色谱 ›› 2024, Vol. 42 ›› Issue (1): 38-51.DOI: 10.3724/SP.J.1123.2023.04012
胡贝, 李丽霞, 丁晓萍, 刘红, 黄伟, 吕稳(), 李晓健
收稿日期:
2023-04-12
出版日期:
2024-01-08
发布日期:
2024-01-10
通讯作者:
*Tel:(027)87705269,E-mail:lvwenhbyjy@163.com.
基金资助:
HU Bei, LI Lixia, DING Xiaoping, LIU Hong, HUANG Wei, LÜ Wen(), LI Xiaojian
Received:
2023-04-12
Online:
2024-01-08
Published:
2024-01-10
Supported by:
摘要:
建立了超高效液相色谱-串联质谱测定化妆品中87种禁用原料的方法,其适用于水基类、乳液膏霜类和油基类3种常见化妆品基质。实验对提取溶剂、提取时间及色谱、质谱条件进行了考察。水基类和乳液膏霜类化妆品用乙腈分散、50%乙腈水溶液超声提取,油基类化妆品用正己烷分散、70%乙腈水溶液涡旋提取;采用CORTECS C18色谱柱(150 mm×2.1 mm, 2.7 μm)进行分离,以乙腈和0.1%甲酸水溶液为流动相进行梯度洗脱,流速为0.3 mL/min,柱温为40 ℃,进样量为2 μL。采用电喷雾电离(ESI)源,在多反应监测(MRM)模式下采集数据,利用基质匹配标准曲线进行定量分析。结果表明,87种禁用原料在各自的线性范围内具有良好的线性关系,相关系数(r)>0.99,检出限(LOD)为0.07~0.38 μg/g,定量限(LOQ)为0.21~1.15 μg/g。3种化妆品基质中87种禁用原料在低、中、高3个加标水平下的加标回收率为81.7%~115.4%,相对标准偏差(RSD, n=6)为0.4%~9.9%。采用该方法对349批化妆品样品进行测定,共发现8批阳性样品,检出成分分别为甲氧苄啶、特比萘芬、萘甲唑啉、7-甲氧基香豆素和7-甲基香豆素。本方法前处理过程简便,定性、定量可靠,可用于测定化妆品中87种禁用原料,能够为化妆品的快速风险筛查和国家标准的制修订提供技术支撑。
中图分类号:
胡贝, 李丽霞, 丁晓萍, 刘红, 黄伟, 吕稳, 李晓健. 超高效液相色谱-串联质谱法快速测定化妆品中87种禁用原料[J]. 色谱, 2024, 42(1): 38-51.
HU Bei, LI Lixia, DING Xiaoping, LIU Hong, HUANG Wei, LÜ Wen, LI Xiaojian. Rapid determination of 87 prohibited ingredients in cosmetics by ultra performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2024, 42(1): 38-51.
No. | Compound | CAS No. | Retention time/min | Parent ion (m/z) | Daughter ions (m/z) | CV/ V | CEs/ eV | ESI mode |
---|---|---|---|---|---|---|---|---|
1 | ranitidine (雷尼替丁) | 66357-59-3 | 2.67 | 315.2 | 176.1*, 130.1 | 45 | 25, 45 | + |
2 | sulfacetamide (磺胺醋酰) | 144-80-9 | 3.02 | 215.1 | 156.0*, 92.1 | 30 | 15, 30 | + |
3 | dimetridazole (二甲硝咪唑) | 551-92-8 | 3.48 | 142.0 | 96.0*, 81.0 | 45 | 20, 30 | + |
4 | ronidazole (洛硝达唑) | 7681-76-7 | 3.68 | 201.1 | 140.1*, 55.1 | 25 | 15, 30 | + |
5 | sulfadiazine (磺胺嘧啶) | 68-35-9 | 3.93 | 251.1 | 92.1*, 156.1 | 40 | 35, 25 | + |
6 | emedastine (依美斯汀) | 87233-62-3 | 4.76 | 303.3 | 246.2*, 174.2 | 60 | 30, 40 | + |
7 | doxylamine (多西拉敏) | 469-21-6 | 5.48 | 271.2 | 182.2*, 167.2 | 30 | 20, 40 | + |
8 | trimethoprim (甲氧苄啶) | 738-70-5 | 5.58 | 291.2 | 123.1*, 230.2 | 60 | 30, 30 | + |
9 | marbofloxacin (麻保沙星) | 115550-35-1 | 5.61 | 363.1 | 72.1*, 320.2 | 50 | 35, 25 | + |
10 | tinidazole (替硝唑) | 19387-91-8 | 5.63 | 248.1 | 121.0*, 128.0 | 45 | 20, 30 | + |
11 | lomefloxacin (洛美沙星) | 98079-52-8 | 5.99 | 352.2 | 265.2*, 308.2 | 50 | 35, 25 | + |
12 | danofloxacin (达氟沙星) | 112398-08-0 | 6.00 | 358.2 | 340.2*, 96.1 | 55 | 35, 40 | + |
13 | methoxyphenamine (甲氧那明) | 5588-10-3 | 6.01 | 180.2 | 121.1*, 149.1 | 35 | 25, 15 | + |
14 | sulfamethazine (磺胺二甲嘧啶) | 57-68-1 | 6.09 | 279.1 | 186.1*, 156.0 | 40 | 25, 25 | + |
15 | orbifloxacin (奥比沙星) | 113617-63-3 | 6.24 | 396.1 | 352.2*, 295.2 | 50 | 25, 35 | + |
16 | naphazoline (萘甲唑啉) | 550-99-2 | 6.27 | 211.3 | 141.1*, 115.1 | 35 | 28, 37 | + |
17 | ornidazole (奥硝唑) | 16773-42-5 | 6.28 | 220.1 | 128.1*, 82.1 | 45 | 20, 40 | + |
18 | gatifloxacin (加替沙星) | 112811-59-3 | 6.41 | 376.2 | 261.2*, 332.2 | 50 | 40, 25 | + |
19 | sparfloxacin (司帕沙星) | 110871-86-8 | 6.70 | 393.2 | 349.2*, 292.2 | 60 | 30, 40 | + |
20 | methapyrilene (美沙吡林) | 135-23-9 | 6.88 | 262.2 | 97.1*, 217.1 | 35 | 35, 20 | + |
21 | cinoxacin (西诺沙星) | 28657-80-9 | 7.61 | 263.1 | 245.1*, 189.1 | 40 | 20, 40 | + |
22 | triprolidine (曲普利啶) | 6138-79-0 | 8.13 | 279.2 | 208.2*, 193.2 | 30 | 20, 45 | + |
23 | bromisoval (溴米索伐) | 496-67-3 | 8.27 | 223.5 | 179.9*, 57.1 | 30 | 10, 18 | + |
24 | xanthotol (8-羟基补骨脂素) | 2009-24-7 | 8.33 | 203.1 | 147.1*, 131.1 | 50 | 30, 30 | + |
25 | ketotifen (酮替芬) | 34580-14-8 | 8.34 | 310.1 | 96.1*, 97.1 | 60 | 40, 50 | + |
26 | phenacetin (非那西丁) | 62-44-2 | 8.38 | 180.1 | 110.2*, 138.1 | 30 | 18, 15 | + |
27 | oxolinic (恶喹酸) | 14698-29-4 | 8.51 | 262.1 | 244.1*, 216.1 | 30 | 25, 40 | + |
28 | mizolastine (咪唑斯汀) | 108612-45-9 | 8.78 | 433.3 | 109.1*, 308.3 | 50 | 55, 35 | + |
29 | olopatadine (奥洛他定) | 140462-76-6 | 9.77 | 338.3 | 247.2*, 165.1 | 50 | 30, 35 | + |
30 | decloxizine (去氯羟嗪) | 13073-96-6 | 10.09 | 341.2 | 167.1*, 152.2 | 40 | 25, 60 | + |
31 | chlomezanone (氯美扎酮) | 80-77-3 | 10.24 | 274.2 | 154.2*, 209.2 | 30 | 15, 12 | + |
32 | 7-methoxycoumarin (7-甲氧基香豆素) | 531-59-9 | 10.28 | 177.1 | 121.1*, 133.1 | 50 | 30, 25 | + |
33 | carbromal (卡溴脲) | 77-65-6 | 10.87 | 237.0 | 194.1*, 114.2 | 35 | 12, 15 | + |
34 | acrivastine (阿伐斯汀) | 87848-99-5 | 11.17 | 349.2 | 278.2*, 232.3 | 50 | 25, 50 | + |
35 | erythromycin (红霉素) | 114-07-8 | 11.20 | 734.5 | 158.2*, 116.2 | 45 | 50, 60 | + |
36 | haloperidol (氟哌啶醇) | 52-86-8 | 11.21 | 376.9 | 123.1*, 164.9 | 25 | 40, 34 | + |
37 | nalidixic acid (萘啶酸) | 389-08-2 | 11.22 | 233.1 | 215.1*, 187.1 | 30 | 20, 35 | + |
38 | xylometazoline (赛洛唑啉) | 1218-35-5 | 11.43 | 245.1 | 145.1*, 229.2 | 35 | 38, 36 | + |
39 | diphenylpyraline (二苯拉林) | 147-20-6 | 11.56 | 282.2 | 167.1*, 116.2 | 50 | 35, 45 | + |
40 | 7-methylcoumarin (7-甲基香豆素) | 2445-83-2 | 11.82 | 161.1 | 105.1*, 117.1 | 50 | 25, 20 | + |
41 | flumequine (氟甲喹) | 42835-25-6 | 12.03 | 262.1 | 244.2*, 202.1 | 40 | 25, 45 | + |
42 | propyphenazone (异丙安替比林) | 479-92-5 | 12.66 | 231.0 | 189.0*, 201.1 | 30 | 20, 22 | + |
43 | fluoxymesterone (氟甲睾酮) | 76-43-7 | 13.21 | 337.3 | 281.1*, 241.2 | 30 | 20, 23 | + |
44 | mifepristone (米非司酮) | 84371-65-3 | 13.23 | 430.4 | 134.1*, 121.6 | 62 | 30, 20 | + |
45 | adrenosterone (肾上腺甾酮) | 382-45-6 | 13.33 | 301.3 | 257.3*, 121.2 | 40 | 21, 26 | + |
46 | fexofenadine (非索非那定) | 153439-40-8 | 13.60 | 502.3 | 171.2*, 466.4 | 60 | 50, 40 | + |
47 | trenbolone (群勃龙) | 10161-33-8 | 13.72 | 271.2 | 253.2*, 199.1 | 44 | 19, 22 | + |
48 | chlorphenoxamine (氯苯沙明) | 77-38-3 | 14.05 | 304.2 | 215.1*, 90.1 | 30 | 20, 10 | + |
49 | boldenone (勃地酮) | 846-48-0 | 14.56 | 287.2 | 135.2*, 269.1 | 35 | 18, 12 | + |
50 | nandrolone (诺龙) | 434-22-0 | 15.02 | 275.2 | 109.1*, 257.2 | 30 | 27, 14 | + |
51 | androstadienedione (1,4-雄烯二酮) | 897-06-3 | 15.76 | 285.2 | 121.1*, 147.2 | 4 | 22, 12 | + |
52 | 7-ethoxy-4-methylcoumarin (7-乙氧基-4-甲基香豆素) | 87-05-8 | 15.85 | 205.1 | 177.1*, 121.1 | 50 | 25, 35 | + |
53 | methandrostenolone (美雄酮) | 72-63-9 | 15.91 | 301.2 | 121.2*, 149.2 | 30 | 25, 13 | + |
54 | stanozolol (司坦唑醇) | 10418-03-8 | 16.20 | 329.2 | 81.2*, 95.1 | 82 | 42, 38 | + |
55 | terbinafine (特比萘芬) | 78628-80-5 | 16.33 | 292.2 | 141.1*, 93.1 | 40 | 25, 25 | + |
56 | norethisterone (炔诺酮) | 68-22-4 | 17.26 | 299.1 | 109.1*, 91.1 | 40 | 25, 38 | + |
57 | flugestone acetate (氟孕酮醋酸酯) | 2529-45-5 | 17.61 | 407.3 | 225.2*, 285.2 | 72 | 24, 20 | + |
58 | 21-hydroxyprogesterone (21-羟基孕酮) | 64-85-7 | 18.09 | 331.2 | 108.8*, 97.0 | 45 | 25, 30 | + |
59 | androstenedione (雄烯二酮) | 63-05-8 | 18.78 | 287.2 | 97.1*, 109.2 | 35 | 21, 24 | + |
60 | ethisterone (炔孕酮) | 434-03-7 | 19.22 | 313.3 | 109.2*, 97.1 | 30 | 25, 21 | + |
61 | epitestosterone (表睾酮) | 481-30-1 | 19.39 | 289.1 | 109.1*, 97.1 | 48 | 26, 20 | + |
62 | 17-α-hydroxyprogesterone (17-α-羟基孕酮) | 68-96-2 | 19.42 | 331.5 | 109.2*, 97.1 | 30 | 26, 24 | + |
63 | acenocoumarol (醋硝香豆素) | 152-72-7 | 19.49 | 354.1 | 163.1*, 296.1 | 50 | 25, 25 | + |
64 | drospirenone (屈螺酮) | 67392-87-4 | 20.03 | 367.3 | 97.1*, 105.2 | 45 | 23, 38 | + |
