductive researches

SHI Yang, SHAO Xiaoguang

Medical Center for Reproductive and Genetic Research, Dalian Municipal Women and Children's Medical Center, Dalian 116037, China

Received:2019-01-22 Online:2019-09-08 Published:2015-07-30
Supported by:
National Natural Science Foundation of China (No. 81603075).

摘要/Abstract

摘要： 生殖是生物体最基本特征之一，是物种得以延续和进化的保证。近年来，微流控芯片系统得到了迅猛发展，技术也逐渐成熟，具有良好的应用前景。在生殖研究中，微流控技术具有以下优势：微管道的形状和尺寸可以灵活设计，从而更好地模拟生理环境；微流控芯片对样品的消耗量低；微流控技术具有很高的集成性。微流控技术已被应用到精子活力评价与筛选、精子的化学趋向性筛选、卵丘细胞去除、透明带移除、卵细胞定位与筛选、受精过程、早期胚胎培养以及生殖器官模拟等各个方面。该文着重介绍近几年基于微流控技术生殖研究的最新进展，并对其应用前景进行展望。

关键词: 生殖, 生殖微环境, 微流控芯片, 综述

Abstract: Reproduction is one of the most basic characteristics of organisms, and the guarantee of the continuation and evolution of a species. As the country with world's largest population, China has been gradually increasing its investment in research on the reproductive system in recent years, particularly in the field of basic research. The rapid development and wide application of the microfluidic technology since its birth are sufficient to explain its application prospect. Currently, infertility and birth defects are major problems in the field of reproduction. Micro-reproductive technologies, including microfluidic and organs-on-chips, are formed through the combination of a wide range of basic science and bioengineering technologies. In reproductive research, microfluidic technology display several advantages:flexible design of the microchannel shape and size to better simulate the physiological environment, the low consumption of microfluidic chip, and highly integrated microfluidic technology. Microfluidic technology has been applied to various processes including sperm vitality evaluation and screening, sperm chemotaxis, cumulus oophorus cell removal, zona pellucida removal, ootid localization and screening, fertilization, early embryo culture and reproductive organ simulation. This paper introduces the recent progress in reproductive research based on microfluidic technology and its application prospects.

Key words: microfluidic, reproductive, reproductive microenvironment, review

中图分类号:

O658

石杨, 邵小光. 微流控芯片技术在生殖研究中的进展[J]. 色谱, 2019, 37(9): 925-931.

SHI Yang, SHAO Xiaoguang. Development of microfluidic technology in reproductive researches[J]. Chinese Journal of Chromatography, 2019, 37(9): 925-931.

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微流控芯片技术在生殖研究中的进展

Development of microfluidic technology in reproductive researches

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