分散液液微萃取技术及其在生物样品分析中的研究进展

doi:10.3724/SP.J.1123.2019.10026

摘要/Abstract

摘要：

分散液液微萃取是一种新型微萃取技术，具有易操作、低成本、耗时短、环境友好、萃取效率高等优点。该文着眼于分散液液微萃取技术中萃取剂的性质及辅助分散方式，综述了常规分散液液微萃取、离子液体分散液液微萃取、超声辅助分散液液微萃取等多种萃取模式，并重点归纳总结了近5年分散液液微萃取技术在生物样品分析领域的应用进展。

关键词: 分散液液微萃取, 萃取剂, 分散方式, 生物样品, 综述

Abstract:

Dispersive liquid-liquid microextraction (DLLME) is a mini-extraction technology with merits of low cost, environment friendliness, and high extraction efficiency; moreover, this method is easy to operate and requires only a short operation time. In this paper, several extraction models, including normal dispersive liquid-liquid microextraction, ionic liquid dispersive liquid-liquid microextraction, and ultrasound-assisted dispersive liquid-liquid microextraction, are reviewed according to the type of extraction solvents and dispersive methods. This paper also summarizes the application of DLLME to the analysis of biological samples in the last five years.

Key words: dispersive liquid-liquid microextraction (DLLME), extraction solvents, dispersive methods, biological samples, review

施艺玮, 张宁, 操雯, 洪战英. 分散液液微萃取技术及其在生物样品分析中的研究进展[J]. 色谱, 2020, 38(5): 491-501.

SHI Yiwei, ZHANG Ning, CAO Wen, HONG Zhanying. Advances in dispersive liquid-liquid microextraction and its application to analysis of biological samples[J]. Chinese Journal of Chromatography, 2020, 38(5): 491-501.

图/表 4

图1 分散液液微萃取的分类及其在生物样品中的应用

Fig. 1 Classification of DLLME and application to biological samples n-DLLME: normal dispersive liquid-liquid microextraction; IL-DLLME: ionic liquid dispersive liquid-liquid microextraction; DLLME-SFOD: dispersive liquid-liquid microextraction based on solidification of floating organic droplet; LDS-DLLME: low density solvent dispersive liquid-liquid microextraction; UA-DLLME: ultrasound-assisted dispersive liquid-liquid microextraction; VA-DLLME: vortex-assisted dispersive liquid-liquid microextraction; AA-DLLME: air-assisted dispersive liquid-liquid microextraction.

图2 (a) n-DLLME、(b)DLLME-SFOD和(c)AA-DLLME萃取过程示意图

Fig. 2 Diagrams of the extraction processes of (a) n-DLLME, (b) DLLME-SFOD and (c) AA-DLLME