65 | altrenogest (四烯雌酮) | 850-52-2 | 20.28 | 311.2 | 227.2*, 269.2 | 50 | 24, 13 | + |
66 | megestrol (甲地孕酮) | 3562-63-8 | 20.52 | 343.3 | 325.1*, 187.1 | 56 | 16, 20 | + |
67 | clostebol (氯司替勃) | 1093-58-9 | 20.60 | 323.3 | 143.1*, 131.1 | 38 | 25, 25 | + |
68 | medroxyprogesterone (甲羟孕酮) | 520-85-4 | 21.19 | 345.2 | 123.2*, 97.0 | 30 | 24, 25 | + |
69 | dydrogesterone (去氢孕酮) | 152-62-5 | 21.47 | 313.3 | 295.2*, 173.1 | 20 | 12, 23 | + |
70 | 17-α-hydroxyprogesterone 17-acetate (17-α-羟基孕酮-17-醋酸酯) | 302-23-8 | 21.77 | 373.3 | 313.3*, 271.2 | 52 | 12, 16 | + |
71 | ebastine (依巴斯汀) | 90729-43-4 | 22.03 | 470.3 | 167.2*, 203.2 | 60 | 45, 45 | + |
72 | trenbolone-acetate (醋酸群勃龙) | 10161-34-9 | 22.17 | 313.3 | 253.2*, 107.1 | 15 | 19, 31 | + |
73 | phenylbutazone (保泰松) | 50-33-9 | 22.28 | 309.1 | 120.1*, 92.1 | 30 | 28, 36 | + |
74 | isoimperatorin (异欧前胡素) | 482-45-1 | 22.54 | 271.1 | 203.1*, 69.1 | 30 | 15, 30 | + |
75 | norethisterone acetate (炔诺酮醋酸盐) | 51-98-9 | 22.66 | 341.3 | 281.2*, 109.1 | 35 | 15, 28 | + |
76 | danazol (达那唑) | 17230-88-5 | 22.70 | 338.4 | 148.2*, 120.3 | 30 | 23, 30 | + |
77 | pyranocumarin (环香豆素) | 518-20-7 | 23.33 | 323.2 | 251.1*, 73.0 | 45 | 25, 25 | + |
78 | testosterone-17-acetate (17-乙酸睾丸激素) | 1045-69-8 | 23.79 | 331.5 | 109.1*, 97.2 | 20 | 27, 21 | + |
79 | 19-nortestosterone 17-propionate (丙酸诺龙) | 7207-92-3 | 24.55 | 331.4 | 257.2*, 109.1 | 48 | 14, 28 | + |
80 | clostebol acetate (醋酸氯睾酮) | 855-19-6 | 24.89 | 365.2 | 305.2*, 143.1 | 42 | 11, 25 | + |
81 | testosterone propionate (丙酸睾酮) | 57-85-2 | 25.15 | 345.2 | 97.1*, 109.2 | 38 | 22, 25 | + |
82 | nandrolone phenylpropionate (苯丙酸诺龙) | 62-90-8 | 26.44 | 407.2 | 105.2*, 257.1 | 35 | 26, 16 | + |
83 | atranol (苔黑醛) | 526-37-4 | 9.96 | 151.0 | 123.1*, 81.0 | 10 | 15, 13 | - |
84 | chlorzoxazone (氯唑沙宗) | 95-25-0 | 10.01 | 168.0 | 132.1*, 76.1 | 50 | 25, 30 | - |
85 | chloroatranol (氯化苔黑醛) | 57074-21-2 | 13.80 | 185.0 | 157.0*, 93.1 | 35 | 13, 19 | - |
86 | dienestrol (双烯雌酚) | 84-17-3 | 20.62 | 265.2 | 93.0*, 249.0 | 50 | 25, 24 | - |
87 | hexestrol (己烷雌酚) | 84-16-2 | 20.73 | 269.2 | 119.0*, 133.0 | 37 | 37, 15 | - |
表1 87种禁用原料的CAS号、保留时间和质谱参数
Table 1 CAS Nos., retention times and MS parameters of the 87 prohibited ingredients
No. | Compound | CAS No. | Retention time/min | Parent ion (m/z) | Daughter ions (m/z) | CV/ V | CEs/ eV | ESI mode |
---|---|---|---|---|---|---|---|---|
1 | ranitidine (雷尼替丁) | 66357-59-3 | 2.67 | 315.2 | 176.1*, 130.1 | 45 | 25, 45 | + |
2 | sulfacetamide (磺胺醋酰) | 144-80-9 | 3.02 | 215.1 | 156.0*, 92.1 | 30 | 15, 30 | + |
3 | dimetridazole (二甲硝咪唑) | 551-92-8 | 3.48 | 142.0 | 96.0*, 81.0 | 45 | 20, 30 | + |
4 | ronidazole (洛硝达唑) | 7681-76-7 | 3.68 | 201.1 | 140.1*, 55.1 | 25 | 15, 30 | + |
5 | sulfadiazine (磺胺嘧啶) | 68-35-9 | 3.93 | 251.1 | 92.1*, 156.1 | 40 | 35, 25 | + |
6 | emedastine (依美斯汀) | 87233-62-3 | 4.76 | 303.3 | 246.2*, 174.2 | 60 | 30, 40 | + |
7 | doxylamine (多西拉敏) | 469-21-6 | 5.48 | 271.2 | 182.2*, 167.2 | 30 | 20, 40 | + |
8 | trimethoprim (甲氧苄啶) | 738-70-5 | 5.58 | 291.2 | 123.1*, 230.2 | 60 | 30, 30 | + |
9 | marbofloxacin (麻保沙星) | 115550-35-1 | 5.61 | 363.1 | 72.1*, 320.2 | 50 | 35, 25 | + |
10 | tinidazole (替硝唑) | 19387-91-8 | 5.63 | 248.1 | 121.0*, 128.0 | 45 | 20, 30 | + |
11 | lomefloxacin (洛美沙星) | 98079-52-8 | 5.99 | 352.2 | 265.2*, 308.2 | 50 | 35, 25 | + |
12 | danofloxacin (达氟沙星) | 112398-08-0 | 6.00 | 358.2 | 340.2*, 96.1 | 55 | 35, 40 | + |
13 | methoxyphenamine (甲氧那明) | 5588-10-3 | 6.01 | 180.2 | 121.1*, 149.1 | 35 | 25, 15 | + |
14 | sulfamethazine (磺胺二甲嘧啶) | 57-68-1 | 6.09 | 279.1 | 186.1*, 156.0 | 40 | 25, 25 | + |
15 | orbifloxacin (奥比沙星) | 113617-63-3 | 6.24 | 396.1 | 352.2*, 295.2 | 50 | 25, 35 | + |
16 | naphazoline (萘甲唑啉) | 550-99-2 | 6.27 | 211.3 | 141.1*, 115.1 | 35 | 28, 37 | + |
17 | ornidazole (奥硝唑) | 16773-42-5 | 6.28 | 220.1 | 128.1*, 82.1 | 45 | 20, 40 | + |
18 | gatifloxacin (加替沙星) | 112811-59-3 | 6.41 | 376.2 | 261.2*, 332.2 | 50 | 40, 25 | + |
19 | sparfloxacin (司帕沙星) | 110871-86-8 | 6.70 | 393.2 | 349.2*, 292.2 | 60 | 30, 40 | + |
20 | methapyrilene (美沙吡林) | 135-23-9 | 6.88 | 262.2 | 97.1*, 217.1 | 35 | 35, 20 | + |
21 | cinoxacin (西诺沙星) | 28657-80-9 | 7.61 | 263.1 | 245.1*, 189.1 | 40 | 20, 40 | + |
22 | triprolidine (曲普利啶) | 6138-79-0 | 8.13 | 279.2 | 208.2*, 193.2 | 30 | 20, 45 | + |
23 | bromisoval (溴米索伐) | 496-67-3 | 8.27 | 223.5 | 179.9*, 57.1 | 30 | 10, 18 | + |
24 | xanthotol (8-羟基补骨脂素) | 2009-24-7 | 8.33 | 203.1 | 147.1*, 131.1 | 50 | 30, 30 | + |
25 | ketotifen (酮替芬) | 34580-14-8 | 8.34 | 310.1 | 96.1*, 97.1 | 60 | 40, 50 | + |
26 | phenacetin (非那西丁) | 62-44-2 | 8.38 | 180.1 | 110.2*, 138.1 | 30 | 18, 15 | + |
27 | oxolinic (恶喹酸) | 14698-29-4 | 8.51 | 262.1 | 244.1*, 216.1 | 30 | 25, 40 | + |
28 | mizolastine (咪唑斯汀) | 108612-45-9 | 8.78 | 433.3 | 109.1*, 308.3 | 50 | 55, 35 | + |
29 | olopatadine (奥洛他定) | 140462-76-6 | 9.77 | 338.3 | 247.2*, 165.1 | 50 | 30, 35 | + |
30 | decloxizine (去氯羟嗪) | 13073-96-6 | 10.09 | 341.2 | 167.1*, 152.2 | 40 | 25, 60 | + |
31 | chlomezanone (氯美扎酮) | 80-77-3 | 10.24 | 274.2 | 154.2*, 209.2 | 30 | 15, 12 | + |
32 | 7-methoxycoumarin (7-甲氧基香豆素) | 531-59-9 | 10.28 | 177.1 | 121.1*, 133.1 | 50 | 30, 25 | + |
33 | carbromal (卡溴脲) | 77-65-6 | 10.87 | 237.0 | 194.1*, 114.2 | 35 | 12, 15 | + |
34 | acrivastine (阿伐斯汀) | 87848-99-5 | 11.17 | 349.2 | 278.2*, 232.3 | 50 | 25, 50 | + |
35 | erythromycin (红霉素) | 114-07-8 | 11.20 | 734.5 | 158.2*, 116.2 | 45 | 50, 60 | + |
36 | haloperidol (氟哌啶醇) | 52-86-8 | 11.21 | 376.9 | 123.1*, 164.9 | 25 | 40, 34 | + |
37 | nalidixic acid (萘啶酸) | 389-08-2 | 11.22 | 233.1 | 215.1*, 187.1 | 30 | 20, 35 | + |
38 | xylometazoline (赛洛唑啉) | 1218-35-5 | 11.43 | 245.1 | 145.1*, 229.2 | 35 | 38, 36 | + |
39 | diphenylpyraline (二苯拉林) | 147-20-6 | 11.56 | 282.2 | 167.1*, 116.2 | 50 | 35, 45 | + |
40 | 7-methylcoumarin (7-甲基香豆素) | 2445-83-2 | 11.82 | 161.1 | 105.1*, 117.1 | 50 | 25, 20 | + |
41 | flumequine (氟甲喹) | 42835-25-6 | 12.03 | 262.1 | 244.2*, 202.1 | 40 | 25, 45 | + |
42 | propyphenazone (异丙安替比林) | 479-92-5 | 12.66 | 231.0 | 189.0*, 201.1 | 30 | 20, 22 | + |
43 | fluoxymesterone (氟甲睾酮) | 76-43-7 | 13.21 | 337.3 | 281.1*, 241.2 | 30 | 20, 23 | + |
44 | mifepristone (米非司酮) | 84371-65-3 | 13.23 | 430.4 | 134.1*, 121.6 | 62 | 30, 20 | + |
45 | adrenosterone (肾上腺甾酮) | 382-45-6 | 13.33 | 301.3 | 257.3*, 121.2 | 40 | 21, 26 | + |
46 | fexofenadine (非索非那定) | 153439-40-8 | 13.60 | 502.3 | 171.2*, 466.4 | 60 | 50, 40 | + |
47 | trenbolone (群勃龙) | 10161-33-8 | 13.72 | 271.2 | 253.2*, 199.1 | 44 | 19, 22 | + |
48 | chlorphenoxamine (氯苯沙明) | 77-38-3 | 14.05 | 304.2 | 215.1*, 90.1 | 30 | 20, 10 | + |
49 | boldenone (勃地酮) | 846-48-0 | 14.56 | 287.2 | 135.2*, 269.1 | 35 | 18, 12 | + |
50 | nandrolone (诺龙) | 434-22-0 | 15.02 | 275.2 | 109.1*, 257.2 | 30 | 27, 14 | + |
51 | androstadienedione (1,4-雄烯二酮) | 897-06-3 | 15.76 | 285.2 | 121.1*, 147.2 | 4 | 22, 12 | + |
52 | 7-ethoxy-4-methylcoumarin (7-乙氧基-4-甲基香豆素) | 87-05-8 | 15.85 | 205.1 | 177.1*, 121.1 | 50 | 25, 35 | + |
53 | methandrostenolone (美雄酮) | 72-63-9 | 15.91 | 301.2 | 121.2*, 149.2 | 30 | 25, 13 | + |
