树状大分子接枝型聚合物色谱分离材料研究进展

doi:10.3724/SP.J.1123.2019.07022

色谱 ›› 2020, Vol. 38 ›› Issue (4): 366-371.DOI: 10.3724/SP.J.1123.2019.07022

树状大分子接枝型聚合物色谱分离材料研究进展

支明玉¹^,², 何艺², 郭丹丹¹^,³^,^*(), 朱岩¹^,^*()

1. 浙江大学西溪校区化学系,浙江杭州 310028
2. 杭州职业技术学院,浙江杭州 310018
3. 宁波大学新药技术研究院,浙江宁波 315211

收稿日期:2019-08-06 出版日期:2020-04-08 发布日期:2020-12-10
通讯作者: 郭丹丹,朱岩
基金资助:
国家自然科学基金(21974121);浙江省自然科学基金(LY18C200001);浙江省自然科学基金(YB19B050002);浙江省自然科学基金(Z16B050001)

Advances in polymer-based dendrimer-grafted chromatographic separation materials

ZHI Mingyu¹^,², HE Yi², GUO Dandan¹^,³^,^*(), ZHU Yan¹^,^*()

1. Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, China
2. Hangzhou Vocational and Technical College, Hangzhou 310018, China
3. Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China

Received:2019-08-06 Online:2020-04-08 Published:2020-12-10
Contact: GUO Dandan, ZHU Yan
Supported by:
National Natural Science Foundation of China(21974121);Zhejiang Provincial Natural Science Foundation of China(LY18C200001);Zhejiang Provincial Natural Science Foundation of China(YB19B050002);Zhejiang Provincial Natural Science Foundation of China(Z16B050001)

摘要/Abstract

摘要：

随着色谱固定相制备技术和材料科学领域的不断发展,目前已经有大量修饰方法和新型材料被用于固相萃取、高效液相色谱以及离子色谱聚合物固定相填料的功能化修饰。其中聚酰胺-胺(PAMAM)树状大分子由于其独特的结构和性质,在色谱分离材料结构完善和性能提升中也发挥了重要的作用。该文主要综述了PAMAM树状大分子在以聚合物为基质的色谱分离材料修饰中的应用,并对其今后的发展进行了展望。

关键词: 树状大分子, 聚合物基质, 吸附剂, 液相色谱, 离子色谱

Abstract:

With the continuous developments in stationary phase preparation technology and materials science, numerous modification methods and new materials have been employed for the functional modification of the polymer stationary phases in solid-phase extraction, high performance liquid chromatography and ion chromatography. In particular, because of their unique structure and properties, poly(amidoamine) (PAMAM) dendrimers play an important role in improving the structure and performance of chromatographic separation materials. In this paper, the application of PAMAM to the modification of polymer-based chromatographic separation materials is reviewed, and further developments are prospected.

Key words: dendrimers, polymer matrix, adsorbent, liquid chromatography, ion chromatography

中图分类号:

O658

支明玉, 何艺, 郭丹丹, 朱岩. 树状大分子接枝型聚合物色谱分离材料研究进展[J]. 色谱, 2020, 38(4): 366-371.

ZHI Mingyu, HE Yi, GUO Dandan, ZHU Yan. Advances in polymer-based dendrimer-grafted chromatographic separation materials[J]. Chinese Journal of Chromatography, 2020, 38(4): 366-371.

图/表 6

图1 聚酰胺-胺树状大分子的合成[26]

Fig. 1 Synthesis of poly amidoamine (PAMAM)[26]

表1 PAMAM接枝型聚合物色谱分离材料

Table 1 PAMAM grafting chromatographic separation materials

Materials	Matrix	Analyte	Mechanism	Samples	Ref.
Adsorbents	PS-GMA	glyphosate	electrostatic adsorption	drinking water	[29]
HPLC stationary phase	PS-GMA	aniline	π-π interation electrostatic repulsion	hair dye	[30]
Anion exchangers	PS-GMA	anions	ion exchange	traditional Chinese medicine	[26]
Anion exchangers	PS-GMA@GO	anions	ion exchange	organic acids	[31]

图2 (a)草甘膦分子去质子化反应和(b)草甘膦吸附[29]

Fig. 2 (a) Deprotonation reactions of glyphosate and (b) glyphosate adsorption[29]

图3 聚合物基质的高效液相色谱固定相填料的修饰和苯胺类物质的分离[30]

Fig. 3 Modification of polymer stationary phase for HPLC and separation of aniline compounds[30]

图4 聚合物基质阴离子色谱固定相填料的制备[26]

Fig. 4 Synthesis process of polymer based anion stationary phase[26] BDDE: 1,4-butanediol diglycidyl ether.

图5 聚酰胺-胺接枝型氧化石墨烯杂化聚合物离子色谱固定相填料[31]

Fig. 5 PAMAM-grafted graphene oxide polymer composite stationary phase for ion chromatography[26] Peaks: 1. F-; 2. Cl-; 3. N O 2 -; 4. Br-; 5. N O 3 -; 6. S O 4 2 -.

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树状大分子接枝型聚合物色谱分离材料研究进展

Advances in polymer-based dendrimer-grafted chromatographic separation materials

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