图3 AA-DLLME-SFOD-AALLME-SFOD的萃取过程

Fig. 3 Extraction procedure of AA-DLLME-SFOD-AALLME-SFOD

表1 分散液液微萃取在生物样品中的应用

Table 1 Applications of DLLME to biological samples

参考文献

1	Rezaee M , Assadi Y , Milani Hosseini M R , et al. J Chromatogr A, 2006, 1116 (1/2): 1
2	Mansour F R , Khairy M A . J Chromatogr B Analyt Technol Biomed Life Sci, 2017, 1061/1062: 382
3	Liu Y H , Chen P S , Huang S D . J AOAC Int, 2017, 100 (1): 212
4	Zhang J P , Jiang X D , Huang W , et al. Chinese Journal of Chromatography, 2018, 36 (5): 458
4	张吉苹, 蒋新娣, 黄薇, et al. 色谱, 2018, 36 (5): 458
5	Yan M M , Chen M , Meng X S , et al. Chinese Journal of Chromatography, 2018, 36 (8): 738
5	闫萌萌, 陈萌, 孟宪双, et al. 色谱, 2018, 36 (8): 738
6	Zhang M Y , Hong Z Y , Fan G R . Chinese Journal of New Drugs, 2011, 20 (5): 429
6	张明勇, 洪战英, 范国荣. 中国新药杂志, 2011, 20 (5): 429
7	Alcantara G K , Calixto L A , de Moraes L A , et al. J Anal Methods Chem, 2016, 2016: 1
8	Chen P S , Cheng Y H , Lin S Y , et al. Anal Bioanal Chem, 2016, 408 (2): 629
9	Gupta M K , Jain R , Singh P , et al. J Anal Toxicol, 2015, 39 (5): 365
10	Gong A , Zhu X . Spectrochim Acta A Mol Biomol Spectrosc, 2016, 159: 163
11	Arain S A , Kazi T G , Afridi H I , et al. Ecotoxicol Environ Saf, 2016, 126: 186
12	Maria K , Victoria S . Molecules, 2018, 23 (6): 1437
13	Mollahosseini A , Kamankesh M , Mohammadi A . J Chromatogr Sci, 2019, 57 (6): 575
14	Barfi B , Asghari A , Rajabi M , et al. J Pharm Biomed Anal, 2015, 111: 297
15	Leong M I , Fuh M R , Huang S D . J Chromatogr A, 2014, 1335: 2
16	Shirinnejad M , Sarrafi A H M . J Fluoresc, 2019, 29 (4): 1039
17	Iqbal M , Ezzeldin E , Khalil N Y , et al. J Pharm Biomed Anal, 2019, 164: 1
18	Wu C Q , Li Y , Chang S P , et al. Chinese Journal of Chromatography, 2018, 36 (5): 452
18	吴翠琴, 李颖, 常淑萍, et al. 色谱, 2018, 36 (5): 452
19	Ferrone V , Cotellese R , Carlucci M , et al. J Pharm Biomed Anal, 2018, 151: 266
20	Fernández P , Taboada V , Regenjo M , et al. J Pharm Biomed Anal, 2016, 124: 189
21	Malaei R , Ramezani A M , Absalan G . J Chromatogr B Analyt Technol Biomed Life Sci, 2018, 1089: 60
22	Shu M W , Leong M I , Fuh M R , et al. Analyst, 2012, 137 (9): 2143
23	Meng L , Zhu B , Zheng K , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2017, 1053: 9
24	Zhang K , Li S , Liu C , et al. J Sep Sci, 2019, 42 (2): 574
25	Akramipour R , Golpayegani M R , Gheini S , et al. Talanta, 2018, 86: 17
26	Rocha B A , de Oliveira A R M , Barbosa F Jr . Talanta, 2018, 183: 94
27	Rahmani M , Ghasemi E , Sasani M . Talanta, 2017, 165: 27
28	Lamei N , Ezoddin M , Abdi K . Talanta, 2017, 165: 176
29	Zhang K , Li S , Wang Y , et al. J Chromatogr A, 2020, 460876
30	Mohebbi A , Yaripour S , Farajzadeh M A , et al. J Chromatogr A, 2018, 1571: 84
31	Taheri S , Jalali F , Fattahi N , et al. J Sep Sci, 2015, 38 (2): 309
32	Mashayekhi H A , Khalilian F . J Chromatogr Sci, 2016, 54 (6): 1068
33	Zacharis C K , Tzanavaras P D . J Sep Sci, 2020, 43 (3): 631
34	Farahmand F , Ghasemzadeh B , Naseri A . Spectrochim Acta A Mol Biomol Spectrosc, 2018, 188: 72
35	Abujaber F , Corps Ricardo A I , Rios A , et al. J Pharm Biomed Anal, 2019, 165: 141
36	de Oliveira M L , Rocha B A , Souza V C O , et al. Talanta, 2019, 196: 271
37	Shen X , Liang J , Zheng L , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2018, 1096: 48
38	He Y , Zhao X E , Zhu S , et al. J Chromatogr A, 2016, 1458: 70
39	Vincenti F , Montesano C , Cellucci L . J Chromatogr A, 2019, 1065: 1
40	Talpur S , Kazi T G , Afridi H I , et al. J AOAC Int, 2018, 101 (3): 883
41	Rocha B A , da Costa B R , de Albuquerque N C . Talanta, 2016, 154: 511
42	Pastor-Belda M , Bastida D , Campillo N , et al. J Pharm Biomed Anal, 2016, 129: 458
43	Pastor-Belda M , Fernández-García A J , Campillo N , et al. J Chromatogr A, 2017, 1509: 43
44	Escrivá L , Manyes L , Font G , et al. Toxins (Basel), 2017, 9 (10): 330
45	Mercieca G , Odoardi S , Cassar M , et al. J Pharm Biomed Anal, 2018, 149: 494
46	Campillo N , Marín J , Fenoll J , et al. Talanta, 2017, 174: 638
47	Miekus N , Oledzka I , Plenis A , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2016, 1036/1037: 114
48	Li Y , Zhang W , Wang R G , et al. PLoS One, 2015, 10 (9): e0137194
49	Chen C H , Chao Y Y , Lin Y H , et al. J Chromatogr A, 2018, 1547: 14
50	Odoardi S , Fisichella M , Romolo F S , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 1000: 57
51	Konieczna L , Roszkowska A , Stachowicz-Stencel T , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2018, 1074/1075: 99
52	Jiménez-Díaz I , Iribarne-Durán L M , Ocón O , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2016, 1035: 57
53	Tabani H , Shokri A , Tizro S , et al. Talanta, 2019, 199: 329
54	De Boeck M , Dehaen W , Tytgat J , et al. J Forensic Sci, 2018, 63 (6): 1875
55	Meng L , Zhang W , Meng P , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 989: 46
56	Sena L C , Matos H R , Dórea H S , et al. Toxicology, 2017, 376: 102
57	Pebdani A A , Shabani A M , Dadfarnia S , et al. J Sep Sci, 2016, 39 (10): 1935
58	Ahmadi-Jouibari T , Fattahi N , Shamsipur M , et al. J Pharm Biomed Anal, 2014, 94: 145
59	Wang Y , Zou X L , Zhang W T , et al. Chinese Journal of Analytical Chemistry, 2013, 41 (5): 749
59	王宇, 邹晓莉, 张文滔, et al. 分析化学, 2013, 41 (5): 749
60	Du X H , Xin X Y , Wang J P , et al. Journal of Hebei University (Natural Science Edition), 2018, 38 (6): 596
60	杜雪红, 辛晓莹, 王计彭, et al. 河北大学学报:自然科学版, 2018, 38 (6): 596
61	Zhao L , Zhao P , Wang L , et al. Biomed Chromatogr, 2014, 28 (6): 895
62	Li P , Cui J T , Guo X X , et al. Journal of Instrumental Analysis, 2018, 37 (3): 282
62	李佩, 崔君涛, 郭溪香, et al. 分析测试学报, 2018, 37 (3): 282
63	Ahmadi-Jouibari T , Fattahi N , Shamsipur M , et al. J Pharm Biomed Anal, 2013, 85: 14
64	Yuan Y , Wang Y , Yang M , et al. J Sep Sci, 2018, 41 (10): 2261
65	Cinelli G , Cuomo F , Ambrosone L , et al. Biotechnol Prog, 2019, 35 (3): e2780
66	Li Y , Hu J , Liu W , et al. Talanta, 2019, 195: 785

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