54 | stanozolol (司坦唑醇) | 10418-03-8 | 16.20 | 329.2 | 81.2*, 95.1 | 82 | 42, 38 | + |
55 | terbinafine (特比萘芬) | 78628-80-5 | 16.33 | 292.2 | 141.1*, 93.1 | 40 | 25, 25 | + |
56 | norethisterone (炔诺酮) | 68-22-4 | 17.26 | 299.1 | 109.1*, 91.1 | 40 | 25, 38 | + |
57 | flugestone acetate (氟孕酮醋酸酯) | 2529-45-5 | 17.61 | 407.3 | 225.2*, 285.2 | 72 | 24, 20 | + |
58 | 21-hydroxyprogesterone (21-羟基孕酮) | 64-85-7 | 18.09 | 331.2 | 108.8*, 97.0 | 45 | 25, 30 | + |
59 | androstenedione (雄烯二酮) | 63-05-8 | 18.78 | 287.2 | 97.1*, 109.2 | 35 | 21, 24 | + |
60 | ethisterone (炔孕酮) | 434-03-7 | 19.22 | 313.3 | 109.2*, 97.1 | 30 | 25, 21 | + |
61 | epitestosterone (表睾酮) | 481-30-1 | 19.39 | 289.1 | 109.1*, 97.1 | 48 | 26, 20 | + |
62 | 17-α-hydroxyprogesterone (17-α-羟基孕酮) | 68-96-2 | 19.42 | 331.5 | 109.2*, 97.1 | 30 | 26, 24 | + |
63 | acenocoumarol (醋硝香豆素) | 152-72-7 | 19.49 | 354.1 | 163.1*, 296.1 | 50 | 25, 25 | + |
64 | drospirenone (屈螺酮) | 67392-87-4 | 20.03 | 367.3 | 97.1*, 105.2 | 45 | 23, 38 | + |
65 | altrenogest (四烯雌酮) | 850-52-2 | 20.28 | 311.2 | 227.2*, 269.2 | 50 | 24, 13 | + |
66 | megestrol (甲地孕酮) | 3562-63-8 | 20.52 | 343.3 | 325.1*, 187.1 | 56 | 16, 20 | + |
67 | clostebol (氯司替勃) | 1093-58-9 | 20.60 | 323.3 | 143.1*, 131.1 | 38 | 25, 25 | + |
68 | medroxyprogesterone (甲羟孕酮) | 520-85-4 | 21.19 | 345.2 | 123.2*, 97.0 | 30 | 24, 25 | + |
69 | dydrogesterone (去氢孕酮) | 152-62-5 | 21.47 | 313.3 | 295.2*, 173.1 | 20 | 12, 23 | + |
70 | 17-α-hydroxyprogesterone 17-acetate (17-α-羟基孕酮-17-醋酸酯) | 302-23-8 | 21.77 | 373.3 | 313.3*, 271.2 | 52 | 12, 16 | + |
71 | ebastine (依巴斯汀) | 90729-43-4 | 22.03 | 470.3 | 167.2*, 203.2 | 60 | 45, 45 | + |
72 | trenbolone-acetate (醋酸群勃龙) | 10161-34-9 | 22.17 | 313.3 | 253.2*, 107.1 | 15 | 19, 31 | + |
73 | phenylbutazone (保泰松) | 50-33-9 | 22.28 | 309.1 | 120.1*, 92.1 | 30 | 28, 36 | + |
74 | isoimperatorin (异欧前胡素) | 482-45-1 | 22.54 | 271.1 | 203.1*, 69.1 | 30 | 15, 30 | + |
75 | norethisterone acetate (炔诺酮醋酸盐) | 51-98-9 | 22.66 | 341.3 | 281.2*, 109.1 | 35 | 15, 28 | + |
76 | danazol (达那唑) | 17230-88-5 | 22.70 | 338.4 | 148.2*, 120.3 | 30 | 23, 30 | + |
77 | pyranocumarin (环香豆素) | 518-20-7 | 23.33 | 323.2 | 251.1*, 73.0 | 45 | 25, 25 | + |
78 | testosterone-17-acetate (17-乙酸睾丸激素) | 1045-69-8 | 23.79 | 331.5 | 109.1*, 97.2 | 20 | 27, 21 | + |
79 | 19-nortestosterone 17-propionate (丙酸诺龙) | 7207-92-3 | 24.55 | 331.4 | 257.2*, 109.1 | 48 | 14, 28 | + |
80 | clostebol acetate (醋酸氯睾酮) | 855-19-6 | 24.89 | 365.2 | 305.2*, 143.1 | 42 | 11, 25 | + |
81 | testosterone propionate (丙酸睾酮) | 57-85-2 | 25.15 | 345.2 | 97.1*, 109.2 | 38 | 22, 25 | + |
82 | nandrolone phenylpropionate (苯丙酸诺龙) | 62-90-8 | 26.44 | 407.2 | 105.2*, 257.1 | 35 | 26, 16 | + |
83 | atranol (苔黑醛) | 526-37-4 | 9.96 | 151.0 | 123.1*, 81.0 | 10 | 15, 13 | - |
84 | chlorzoxazone (氯唑沙宗) | 95-25-0 | 10.01 | 168.0 | 132.1*, 76.1 | 50 | 25, 30 | - |
85 | chloroatranol (氯化苔黑醛) | 57074-21-2 | 13.80 | 185.0 | 157.0*, 93.1 | 35 | 13, 19 | - |
86 | dienestrol (双烯雌酚) | 84-17-3 | 20.62 | 265.2 | 93.0*, 249.0 | 50 | 25, 24 | - |
87 | hexestrol (己烷雌酚) | 84-16-2 | 20.73 | 269.2 | 119.0*, 133.0 | 37 | 37, 15 | - |
图2 乳液膏霜类基质中87种禁用原料在不同提取溶剂下的加标回收率(n=6)
Fig. 2 Spiked recoveries of the 87 prohibited ingredients with different extraction solvents in cream matrix (n=6) Compound Nos. 1-87 were the same as those in Table 1.
图3 油基类基质中87种禁用原料在不同提取溶剂下的加标回收率(n=6)
Fig. 3 Spiked recoveries of the 87 prohibited ingredients with different extraction solvents in oil matrix (n=6) Compound Nos. 1-87 were the same as those in Table 1.
图4 水基类、乳液膏霜类和油基类样品中87种禁用原料的基质效应
Fig. 4 Matrix effects of the 87 prohibited ingredients in toner, cream and oil matrices Compound Nos. 1-87 were the same as those in Table 1.
Compound | Linear range/ (μg/L) | LOD/ (μg/g) | LOQ/ (μg/g) | Toner matrix | Cream matrix | Oil matrix | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Linear equation | r | Linear equation | r | Linear equation | r | |||||||||||
Ranitidine | 15.25-228.79 | 0.31 | 0.92 | y=2400.5x-1496.4 | 0.9989 | y=2371.8x-10514.9 | 0.9993 | y=2358.5x-10101.2 | 0.9994 | |||||||
Sulfacetamide | 16.80-252.02 | 0.34 | 1.01 | y=5655.2x+16422.6 | 0.9992 | y=5010.9x+25181.9 | 0.9984 | y=5470.7x+25042.9 | 0.9986 | |||||||
Dimetridazole | 15.98-239.66 | 0.32 | 0.96 | y=15697.5x-34887.1 | 0.9997 | y=12726.0x+34942.1 | 0.9995 | y=14481.4x+4299.7 | 0.9993 | |||||||
Ronidazole | 16.41-246.16 | 0.33 | 0.98 | y=13107.9x+6208.7 | 0.9999 | y=12348.8x+60793.4 | 0.9984 | y=12810.3x+62525.9 | 0.9989 | |||||||
Sulfadiazine | 16.06-240.93 | 0.32 | 0.96 | y=6018.8x+2753.8 | 0.9988 | y=6866.5x+28266.4 | 0.9992 | y=6244.0x+27850.5 | 0.9981 | |||||||
Emedastine | 15.47-232.12 | 0.31 | 0.93 | y=3170.6x+51874.7 | 0.9963 | y=5620.6x-7541.9 | 0.9976 | y=3177.8x+48455.1 | 0.9966 | |||||||
Doxylamine | 4.51-67.66 | 0.09 | 0.27 | y=68123.4x-11920.7 | 0.9996 | y=75952.9x-112280.0 | 0.9996 | y=63840.7x+11006.1 | 0.9994 | |||||||
Trimethoprim | 5.54-83.16 | 0.11 | 0.33 | y=26457.0x+35841.3 | 0.9985 | y=26170.3x+27613.1 | 0.9991 | y=27473.0x+33170.0 | 0.9983 | |||||||
Marbofloxacin | 15.66-234.92 | 0.31 | 0.94 | y=1848.5x+9219.7 | 0.9992 | y=2308.9x+1108.7 | 0.9992 | y=1423.4x+18920.6 | 0.9978 | |||||||
Tinidazole | 4.59-68.87 | 0.09 | 0.28 | y=11224.3x+23945.1 | 0.9969 | y=11271.9x+25361.7 | 0.9982 | y=12047.2x+17744.2 | 0.9986 | |||||||
Lomefloxacin | 3.99-59.81 | 0.08 | 0.24 | y=5811.0x+6712.0 | 0.9983 | y=5836.8x+2574.9 | 0.9984 | y=5393.4x+6501.9 | 0.9989 | |||||||
Danofloxacin | 18.57-278.55 | 0.37 | 1.11 | y=3534.7x+43071.5 | 0.9964 | y=5806.4x+1135.3 | 0.9963 | y=2419.9x+57441.7 | 0.9963 | |||||||
Methoxyphenamine | 4.10-61.52 | 0.08 | 0.25 | y=44721.5x+30419.8 | 0.9988 | y=42119.0x-5667.9 | 0.9997 | y=41860.9x+48782.6 | 0.9982 | |||||||
Sulfamethazine | 5.07-76.12 | 0.10 | 0.30 | y=11464.0x+15139.4 | 0.9967 | y=12296.6x+31394.0 | 0.9972 | y=12280.0x+19579.1 | 0.9995 | |||||||
Orbifloxacin | 5.54-83.14 | 0.11 | 0.33 | y=4629.2x-155.1 | 0.9992 | y=7836.9x+7377.6 | 0.9980 | y=7760.0x+6785.2 | 0.9991 | |||||||
Naphazoline | 5.26-78.91 | 0.11 | 0.32 | y=79884.8x+13503.5 | 0.9988 | y=82114.5x-6091.3 | 0.9994 | y=80275.8x+100938.0 | 0.9989 | |||||||
Ornidazole | 5.02-75.37 | 0.10 | 0.30 | y=18999.4x+7662.7 | 0.9986 | y=20769.3x+30261.8 | 0.9997 | y=23909.7x+9342.8 | 0.9994 | |||||||
Gatifloxacin | 5.64-84.66 | 0.11 | 0.34 | y=5899.3x+984.0 | 0.9998 | y=7174.3x-6411.5 | 0.9993 | y=6526.4x+2898.8 | 0.9993 | |||||||
Sparfloxacin | 5.51-82.71 | 0.11 | 0.33 | y=2657.9x+1094.8 | 0.9991 | y=2198.2x+536.8 | 0.9987 | y=2537.4x-1482.1 | 0.9990 | |||||||
Methapyrilene | 5.65-84.70 | 0.11 | 0.34 | y=59277.8x-21777.6 | 0.9996 | y=60609.8x-88707.0 | 0.9997 | y=56854.6x-9936.5 | 0.9998 | |||||||
Cinoxacin | 5.45-81.82 | 0.11 | 0.33 | y=28237.6x+30786.1 | 0.9980 | y=29013.5x+23560.8 | 0.9991 | y=30206.0x+6551.5 | 0.9976 | |||||||
Triprolidine | 3.55-53.32 | 0.07 | 0.21 | y=127241.0x-153180.0 | 0.9969 | y=125875.0x-133665.0 | 0.9986 | y=124424.0x-41976.7 | 0.9998 | |||||||
Bromisoval | 14.54-218.10 | 0.29 | 0.87 | y=1389.4x-22.3 | 0.9982 | y=1256.0x+3161.5 | 0.9990 | y=1338.4x-222.0 | 0.9994 | |||||||
Xanthotol | 14.38-215.65 | 0.29 | 0.86 | y=6562.7x+19098.0 | 0.9984 | y=6431.5x+15426.4 | 0.9987 | y=6740.5x+4341.0 | 0.9990 | |||||||
Ketotifen | 13.75-206.24 | 0.27 | 0.82 | y=12863.0x+40377.9 | 0.9992 | y=11579.5x+24740.0 | 0.9991 | y=12917.4x+51614.2 | 0.9990 | |||||||
Phenacetin | 6.32-94.86 | 0.13 | 0.38 | y=65253.3x+222964.0 | 0.9987 | y=62330.3x+270544.0 | 0.9960 | y=68191.9x+204305.0 | 0.9987 | |||||||
Oxolinic | 5.14-77.10 | 0.10 | 0.31 | y=158433.0x+188163.0 | 0.9994 | y=151001.0x+270534.0 | 0.9979 | y=152449.0x+242155.0 | 0.9974 | |||||||
Mizolastine | 16.26-243.86 | 0.33 | 0.98 | y=6281.3x+30442.4 | 0.9984 | y=6307.9x+29549.3 | 0.9978 | y=5662.5x+40439.6 | 0.9985 | |||||||
Olopatadine | 3.98-59.77 | 0.08 | 0.24 | y=15869.8x-920.2 | 0.9995 | y=15352.8x+9094.2 | 0.9985 | y=14947.1x+2584.8 | 0.9997 | |||||||
Decloxizine | 3.85-57.68 | 0.08 | 0.23 | y=142884.0x+13327.1 | 0.9994 | y=140014.0x-63284.8 | 0.9996 | y=143375.0x+35927.1 | 0.9995 | |||||||
Chlomezanone | 4.44-66.61 | 0.09 | 0.27 | y=5611.4x-5526.4 | 0.9984 | y=5109.9x+1581.5 | 0.9984 | y=5388.9x-200.9 | 0.9992 | |||||||
7-Methoxycoumarin | 4.47-67.12 | 0.09 | 0.27 | y=10411.2x-1891.4 | 0.9970 | y=9349.2x+18744.4 | 0.9957 | y=9384.9x+11304.2 | 0.9962 | |||||||
Carbromal | 15.37-230.60 | 0.31 | 0.92 | y=5335.2x-2853.5 | 0.9993 | y=4815.5x+11084.2 | 0.9967 | y=5017.0x+4838.6 | 0.9997 | |||||||
Acrivastine | 6.10-91.56 | 0.12 | 0.37 | y=64002.7x+74835.0 | 0.9998 | y=63540.8x+92476.5 | 0.9992 | y=63142.6x+120966.0 | 0.9987 | |||||||
Erythromycin | 5.12-76.75 | 0.10 | 0.31 | y=953.5x-132.1 | 0.9992 | y=1900.3x-1060.9 | 0.9997 | y=1968.6x+584.4 | 0.9990 | |||||||
Haloperidol | 5.65-84.71 | 0.11 | 0.34 | y=12113.3x+7007.9 | 0.9993 | y=11956.4x-1775.2 | 0.9992 | y=12072.1x+17832.2 | 0.9984 | |||||||
Nalidixic acid | 4.72-70.78 | 0.09 | 0.28 | y=114282.0x+158470.0 | 0.9979 | y=111433.0x+222548.0 | 0.9967 | y=106571.0x+235781.0 | 0.9955 | |||||||
Xylometazoline | 4.51-67.60 | 0.09 | 0.27 | y=41113.4x-21400.5 | 0.9993 | y=38636.3x-10143.7 | 0.9999 | y=39005.2x+21841.1 | 0.9994 | |||||||
Diphenylpyraline | 7.05-105.71 | 0.14 | 0.42 | y=38932.7x+18564.1 | 0.9986 | y=38944.9x-37850.1 | 0.9999 | y=39950.7x-4436.5 | 0.9998 | |||||||
7-Methylcoumarin | 15.56-233.36 | 0.31 | 0.93 | y=11331.4x+14817.6 | 0.9988 | y=10369.9x+74516.1 | 0.9956 | y=11659.7x+2476.0 | 0.9987 | |||||||
Flumequine | 4.71-70.58 | 0.09 | 0.28 | y=101785.0x-5403.1 | 0.9994 | y=101650.0x+142349.0 | 0.9978 | y=102633.0x+19800.3 | 0.9991 | |||||||
Propyphenazone | 5.55-83.32 | 0.11 | 0.33 | y=66402.5x-9161.4 | 0.9994 | y=67412.6x+19580.2 | 0.9998 | y=63838.9x+61146.7 | 0.9976 | |||||||
Fluoxymesterone | 5.68-85.22 | 0.11 | 0.34 | y=7763.0x+11353.0 | 0.9989 | y=7816.1x+5969.4 | 0.9976 | y=7471.3x+12366.5 | 0.9978 | |||||||
Mifepristone | 5.20-77.98 | 0.10 | 0.31 | y=7090.3x+841.9 | 0.9993 | y=7342.8x+1728.8 | 0.9998 | y=6849.7x+6782.7 | 0.9995 | |||||||
Adrenosterone | 5.40-80.96 | 0.11 | 0.32 | y=6614.1x+513.5 | 0.9998 | y=6337.8x+1689.5 | 0.9993 | y=6393.6x+649.3 | 0.9998 | |||||||
Fexofenadine | 4.67-69.99 | 0.09 | 0.28 | y=14943.9x-4626.7 | 0.9998 | y=14519.7x+5913.2 | 0.9996 | y=14518.8x+6640.2 | 0.9996 | |||||||
Trenbolone | 4.82-72.30 | 0.10 | 0.29 | y=28289.9x+13253.3 | 0.9998 | y=27203.6x+28073.8 | 0.9994 | y=27708.2x+28165.8 | 0.9988 | |||||||
Chlorphenoxamine | 5.78-86.70 | 0.12 | 0.35 | y=33011.9x+13211.3 | 0.9983 | y=30879.6x+5884.6 | 0.9995 | y=32308.3x+15505.9 | 0.9998 | |||||||
Boldenone | 4.68-70.25 | 0.09 | 0.28 | y=21329.8x+4785.4 | 0.9992 | y=20527.8x+18611.3 | 0.9996 | y=20910.1x+14683.9 | 0.9998 | |||||||
Nandrolone | 4.99-74.81 | 0.10 | 0.30 | y=16292.4x+2586.5 | 0.9998 | y=15448.8x+13140.9 | 0.9989 | y=15617.8x+5944.4 | 0.9990 | |||||||
Androstadienedione | 5.15-77.28 | 0.10 | 0.31 | y=31777.1x+8254.4 | 0.9990 | y=30788.0x+18216.5 | 0.9997 | y=30545.9x+13699.2 | 0.9992 | |||||||
7-Ethoxy-4-methylcoumarin | 4.87-73.07 | 0.10 | 0.29 | y=43641.5x+15783.9 | 0.9988 | y=43085.9x+34108.2 | 0.9992 | y=40114.7x+33667.4 | 0.9975 | |||||||
Methandrostenolone | 6.26-93.87 | 0.13 | 0.38 | y=39037.2x+29478.0 | 0.9993 | y=37294.2x+48834.3 | 0.9995 | y=37613.0x+50277.4 | 0.9989 | |||||||
Stanozolol | 5.08-76.16 | 0.10 | 0.30 | y=23296.2x-13849.9 | 0.9976 | y=22110.7x+3172.3 | 0.9997 | y=24018.3x-33.8 | 0.9998 | |||||||
Terbinafine | 4.64-69.59 | 0.09 | 0.28 | y=197883.0x-83633.2 | 0.9991 | y=189490.0x-29929.6 | 1.0000 | y=182443.0x-26887.2 | 0.9987 | |||||||
Norethisterone | 5.63-84.43 | 0.11 | 0.34 | y=12595.8x-3224.5 | 0.9999 | y=12619.3x-1615.8 | 0.9995 | y=12143.2x+122.1 | 0.9995 | |||||||
Flugestone acetate | 4.56-68.38 | 0.09 | 0.27 | y=5428.3x-1096.4 | 0.9990 | y=5306.4x-122.9 | 0.9997 | y=5163.4x+741.7 | 0.9994 | |||||||
21-Hydroxyprogesterone | 5.07-76.05 | 0.10 | 0.30 | y=11451.4x-1698.6 | 0.9982 | y=11308.7x+584.3 | 0.9996 | y=11279.0x-3156.4 | 0.9996 | |||||||
Androstenedione | 5.81-87.21 | 0.12 | 0.35 | y=17471.6x-11903.0 | 0.9981 | y=17552.1x+4557.7 | 0.9983 | y=19174.3x-3611.7 | 0.9993 | |||||||
Ethisterone | 4.38-65.63 | 0.09 | 0.26 | y=18595.7x+1074.9 | 0.9996 | y=18398.4x-2917.6 | 0.9990 | y=19414.3x-4426.9 | 0.9995 | |||||||
Epitestosterone | 4.97-74.61 | 0.10 | 0.30 | y=17060.6x-4118.5 | 0.9998 | y=16327.9x+2126.6 | 0.9995 | y=16835.2x-3733.7 | 0.9995 | |||||||
17-α-Hydroxyprogesterone | 5.33-79.96 | 0.11 | 0.32 | y=6764.9x-6818.1 | 0.9988 | y=6132.2x+739.5 | 0.9990 | y=6182.4x-711.1 | 0.9998 | |||||||
Acenocoumarol | 5.31-79.72 | 0.11 | 0.32 | y=15551.8x-4351.5 | 0.9991 | y=13520.4x-617.9 | 0.9997 | y=14995.2x-4636.0 | 0.9990 | |||||||
Drospirenone | 5.51-82.69 | 0.11 | 0.33 | y=4046.4x+3478.4 | 0.9975 | y=4249.1x+307.1 | 0.9998 | y=3911.0x+3525.2 | 0.9988 | |||||||
Altrenogest | 5.19-77.92 | 0.10 | 0.31 | y=36692.0x+2373.5 | 0.9998 | y=34430.8x+37710.6 | 0.9993 | y=35424.1x+21496.8 | 0.9992 | |||||||
Megestrol | 4.82-72.35 | 0.10 | 0.29 | y=12112.8x+1349.7 | 0.9998 | y=11814.8x+8455.0 | 0.9996 | y=12187.4x+6639.6 | 0.9989 | |||||||
Clostebol | 5.25-78.70 | 0.10 | 0.31 | y=18883.3x-8755.0 | 0.9965 | y=17434.3x+14585.8 | 0.9993 | y=18014.5x+4686.8 | 0.9974 | |||||||
Medroxyprogesterone | 5.07-76.11 | 0.10 | 0.30 | y=20956.2x-9269.3 | 0.9990 | y=19979.6x+124.1 | 0.9998 | y=21791.8x-9387.7 | 0.9984 | |||||||
Dydrogesterone | 4.92-73.87 | 0.10 | 0.30 | y=29437.4x-13658.7 | 0.9988 | y=29802.5x+8945.5 | 0.9992 | y=27343.9x+16116.6 | 0.9990 | |||||||
17-α-Hydroxyprogesterone 17-acetate | 5.44-81.67 | 0.11 | 0.33 | y=32104.7x-11354.8 | 0.9989 | y=29315.2x+22532.3 | 0.9994 | y=29553.4x+12438.3 | 0.9993 | |||||||
Ebastine | 6.35-95.30 | 0.13 | 0.38 | y=95695.6x-5086.0 | 0.9995 | y=91955.3x+20452.1 | 0.9995 | y=93525.4x+100308.0 | 0.9992 | |||||||
Trenbolone-acetate | 5.42-81.37 | 0.11 | 0.33 | y=100624.0x+65911.6 | 0.9977 | y=96363.9x-116855.0 | 0.9986 | y=99984.7x+71205.8 | 0.9988 | |||||||
Phenylbutazone | 16.71-250.60 | 0.33 | 1.00 | y=5567.8x-22493.3 | 0.9997 | y=3986.4x-30865.2 | 0.9961 | y=5291.1x-6485.3 | 0.9969 | |||||||
Isoimperatorin | 13.40-200.97 | 0.27 | 0.80 | y=51475.3x+454144.0 | 0.9986 | y=51420.2x+439348.0 | 0.9962 | y=52292.5x+380312.0 | 0.9981 | |||||||
Norethisterone acetate | 5.60-84.05 | 0.11 | 0.34 | y=14108.6x-10407.8 | 0.9966 | y=12968.4x+4816.3 | 0.9999 | y=13293.7x-2467.3 | 0.9999 | |||||||
Danazol | 6.62-99.32 | 0.13 | 0.40 | y=12354.0x+8239.5 | 0.9990 | y=11759.6x+5276.7 | 0.9992 | y=11555.5x+12133.3 | 0.9988 | |||||||
Pyranocumarin | 4.24-63.56 | 0.08 | 0.25 | y=136375.0x+208747.0 | 0.9988 | y=124269.0x+215334.0 | 0.9970 | y=140515.0x+169625.0 | 0.9997 | |||||||
Testosterone-17-acetate | 5.33-79.93 | 0.11 | 0.32 | y=9767.8x-9500.0 | 0.9992 | y=9348.0x-3651.2 | 0.9995 | y=9229.6x+4154.6 | 0.9996 | |||||||
19-Nortestosterone 17-propionate | 4.88-73.14 | 0.10 | 0.29 | y=21178.0x-19268.7 | 0.9994 | y=17754.7x+7548.0 | 0.9995 | y=22237.4x-3757.6 | 0.9997 | |||||||
Clostebol acetate | 4.70-70.57 | 0.09 | 0.28 | y=7939.0x-205.9 | 0.9995 | y=6830.8x+1177.4 | 0.9985 | y=8361.2x-2815.2 | 0.9958 | |||||||
Testosterone propionate | 5.26-78.96 | 0.11 | 0.32 | y=9055.7x-11374.1 | 0.9981 | y=7838.8x+1484.2 | 0.9999 | y=10164.9x-1759.9 | 0.9999 | |||||||
Nandrolone phenylpropionate | 5.80-86.96 | 0.12 | 0.35 | y=21438.1x-13267.2 | 0.9990 | y=15349.5x+14977.1 | 0.9988 | y=21821.7x+2993.3 | 0.9994 | |||||||
Atranol | 19.23-288.41 | 0.38 | 1.15 | y=4617.4x+38620.6 | 0.9986 | y=4623.1x+58215.1 | 0.9978 | y=4338.6x+53171.1 | 0.9972 | |||||||
Chlorzoxazone | 15.24-228.60 | 0.30 | 0.91 | y=1300.0x+4343.8 | 0.9993 | y=1286.2x+8364.5 | 0.9983 | y=1292.3x+6615.1 | 0.9988 | |||||||
Chloroatranol | 4.80-72.02 | 0.10 | 0.29 | y=6564.3x+714.3 | 0.9995 | y=6277.3x+4689.4 | 0.9995 | y=6182.5x+3986.7 | 0.9986 | |||||||
Dienestrol | 14.81-222.13 | 0.30 | 0.89 | y=299.9x-1737.4 | 0.9962 | y=262.5x+480.6 | 0.9994 | y=284.4x-114.7 | 0.9998 | |||||||
Hexestrol | 16.25-243.81 | 0.33 | 0.98 | y=70.6x-210.1 | 0.9976 | y=64.1x-119.4 | 0.9992 | y=72.7x-463.7 | 0.9983 |
表2 3种化妆品基质中87种禁用原料的线性范围、LOD、LOQ、线性方程和相关系数
Table 2 Linear ranges, limits of detection (LODs), limits of quantification (LOQs), linear equations and correlation coefficients (r) of the 87 prohibited ingredients in three cosmetic matrices
Compound | Linear range/ (μg/L) | LOD/ (μg/g) | LOQ/ (μg/g) | Toner matrix | Cream matrix | Oil matrix | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Linear equation | r | Linear equation | r | Linear equation | r | |||||||||||
Ranitidine | 15.25-228.79 | 0.31 | 0.92 | y=2400.5x-1496.4 | 0.9989 | y=2371.8x-10514.9 | 0.9993 | y=2358.5x-10101.2 | 0.9994 | |||||||
Sulfacetamide | 16.80-252.02 | 0.34 | 1.01 | y=5655.2x+16422.6 | 0.9992 | y=5010.9x+25181.9 | 0.9984 | y=5470.7x+25042.9 | 0.9986 | |||||||
Dimetridazole | 15.98-239.66 | 0.32 | 0.96 | y=15697.5x-34887.1 | 0.9997 | y=12726.0x+34942.1 | 0.9995 | y=14481.4x+4299.7 | 0.9993 | |||||||
Ronidazole | 16.41-246.16 | 0.33 | 0.98 | y=13107.9x+6208.7 | 0.9999 | y=12348.8x+60793.4 | 0.9984 | y=12810.3x+62525.9 | 0.9989 | |||||||
Sulfadiazine | 16.06-240.93 | 0.32 | 0.96 | y=6018.8x+2753.8 | 0.9988 | y=6866.5x+28266.4 | 0.9992 | y=6244.0x+27850.5 | 0.9981 | |||||||
Emedastine | 15.47-232.12 | 0.31 | 0.93 | y=3170.6x+51874.7 | 0.9963 | y=5620.6x-7541.9 | 0.9976 | y=3177.8x+48455.1 | 0.9966 | |||||||
Doxylamine | 4.51-67.66 | 0.09 | 0.27 | y=68123.4x-11920.7 | 0.9996 | y=75952.9x-112280.0 | 0.9996 | y=63840.7x+11006.1 | 0.9994 | |||||||
Trimethoprim | 5.54-83.16 | 0.11 | 0.33 | y=26457.0x+35841.3 | 0.9985 | y=26170.3x+27613.1 | 0.9991 | y=27473.0x+33170.0 | 0.9983 | |||||||
Marbofloxacin | 15.66-234.92 | 0.31 | 0.94 | y=1848.5x+9219.7 | 0.9992 | y=2308.9x+1108.7 | 0.9992 | y=1423.4x+18920.6 | 0.9978 | |||||||
Tinidazole | 4.59-68.87 | 0.09 | 0.28 | y=11224.3x+23945.1 | 0.9969 | y=11271.9x+25361.7 | 0.9982 | y=12047.2x+17744.2 | 0.9986 | |||||||
Lomefloxacin | 3.99-59.81 | 0.08 | 0.24 | y=5811.0x+6712.0 | 0.9983 | y=5836.8x+2574.9 | 0.9984 | y=5393.4x+6501.9 | 0.9989 | |||||||
Danofloxacin | 18.57-278.55 | 0.37 | 1.11 | y=3534.7x+43071.5 | 0.9964 | y=5806.4x+1135.3 | 0.9963 | y=2419.9x+57441.7 | 0.9963 | |||||||
Methoxyphenamine | 4.10-61.52 | 0.08 | 0.25 | y=44721.5x+30419.8 | 0.9988 | y=42119.0x-5667.9 | 0.9997 | y=41860.9x+48782.6 | 0.9982 | |||||||
Sulfamethazine | 5.07-76.12 | 0.10 | 0.30 | y=11464.0x+15139.4 | 0.9967 | y=12296.6x+31394.0 | 0.9972 | y=12280.0x+19579.1 | 0.9995 | |||||||
Orbifloxacin | 5.54-83.14 | 0.11 | 0.33 | y=4629.2x-155.1 | 0.9992 | y=7836.9x+7377.6 | 0.9980 | y=7760.0x+6785.2 | 0.9991 | |||||||
Naphazoline | 5.26-78.91 | 0.11 | 0.32 | y=79884.8x+13503.5 | 0.9988 | y=82114.5x-6091.3 | 0.9994 | y=80275.8x+100938.0 | 0.9989 | |||||||
Ornidazole | 5.02-75.37 | 0.10 | 0.30 | y=18999.4x+7662.7 | 0.9986 | y=20769.3x+30261.8 | 0.9997 | y=23909.7x+9342.8 | 0.9994 | |||||||
Gatifloxacin | 5.64-84.66 | 0.11 | 0.34 | y=5899.3x+984.0 | 0.9998 | y=7174.3x-6411.5 | 0.9993 | y=6526.4x+2898.8 | 0.9993 | |||||||
Sparfloxacin | 5.51-82.71 | 0.11 | 0.33 | y=2657.9x+1094.8 | 0.9991 | y=2198.2x+536.8 | 0.9987 | y=2537.4x-1482.1 | 0.9990 | |||||||
Methapyrilene | 5.65-84.70 | 0.11 | 0.34 | y=59277.8x-21777.6 | 0.9996 | y=60609.8x-88707.0 | 0.9997 | y=56854.6x-9936.5 | 0.9998 | |||||||
Cinoxacin | 5.45-81.82 | 0.11 | 0.33 | y=28237.6x+30786.1 | 0.9980 | y=29013.5x+23560.8 | 0.9991 | y=30206.0x+6551.5 | 0.9976 | |||||||
Triprolidine | 3.55-53.32 | 0.07 | 0.21 | y=127241.0x-153180.0 | 0.9969 | y=125875.0x-133665.0 | 0.9986 | y=124424.0x-41976.7 | 0.9998 | |||||||
Bromisoval | 14.54-218.10 | 0.29 | 0.87 | y=1389.4x-22.3 | 0.9982 | y=1256.0x+3161.5 | 0.9990 | y=1338.4x-222.0 | 0.9994 | |||||||
Xanthotol | 14.38-215.65 | 0.29 | 0.86 | y=6562.7x+19098.0 | 0.9984 | y=6431.5x+15426.4 | 0.9987 | y=6740.5x+4341.0 | 0.9990 | |||||||
Ketotifen | 13.75-206.24 | 0.27 | 0.82 | y=12863.0x+40377.9 | 0.9992 | y=11579.5x+24740.0 | 0.9991 | y=12917.4x+51614.2 | 0.9990 | |||||||
Phenacetin | 6.32-94.86 | 0.13 | 0.38 | y=65253.3x+222964.0 | 0.9987 | y=62330.3x+270544.0 | 0.9960 | y=68191.9x+204305.0 | 0.9987 | |||||||
Oxolinic | 5.14-77.10 | 0.10 | 0.31 | y=158433.0x+188163.0 | 0.9994 | y=151001.0x+270534.0 | 0.9979 | y=152449.0x+242155.0 | 0.9974 | |||||||
Mizolastine | 16.26-243.86 | 0.33 | 0.98 | y=6281.3x+30442.4 | 0.9984 | y=6307.9x+29549.3 | 0.9978 | y=5662.5x+40439.6 | 0.9985 | |||||||
Olopatadine | 3.98-59.77 | 0.08 | 0.24 | y=15869.8x-920.2 | 0.9995 | y=15352.8x+9094.2 | 0.9985 | y=14947.1x+2584.8 | 0.9997 | |||||||
Decloxizine | 3.85-57.68 | 0.08 | 0.23 | y=142884.0x+13327.1 | 0.9994 | y=140014.0x-63284.8 | 0.9996 | y=143375.0x+35927.1 | 0.9995 | |||||||
Chlomezanone | 4.44-66.61 | 0.09 | 0.27 | y=5611.4x-5526.4 | 0.9984 | y=5109.9x+1581.5 | 0.9984 | y=5388.9x-200.9 | 0.9992 | |||||||
7-Methoxycoumarin | 4.47-67.12 | 0.09 | 0.27 | y=10411.2x-1891.4 | 0.9970 | y=9349.2x+18744.4 | 0.9957 | y=9384.9x+11304.2 | 0.9962 | |||||||
Carbromal | 15.37-230.60 | 0.31 | 0.92 | y=5335.2x-2853.5 | 0.9993 | y=4815.5x+11084.2 | 0.9967 | y=5017.0x+4838.6 | 0.9997 | |||||||
Acrivastine | 6.10-91.56 | 0.12 | 0.37 | y=64002.7x+74835.0 | 0.9998 | y=63540.8x+92476.5 | 0.9992 | y=63142.6x+120966.0 | 0.9987 | |||||||
Erythromycin | 5.12-76.75 | 0.10 | 0.31 | y=953.5x-132.1 | 0.9992 | y=1900.3x-1060.9 | 0.9997 | y=1968.6x+584.4 | 0.9990 | |||||||
Haloperidol | 5.65-84.71 | 0.11 | 0.34 | y=12113.3x+7007.9 | 0.9993 | y=11956.4x-1775.2 | 0.9992 | y=12072.1x+17832.2 | 0.9984 | |||||||
Nalidixic acid | 4.72-70.78 | 0.09 | 0.28 | y=114282.0x+158470.0 | 0.9979 | y=111433.0x+222548.0 | 0.9967 | y=106571.0x+235781.0 | 0.9955 | |||||||
Xylometazoline | 4.51-67.60 | 0.09 | 0.27 | y=41113.4x-21400.5 | 0.9993 | y=38636.3x-10143.7 | 0.9999 | y=39005.2x+21841.1 | 0.9994 | |||||||
Diphenylpyraline | 7.05-105.71 | 0.14 | 0.42 | y=38932.7x+18564.1 | 0.9986 | y=38944.9x-37850.1 | 0.9999 | y=39950.7x-4436.5 | 0.9998 | |||||||
7-Methylcoumarin | 15.56-233.36 | 0.31 | 0.93 | y=11331.4x+14817.6 | 0.9988 | y=10369.9x+74516.1 | 0.9956 | y=11659.7x+2476.0 | 0.9987 | |||||||
Flumequine | 4.71-70.58 | 0.09 | 0.28 | y=101785.0x-5403.1 | 0.9994 | y=101650.0x+142349.0 | 0.9978 | y=102633.0x+19800.3 | 0.9991 | |||||||
Propyphenazone | 5.55-83.32 | 0.11 | 0.33 | y=66402.5x-9161.4 | 0.9994 | y=67412.6x+19580.2 | 0.9998 | y=63838.9x+61146.7 | 0.9976 | |||||||
Fluoxymesterone | 5.68-85.22 | 0.11 | 0.34 | y=7763.0x+11353.0 | 0.9989 | y=7816.1x+5969.4 | 0.9976 | y=7471.3x+12366.5 | 0.9978 | |||||||
Mifepristone | 5.20-77.98 | 0.10 | 0.31 | y=7090.3x+841.9 | 0.9993 | y=7342.8x+1728.8 | 0.9998 | y=6849.7x+6782.7 | 0.9995 | |||||||
Adrenosterone | 5.40-80.96 | 0.11 | 0.32 | y=6614.1x+513.5 | 0.9998 | y=6337.8x+1689.5 | 0.9993 | y=6393.6x+649.3 | 0.9998 | |||||||
Fexofenadine | 4.67-69.99 | 0.09 | 0.28 | y=14943.9x-4626.7 | 0.9998 | y=14519.7x+5913.2 | 0.9996 | y=14518.8x+6640.2 | 0.9996 | |||||||
Trenbolone | 4.82-72.30 | 0.10 | 0.29 | y=28289.9x+13253.3 | 0.9998 | y=27203.6x+28073.8 | 0.9994 | y=27708.2x+28165.8 | 0.9988 | |||||||
Chlorphenoxamine | 5.78-86.70 | 0.12 | 0.35 | y=33011.9x+13211.3 | 0.9983 | y=30879.6x+5884.6 | 0.9995 | y=32308.3x+15505.9 | 0.9998 | |||||||
Boldenone | 4.68-70.25 | 0.09 | 0.28 | y=21329.8x+4785.4 | 0.9992 | y=20527.8x+18611.3 | 0.9996 | y=20910.1x+14683.9 | 0.9998 | |||||||
Nandrolone | 4.99-74.81 | 0.10 | 0.30 | y=16292.4x+2586.5 | 0.9998 | y=15448.8x+13140.9 | 0.9989 | y=15617.8x+5944.4 | 0.9990 | |||||||
Androstadienedione | 5.15-77.28 | 0.10 | 0.31 | y=31777.1x+8254.4 | 0.9990 | y=30788.0x+18216.5 | 0.9997 | y=30545.9x+13699.2 | 0.9992 | |||||||
7-Ethoxy-4-methylcoumarin | 4.87-73.07 | 0.10 | 0.29 | y=43641.5x+15783.9 | 0.9988 | y=43085.9x+34108.2 | 0.9992 | y=40114.7x+33667.4 | 0.9975 | |||||||
Methandrostenolone | 6.26-93.87 | 0.13 | 0.38 | y=39037.2x+29478.0 | 0.9993 | y=37294.2x+48834.3 | 0.9995 | y=37613.0x+50277.4 | 0.9989 | |||||||
Stanozolol | 5.08-76.16 | 0.10 | 0.30 | y=23296.2x-13849.9 | 0.9976 | y=22110.7x+3172.3 | 0.9997 | y=24018.3x-33.8 | 0.9998 | |||||||
Terbinafine | 4.64-69.59 | 0.09 | 0.28 | y=197883.0x-83633.2 | 0.9991 | y=189490.0x-29929.6 | 1.0000 | y=182443.0x-26887.2 | 0.9987 | |||||||
Norethisterone | 5.63-84.43 | 0.11 | 0.34 | y=12595.8x-3224.5 | 0.9999 | y=12619.3x-1615.8 | 0.9995 | y=12143.2x+122.1 | 0.9995 | |||||||
Flugestone acetate | 4.56-68.38 | 0.09 | 0.27 | y=5428.3x-1096.4 | 0.9990 | y=5306.4x-122.9 | 0.9997 | y=5163.4x+741.7 | 0.9994 | |||||||
21-Hydroxyprogesterone | 5.07-76.05 | 0.10 | 0.30 | y=11451.4x-1698.6 | 0.9982 | y=11308.7x+584.3 | 0.9996 | y=11279.0x-3156.4 | 0.9996 | |||||||
Androstenedione | 5.81-87.21 | 0.12 | 0.35 | y=17471.6x-11903.0 | 0.9981 | y=17552.1x+4557.7 | 0.9983 | y=19174.3x-3611.7 | 0.9993 | |||||||
Ethisterone | 4.38-65.63 | 0.09 | 0.26 | y=18595.7x+1074.9 | 0.9996 | y=18398.4x-2917.6 | 0.9990 | y=19414.3x-4426.9 | 0.9995 | |||||||
Epitestosterone | 4.97-74.61 | 0.10 | 0.30 | y=17060.6x-4118.5 | 0.9998 | y=16327.9x+2126.6 | 0.9995 | y=16835.2x-3733.7 | 0.9995 | |||||||
17-α-Hydroxyprogesterone | 5.33-79.96 | 0.11 | 0.32 | y=6764.9x-6818.1 | 0.9988 | y=6132.2x+739.5 | 0.9990 | y=6182.4x-711.1 | 0.9998 | |||||||
Acenocoumarol | 5.31-79.72 | 0.11 | 0.32 | y=15551.8x-4351.5 | 0.9991 | y=13520.4x-617.9 | 0.9997 | y=14995.2x-4636.0 | 0.9990 | |||||||
Drospirenone | 5.51-82.69 | 0.11 | 0.33 | y=4046.4x+3478.4 | 0.9975 | y=4249.1x+307.1 | 0.9998 | y=3911.0x+3525.2 | 0.9988 | |||||||
Altrenogest | 5.19-77.92 | 0.10 | 0.31 | y=36692.0x+2373.5 | 0.9998 | y=34430.8x+37710.6 | 0.9993 | y=35424.1x+21496.8 | 0.9992 | |||||||
Megestrol | 4.82-72.35 | 0.10 | 0.29 | y=12112.8x+1349.7 | 0.9998 | y=11814.8x+8455.0 | 0.9996 | y=12187.4x+6639.6 | 0.9989 | |||||||
Clostebol | 5.25-78.70 | 0.10 | 0.31 | y=18883.3x-8755.0 | 0.9965 | y=17434.3x+14585.8 | 0.9993 | y=18014.5x+4686.8 | 0.9974 | |||||||
Medroxyprogesterone | 5.07-76.11 | 0.10 | 0.30 | y=20956.2x-9269.3 | 0.9990 | y=19979.6x+124.1 | 0.9998 | y=21791.8x-9387.7 | 0.9984 | |||||||
Dydrogesterone | 4.92-73.87 | 0.10 | 0.30 | y=29437.4x-13658.7 | 0.9988 | y=29802.5x+8945.5 | 0.9992 | y=27343.9x+16116.6 | 0.9990 | |||||||
17-α-Hydroxyprogesterone 17-acetate | 5.44-81.67 | 0.11 | 0.33 | y=32104.7x-11354.8 | 0.9989 | y=29315.2x+22532.3 | 0.9994 | y=29553.4x+12438.3 | 0.9993 | |||||||
Ebastine | 6.35-95.30 | 0.13 | 0.38 | y=95695.6x-5086.0 | 0.9995 | y=91955.3x+20452.1 | 0.9995 | y=93525.4x+100308.0 | 0.9992 | |||||||
Trenbolone-acetate | 5.42-81.37 | 0.11 | 0.33 | y=100624.0x+65911.6 | 0.9977 | y=96363.9x-116855.0 | 0.9986 | y=99984.7x+71205.8 | 0.9988 | |||||||
Phenylbutazone | 16.71-250.60 | 0.33 | 1.00 | y=5567.8x-22493.3 | 0.9997 | y=3986.4x-30865.2 | 0.9961 | y=5291.1x-6485.3 | 0.9969 | |||||||
Isoimperatorin | 13.40-200.97 | 0.27 | 0.80 | y=51475.3x+454144.0 | 0.9986 | y=51420.2x+439348.0 | 0.9962 | y=52292.5x+380312.0 | 0.9981 | |||||||
Norethisterone acetate | 5.60-84.05 | 0.11 | 0.34 | y=14108.6x-10407.8 | 0.9966 | y=12968.4x+4816.3 | 0.9999 | y=13293.7x-2467.3 | 0.9999 | |||||||
Danazol | 6.62-99.32 | 0.13 | 0.40 | y=12354.0x+8239.5 | 0.9990 | y=11759.6x+5276.7 | 0.9992 | y=11555.5x+12133.3 | 0.9988 | |||||||
Pyranocumarin | 4.24-63.56 | 0.08 | 0.25 | y=136375.0x+208747.0 | 0.9988 | y=124269.0x+215334.0 | 0.9970 | y=140515.0x+169625.0 | 0.9997 | |||||||
Testosterone-17-acetate | 5.33-79.93 | 0.11 | 0.32 | y=9767.8x-9500.0 | 0.9992 | y=9348.0x-3651.2 | 0.9995 | y=9229.6x+4154.6 | 0.9996 | |||||||
19-Nortestosterone 17-propionate | 4.88-73.14 | 0.10 | 0.29 | y=21178.0x-19268.7 | 0.9994 | y=17754.7x+7548.0 | 0.9995 | y=22237.4x-3757.6 | 0.9997 | |||||||
Clostebol acetate | 4.70-70.57 | 0.09 | 0.28 | y=7939.0x-205.9 | 0.9995 | y=6830.8x+1177.4 | 0.9985 | y=8361.2x-2815.2 | 0.9958 | |||||||
Testosterone propionate | 5.26-78.96 | 0.11 | 0.32 | y=9055.7x-11374.1 | 0.9981 | y=7838.8x+1484.2 | 0.9999 | y=10164.9x-1759.9 | 0.9999 | |||||||
Nandrolone phenylpropionate | 5.80-86.96 | 0.12 | 0.35 | y=21438.1x-13267.2 | 0.9990 | y=15349.5x+14977.1 | 0.9988 | y=21821.7x+2993.3 | 0.9994 | |||||||
Atranol | 19.23-288.41 | 0.38 | 1.15 | y=4617.4x+38620.6 | 0.9986 | y=4623.1x+58215.1 | 0.9978 | y=4338.6x+53171.1 | 0.9972 | |||||||
Chlorzoxazone | 15.24-228.60 | 0.30 | 0.91 | y=1300.0x+4343.8 | 0.9993 | y=1286.2x+8364.5 | 0.9983 | y=1292.3x+6615.1 | 0.9988 | |||||||
Chloroatranol | 4.80-72.02 | 0.10 | 0.29 | y=6564.3x+714.3 | 0.9995 | y=6277.3x+4689.4 | 0.9995 | y=6182.5x+3986.7 | 0.9986 | |||||||
Dienestrol | 14.81-222.13 | 0.30 | 0.89 | y=299.9x-1737.4 | 0.9962 | y=262.5x+480.6 | 0.9994 | y=284.4x-114.7 | 0.9998 | |||||||
Hexestrol | 16.25-243.81 | 0.33 | 0.98 | y=70.6x-210.1 | 0.9976 | y=64.1x-119.4 | 0.9992 | y=72.7x-463.7 | 0.9983 |
Compound | Toner matrix | Cream matrix | Oil matrix | ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LOQ | 2 LOQ | 10 LOQ | LOQ | 2 LOQ | 10 LOQ | LOQ | 2 LOQ | 10 LOQ | |||||||||||||||||||
Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | ||||||||||
Ranitidine | 108.4 | 4.6 | 97.6 | 3.8 | 96.7 | 4.5 | 106.1 | 6.5 | 96.3 | 4.6 | 99.9 | 3.9 | 102.2 | 6.3 | 93.1 | 5.2 | 99.0 | 1.6 | |||||||||
Sulfacetamide | 95.1 | 3.8 | 91.4 | 2.6 | 84.8 | 2.7 | 88.0 | 4.4 | 88.0 | 1.3 | 88.5 | 1.6 | 92.3 | 3.0 | 97.3 | 4.2 | 95.4 | 0.6 | |||||||||
Dimetridazole | 105.8 | 3.2 | 95.6 | 3.8 | 87.4 | 2.8 | 92.2 | 3.3 | 90.4 | 3.8 | 91.4 | 4.1 | 101.1 | 2.6 | 95.4 | 4.1 | 99.1 | 2.3 | |||||||||
Ronidazole | 104.5 | 2.3 | 99.0 | 3.8 | 91.8 | 1.8 | 92.9 | 2.5 | 98.1 | 3.9 | 94.8 | 0.9 | 90.2 | 4.1 | 98.0 | 3.2 | 99.6 | 1.8 | |||||||||
Sulfadiazine | 101.6 | 2.6 | 107.4 | 7.4 | 99.7 | 2.5 | 96.1 | 4.7 | 107.0 | 2.3 | 104.0 | 1.0 | 85.9 | 3.0 | 101.6 | 4.6 | 102.9 | 2.4 | |||||||||
Emedastine | 101.2 | 5.1 | 111.6 | 2.5 | 104.5 | 3.1 | 87.1 | 5.6 | 91.9 | 6.9 | 104.3 | 4.0 | 104.7 | 7.8 | 109.5 | 4.0 | 98.0 | 7.6 | |||||||||
Doxylamine | 101.0 | 5.2 | 106.4 | 3.9 | 101.4 | 0.8 | 102.0 | 7.2 | 95.7 | 5.0 | 103.0 | 2.0 | 94.1 | 6.1 | 102.9 | 3.2 | 103.7 | 4.0 | |||||||||
Trimethoprim | 93.0 | 3.9 | 100.7 | 2.7 | 97.3 | 3.4 | 87.7 | 3.9 | 98.0 | 2.2 | 98.0 | 3.1 | 88.9 | 5.0 | 99.0 | 2.0 | 103.8 | 2.5 | |||||||||
Marbofloxacin | 105.7 | 7.0 | 111.9 | 2.0 | 98.0 | 4.8 | 91.7 | 8.4 | 98.0 | 6.5 | 109.8 | 3.9 | 84.2 | 4.9 | 112.6 | 8.5 | 95.4 | 5.6 | |||||||||
Tinidazole | 90.2 | 6.1 | 106.8 | 4.5 | 99.4 | 2.7 | 89.1 | 7.5 | 108.7 | 2.8 | 99.2 | 4.0 | 92.0 | 5.8 | 103.1 | 2.9 | 100.2 | 1.6 | |||||||||
Lomefloxacin | 93.7 | 4.8 | 97.7 | 5.5 | 93.3 | 1.2 | 89.8 | 7.5 | 94.1 | 5.2 | 98.6 | 2.6 | 95.0 | 5.5 | 99.2 | 2.2 | 97.4 | 2.5 | |||||||||
Danofloxacin | 92.1 | 4.4 | 112.0 | 5.4 | 97.3 | 3.8 | 105.4 | 4.6 | 102.8 | 6.3 | 113.5 | 3.2 | 92.5 | 5.2 | 110.0 | 4.4 | 97.6 | 8.8 | |||||||||
Methoxyphenamine | 91.9 | 3.8 | 97.0 | 2.8 | 96.0 | 1.5 | 98.2 | 5.4 | 100.7 | 3.1 | 96.7 | 2.4 | 86.9 | 5.3 | 99.3 | 1.9 | 105.6 | 1.6 | |||||||||
Sulfamethazine | 104.0 | 6.6 | 115.4 | 4.1 | 107.7 | 3.3 | 94.3 | 9.1 | 113.4 | 4.3 | 105.6 | 2.2 | 89.6 | 4.1 | 103.4 | 5.2 | 102.9 | 3.0 | |||||||||
Orbifloxacin | 96.0 | 5.1 | 97.4 | 2.6 | 95.8 | 1.9 | 88.6 | 3.6 | 89.8 | 3.7 | 91.8 | 2.4 | 95.2 | 4.9 | 98.6 | 4.2 | 98.7 | 1.0 | |||||||||
Naphazoline | 101.7 | 2.4 | 101.2 | 4.3 | 95.8 | 2.6 | 98.7 | 3.5 | 103.1 | 3.7 | 99.2 | 2.5 | 86.1 | 4.5 | 98.4 | 3.9 | 102.7 | 3.1 | |||||||||
Ornidazole | 100.3 | 6.2 | 97.5 | 4.6 | 93.8 | 2.4 | 94.1 | 3.6 | 95.8 | 3.0 | 94.1 | 1.9 | 102.8 | 2.7 | 98.0 | 3.4 | 94.7 | 2.2 | |||||||||
Gatifloxacin | 101.8 | 6.8 | 98.0 | 4.5 | 97.6 | 1.6 | 99.1 | 5.3 | 98.3 | 3.5 | 98.7 | 3.0 | 92.2 | 5.6 | 96.7 | 4.1 | 96.7 | 2.9 | |||||||||
Sparfloxacin | 94.1 | 8.5 | 94.6 | 3.8 | 88.8 | 5.8 | 82.0 | 7.3 | 86.0 | 5.9 | 91.7 | 6.3 | 105.8 | 3.2 | 101.6 | 6.6 | 95.9 | 4.4 | |||||||||
Methapyrilene | 98.9 | 2.6 | 98.9 | 2.8 | 99.0 | 1.6 | 101.0 | 3.9 | 99.9 | 5.5 | 101.3 | 2.2 | 97.9 | 3.3 | 102.1 | 2.0 | 105.8 | 2.2 | |||||||||
Cinoxacin | 93.2 | 4.1 | 99.0 | 7.1 | 98.9 | 5.6 | 96.0 | 3.8 | 93.7 | 3.3 | 91.7 | 1.4 | 94.8 | 2.1 | 97.8 | 6.8 | 95.5 | 1.1 | |||||||||
Triprolidine | 112.2 | 4.1 | 109.5 | 6.1 | 103.8 | 2.8 | 102.8 | 3.1 | 100.2 | 6.9 | 99.2 | 1.7 | 90.5 | 8.2 | 99.6 | 4.6 | 107.9 | 3.0 | |||||||||
Bromisoval | 102.3 | 4.6 | 95.1 | 5.6 | 94.1 | 2.9 | 86.3 | 3.9 | 92.1 | 3.5 | 98.6 | 4.7 | 98.8 | 5.3 | 94.6 | 4.3 | 99.3 | 1.5 | |||||||||
Xanthotol | 93.5 | 5.9 | 96.1 | 5.1 | 96.6 | 1.9 | 85.3 | 4.9 | 99.0 | 4.5 | 100.3 | 5.6 | 103.5 | 6.1 | 101.5 | 3.0 | 100.6 | 3.0 | |||||||||
Ketotifen | 93.1 | 3.3 | 100.7 | 2.3 | 98.4 | 1.7 | 91.4 | 3.0 | 100.4 | 3.0 | 101.0 | 3.2 | 89.6 | 1.8 | 101.5 | 2.8 | 102.8 | 2.0 | |||||||||
Phenacetin | 94.2 | 5.9 | 107.3 | 1.0 | 96.4 | 1.1 | 90.1 | 2.3 | 99.3 | 3.8 | 94.5 | 1.9 | 90.9 | 2.4 | 102.8 | 2.7 | 98.9 | 2.2 | |||||||||
Oxolinic | 93.9 | 2.6 | 100.7 | 3.8 | 96.3 | 3.2 | 85.2 | 5.2 | 98.7 | 6.8 | 101.7 | 2.5 | 94.9 | 3.2 | 104.1 | 4.5 | 101.2 | 4.4 | |||||||||
Mizolastine | 97.0 | 2.5 | 102.5 | 3.6 | 98.6 | 2.4 | 86.4 | 4.6 | 103.1 | 6.6 | 99.4 | 2.6 | 88.4 | 4.2 | 104.7 | 3.2 | 103.1 | 4.8 | |||||||||
Olopatadine | 103.3 | 1.7 | 98.8 | 4.3 | 92.6 | 5.0 | 90.8 | 2.2 | 93.2 | 5.9 | 95.0 | 5.7 | 101.1 | 5.7 | 99.8 | 3.6 | 98.0 | 4.2 | |||||||||
Decloxizine | 99.6 | 4.2 | 102.8 | 2.5 | 99.8 | 1.1 | 94.6 | 1.8 | 102.9 | 1.7 | 103.4 | 1.7 | 95.0 | 2.2 | 98.8 | 2.4 | 103.0 | 2.1 | |||||||||
Chlomezanone | 111.3 | 2.8 | 102.8 | 3.2 | 96.1 | 3.9 | 103.3 | 2.2 | 101.6 | 4.3 | 101.4 | 2.6 | 99.4 | 6.8 | 90.8 | 8.4 | 103.2 | 2.0 | |||||||||
7-Methoxycoumarin | 107.8 | 6.1 | 101.7 | 5.9 | 92.8 | 4.7 | 95.7 | 5.3 | 93.8 | 4.5 | 91.3 | 3.0 | 88.3 | 6.8 | 94.4 | 6.1 | 98.1 | 3.0 | |||||||||
Carbromal | 103.1 | 5.0 | 99.4 | 2.8 | 96.5 | 1.8 | 88.3 | 5.8 | 94.5 | 0.8 | 98.2 | 2.0 | 101.9 | 3.3 | 103.6 | 2.2 | 105.6 | 3.2 | |||||||||
Acrivastine | 97.4 | 3.5 | 103.9 | 2.1 | 98.1 | 2.1 | 89.7 | 3.6 | 103.3 | 1.5 | 100.8 | 1.6 | 86.2 | 2.1 | 99.9 | 2.8 | 98.3 | 1.4 | |||||||||
Erythromycin | 112.7 | 5.0 | 112.3 | 4.6 | 113.4 | 2.6 | 104.2 | 5.4 | 113.9 | 5.0 | 114.4 | 2.9 | 105.9 | 6.2 | 111.4 | 4.7 | 104.8 | 3.2 | |||||||||
Haloperidol | 100.0 | 3.4 | 107.3 | 3.5 | 100.3 | 1.1 | 93.0 | 5.0 | 101.6 | 5.1 | 102.4 | 4.2 | 87.7 | 4.6 | 99.0 | 4.6 | 104.1 | 2.2 | |||||||||
Nalidixic acid | 95.6 | 5.6 | 102.7 | 4.0 | 97.5 | 3.3 | 92.6 | 6.0 | 106.6 | 2.3 | 102.2 | 3.6 | 92.2 | 2.4 | 104.0 | 5.4 | 101.9 | 4.2 | |||||||||
Xylometazoline | 108.8 | 3.2 | 102.2 | 3.3 | 97.6 | 2.7 | 97.3 | 2.2 | 98.6 | 3.7 | 98.9 | 1.6 | 90.9 | 5.0 | 98.5 | 2.3 | 106.1 | 2.4 | |||||||||
Diphenylpyraline | 96.0 | 1.3 | 99.9 | 3.2 | 97.9 | 1.9 | 96.4 | 3.9 | 100.1 | 2.4 | 100.0 | 3.8 | 99.5 | 5.0 | 100.9 | 2.6 | 100.7 | 3.3 | |||||||||
7-Methylcoumarin | 107.2 | 7.0 | 104.3 | 4.7 | 98.4 | 7.2 | 95.0 | 3.9 | 97.8 | 2.4 | 91.6 | 5.0 | 104.0 | 3.6 | 102.0 | 6.4 | 99.9 | 4.1 | |||||||||
Flumequine | 104.4 | 3.8 | 100.8 | 3.3 | 99.1 | 3.5 | 93.2 | 3.9 | 98.8 | 2.1 | 98.1 | 2.6 | 98.6 | 1.7 | 99.2 | 5.7 | 95.2 | 1.4 | |||||||||
Propyphenazone | 104.3 | 2.5 | 106.3 | 3.7 | 101.0 | 2.7 | 95.6 | 2.8 | 99.7 | 1.4 | 101.7 | 2.3 | 90.2 | 2.2 | 100.7 | 3.3 | 109.1 | 2.7 | |||||||||
Fluoxymesterone | 92.4 | 6.9 | 99.6 | 3.2 | 97.8 | 1.7 | 88.8 | 3.6 | 98.7 | 2.9 | 98.0 | 2.6 | 89.7 | 4.1 | 102.7 | 3.1 | 102.0 | 4.0 | |||||||||
Mifepristone | 105.9 | 3.8 | 108.5 | 3.0 | 101.5 | 5.2 | 92.1 | 4.3 | 102.7 | 5.6 | 102.5 | 4.7 | 95.5 | 5.9 | 106.4 | 5.5 | 108.9 | 2.0 | |||||||||
Adrenosterone | 94.4 | 3.9 | 96.1 | 1.7 | 95.9 | 3.9 | 93.7 | 3.7 | 94.4 | 5.5 | 98.8 | 3.5 | 97.6 | 4.8 | 96.3 | 4.0 | 102.1 | 2.8 | |||||||||
Fexofenadine | 107.6 | 5.1 | 104.7 | 3.3 | 100.0 | 2.2 | 92.9 | 3.7 | 94.2 | 4.5 | 100.6 | 2.4 | 90.2 | 4.3 | 97.3 | 3.6 | 105.4 | 2.4 | |||||||||
Trenbolone | 100.4 | 5.9 | 104.2 | 2.1 | 96.1 | 2.6 | 92.4 | 3.7 | 100.7 | 3.9 | 102.3 | 1.8 | 94.8 | 2.1 | 100.0 | 2.1 | 101.4 | 3.8 | |||||||||
Chlorphenoxamine | 96.0 | 3.1 | 98.7 | 3.0 | 96.8 | 2.7 | 92.2 | 3.2 | 94.1 | 2.6 | 94.3 | 2.1 | 94.7 | 4.2 | 98.8 | 1.1 | 101.9 | 1.9 | |||||||||
Boldenone | 104.5 | 2.3 | 104.4 | 4.0 | 97.5 | 2.0 | 89.6 | 4.1 | 99.8 | 2.4 | 98.7 | 1.2 | 94.9 | 3.4 | 99.8 | 3.6 | 101.2 | 2.0 | |||||||||
Nandrolone | 93.5 | 7.0 | 99.1 | 5.3 | 94.9 | 2.9 | 90.5 | 3.2 | 94.9 | 2.2 | 96.7 | 3.0 | 97.8 | 3.5 | 98.8 | 3.2 | 101.4 | 2.8 | |||||||||
Androstadienedione | 98.0 | 2.8 | 100.8 | 1.7 | 99.0 | 1.8 | 93.5 | 2.4 | 96.7 | 2.4 | 97.9 | 2.2 | 96.6 | 3.2 | 98.9 | 2.8 | 104.2 | 3.0 | |||||||||
7-Ethoxy-4-methylcoumarin | 100.9 | 5.5 | 102.8 | 4.9 | 95.9 | 3.0 | 90.3 | 4.8 | 98.1 | 2.3 | 95.3 | 2.4 | 93.0 | 5.4 | 101.2 | 5.0 | 103.7 | 3.1 | |||||||||
Methandrostenolone | 100.8 | 2.3 | 102.9 | 3.4 | 97.6 | 2.1 | 90.8 | 2.2 | 99.5 | 2.3 | 101.0 | 1.4 | 92.7 | 1.3 | 98.7 | 3.8 | 103.0 | 2.1 | |||||||||
Stanozolol | 107.0 | 3.6 | 105.7 | 3.9 | 103.0 | 3.3 | 91.3 | 4.7 | 98.5 | 4.8 | 99.4 | 2.4 | 99.7 | 2.3 | 100.7 | 3.9 | 103.7 | 3.0 | |||||||||
Terbinafine | 104.7 | 3.0 | 105.2 | 2.3 | 101.3 | 1.7 | 90.9 | 2.6 | 95.4 | 3.5 | 101.4 | 2.7 | 81.7 | 2.3 | 91.3 | 1.6 | 104.6 | 0.7 | |||||||||
Norethisterone | 99.8 | 4.1 | 98.5 | 3.5 | 96.2 | 2.8 | 95.1 | 2.6 | 95.4 | 2.6 | 95.2 | 1.4 | 98.9 | 1.5 | 99.3 | 2.7 | 100.6 | 2.9 | |||||||||
Flugestone acetate | 98.7 | 4.7 | 95.8 | 3.7 | 94.5 | 3.2 | 93.8 | 3.0 | 93.9 | 3.1 | 95.8 | 2.0 | 96.6 | 6.3 | 95.6 | 4.5 | 99.1 | 2.9 | |||||||||
21-Hydroxyprogesterone | 99.1 | 2.7 | 99.8 | 5.2 | 98.2 | 3.4 | 89.2 | 6.1 | 92.4 | 4.2 | 94.9 | 3.6 | 103.1 | 2.1 | 99.1 | 3.7 | 103.9 | 1.0 | |||||||||
Androstenedione | 110.9 | 2.9 | 106.9 | 2.9 | 104.8 | 1.4 | 92.9 | 3.5 | 96.1 | 3.3 | 100.3 | 3.4 | 101.9 | 3.7 | 101.0 | 4.5 | 105.1 | 4.3 | |||||||||
Ethisterone | 101.4 | 9.1 | 104.1 | 4.4 | 101.2 | 4.7 | 87.7 | 4.3 | 91.5 | 4.4 | 97.1 | 1.7 | 102.4 | 4.5 | 100.9 | 4.2 | 103.4 | 3.8 | |||||||||
Epitestosterone | 104.0 | 0.4 | 100.2 | 3.9 | 99.7 | 2.5 | 92.5 | 6.0 | 96.5 | 2.2 | 100.4 | 1.4 | 103.2 | 3.3 | 102.5 | 3.4 | 102.1 | 3.2 | |||||||||
17-α-Hydroxyprogesterone | 109.0 | 2.8 | 100.8 | 4.7 | 93.1 | 2.8 | 90.9 | 5.6 | 96.7 | 3.6 | 98.6 | 4.2 | 101.2 | 4.1 | 94.3 | 4.9 | 100.7 | 2.9 | |||||||||
Acenocoumarol | 106.7 | 3.6 | 100.8 | 7.8 | 97.3 | 3.0 | 96.7 | 6.8 | 96.7 | 5.5 | 104.2 | 6.7 | 98.6 | 6.1 | 96.8 | 4.8 | 98.1 | 5.0 | |||||||||
Drospirenone | 95.3 | 1.8 | 100.4 | 3.5 | 101.2 | 4.3 | 87.4 | 4.1 | 94.4 | 4.0 | 100.1 | 2.3 | 86.7 | 4.3 | 99.6 | 6.4 | 106.8 | 2.2 | |||||||||
Altrenogest | 102.3 | 2.2 | 102.5 | 1.9 | 96.7 | 3.3 | 95.3 | 3.0 | 100.5 | 3.1 | 97.8 | 3.2 | 93.0 | 4.7 | 99.8 | 4.4 | 100.0 | 2.7 | |||||||||
Megestrol | 105.1 | 6.9 | 102.1 | 3.6 | 98.1 | 2.3 | 104.3 | 2.7 | 99.8 | 4.2 | 97.0 | 3.9 | 91.8 | 6.7 | 95.9 | 4.2 | 100.0 | 1.3 | |||||||||
Clostebol | 105.5 | 3.0 | 96.7 | 6.2 | 98.7 | 5.7 | 87.6 | 7.5 | 89.2 | 4.5 | 96.7 | 3.6 | 93.7 | 5.4 | 97.5 | 5.5 | 99.0 | 5.3 | |||||||||
Medroxyprogesterone | 106.0 | 4.9 | 104.3 | 3.4 | 101.7 | 2.8 | 91.8 | 4.1 | 98.5 | 2.2 | 101.3 | 3.0 | 103.0 | 2.8 | 99.2 | 5.0 | 103.8 | 2.9 | |||||||||
Dydrogesterone | 108.0 | 3.9 | 105.5 | 2.6 | 97.2 | 3.8 | 92.3 | 4.3 | 95.8 | 5.3 | 100.0 | 0.4 | 95.5 | 4.2 | 99.2 | 3.0 | 102.2 | 2.6 | |||||||||
17-α-Hydroxyprogesterone 17-acetate | 104.0 | 4.7 | 99.7 | 4.4 | 95.4 | 3.1 | 92.2 | 4.2 | 95.0 | 6.6 | 95.3 | 3.8 | 96.9 | 4.0 | 95.8 | 6.8 | 102.8 | 3.3 | |||||||||
Ebastine | 102.2 | 3.0 | 104.6 | 2.8 | 103.8 | 0.9 | 90.5 | 2.2 | 101.6 | 1.3 | 104.8 | 0.8 | 90.0 | 3.0 | 99.9 | 3.8 | 108.3 | 1.0 | |||||||||
Trenbolone-acetate | 95.6 | 2.5 | 100.9 | 2.3 | 100.0 | 2.4 | 97.5 | 5.0 | 98.1 | 2.6 | 100.5 | 1.5 | 91.0 | 3.5 | 96.6 | 4.1 | 102.5 | 1.7 | |||||||||
Phenylbutazone | 113.1 | 2.8 | 109.1 | 4.2 | 97.2 | 5.2 | 112.5 | 3.6 | 94.6 | 5.9 | 102.9 | 5.1 | 98.8 | 5.8 | 102.5 | 6.5 | 108.3 | 3.5 | |||||||||
Isoimperatorin | 99.4 | 4.5 | 113.0 | 3.4 | 109.0 | 1.6 | 88.4 | 7.7 | 110.8 | 2.6 | 103.2 | 1.3 | 89.8 | 5.7 | 110.6 | 6.1 | 106.6 | 1.1 | |||||||||
Norethisterone acetate | 109.6 | 4.0 | 102.6 | 3.6 | 97.5 | 2.9 | 97.4 | 3.6 | 100.6 | 2.8 | 101.8 | 2.5 | 100.9 | 4.1 | 101.0 | 1.7 | 101.8 | 3.2 | |||||||||
Danazol | 93.7 | 3.5 | 98.2 | 3.5 | 97.0 | 1.5 | 89.3 | 4.2 | 98.3 | 2.7 | 104.2 | 3.8 | 94.4 | 2.9 | 98.7 | 4.8 | 101.8 | 2.5 | |||||||||
Pyranocumarin | 89.5 | 4.5 | 103.3 | 2.2 | 104.1 | 1.8 | 90.4 | 2.5 | 99.3 | 2.3 | 103.5 | 2.9 | 90.1 | 3.0 | 101.2 | 2.9 | 103.8 | 1.6 | |||||||||
Testosterone-17-acetate | 111.2 | 2.9 | 101.7 | 0.5 | 98.8 | 2.6 | 92.2 | 5.3 | 98.4 | 3.5 | 107.2 | 2.1 | 90.0 | 3.1 | 88.7 | 9.9 | 106.7 | 4.4 | |||||||||
19-Nortestosterone 17-propionate | 109.2 | 3.6 | 102.8 | 2.6 | 96.3 | 4.2 | 90.6 | 2.3 | 95.8 | 2.5 | 101.4 | 3.8 | 91.3 | 2.2 | 92.0 | 4.2 | 97.4 | 3.0 | |||||||||
Clostebol acetate | 99.5 | 6.0 | 105.6 | 5.3 | 105.4 | 7.1 | 98.2 | 8.9 | 104.2 | 3.3 | 109.4 | 4.8 | 104.1 | 6.0 | 100.2 | 7.9 | 108.2 | 4.9 | |||||||||
Testosterone propionate | 111.2 | 3.7 | 107.4 | 2.8 | 102.6 | 2.9 | 89.0 | 7.9 | 97.9 | 4.2 | 103.7 | 2.4 | 85.7 | 4.5 | 87.7 | 5.5 | 98.2 | 5.1 | |||||||||
Nandrolone phenylpropionate | 102.5 | 5.7 | 105.6 | 3.1 | 102.2 | 3.2 | 85.4 | 5.4 | 100.7 | 2.1 | 114.9 | 2.4 | 86.8 | 5.2 | 92.7 | 4.4 | 102.3 | 5.7 | |||||||||
Atranol | 99.2 | 3.4 | 110.6 | 3.0 | 99.3 | 0.7 | 91.9 | 1.8 | 110.3 | 2.6 | 101.7 | 2.6 | 84.2 | 4.3 | 106.6 | 3.0 | 102.7 | 1.6 | |||||||||
Chlorzoxazone | 104.9 | 6.3 | 106.4 | 2.6 | 97.4 | 0.8 | 86.4 | 8.2 | 102.6 | 5.1 | 99.6 | 2.6 | 96.6 | 4.8 | 104.7 | 2.4 | 101.7 | 2.2 | |||||||||
Chloroatranol | 104.2 | 7.7 | 101.9 | 3.1 | 99.1 | 1.4 | 86.5 | 7.6 | 97.6 | 3.2 | 102.0 | 2.2 | 94.4 | 6.1 | 99.6 | 7.0 | 102.6 | 2.1 | |||||||||
Dienestrol | 104.1 | 7.6 | 105.9 | 8.5 | 87.4 | 9.0 | 108.1 | 5.7 | 104.2 | 3.0 | 111.7 | 4.1 | 91.5 | 5.0 | 94.8 | 7.7 | 97.3 | 2.5 | |||||||||
Hexestrol | 87.3 | 9.1 | 91.8 | 8.4 | 86.6 | 3.0 | 102.6 | 6.9 | 105.8 | 8.2 | 103.8 | 6.8 | 108.2 | 8.9 | 97.4 | 7.9 | 90.2 | 2.8 |
表3 87种禁用原料在3种化妆品基质中的回收率和相对标准偏差(n=6)
Table 3 Recoveries (Rec.) and relative standard deviations (RSDs)of the 87 prohibited ingredients in three cosmetic matrices (n=6)
Compound | Toner matrix | Cream matrix | Oil matrix | ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LOQ | 2 LOQ | 10 LOQ | LOQ | 2 LOQ | 10 LOQ | LOQ | 2 LOQ | 10 LOQ | |||||||||||||||||||
Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | Rec./% | RSD/% | ||||||||||
Ranitidine | 108.4 | 4.6 | 97.6 | 3.8 | 96.7 | 4.5 | 106.1 | 6.5 | 96.3 | 4.6 | 99.9 | 3.9 | 102.2 | 6.3 | 93.1 | 5.2 | 99.0 | 1.6 | |||||||||
Sulfacetamide | 95.1 | 3.8 | 91.4 | 2.6 | 84.8 | 2.7 | 88.0 | 4.4 | 88.0 | 1.3 | 88.5 | 1.6 | 92.3 | 3.0 | 97.3 | 4.2 | 95.4 | 0.6 | |||||||||
Dimetridazole | 105.8 | 3.2 | 95.6 | 3.8 | 87.4 | 2.8 | 92.2 | 3.3 | 90.4 | 3.8 | 91.4 | 4.1 | 101.1 | 2.6 | 95.4 | 4.1 | 99.1 | 2.3 | |||||||||
Ronidazole | 104.5 | 2.3 | 99.0 | 3.8 | 91.8 | 1.8 | 92.9 | 2.5 | 98.1 | 3.9 | 94.8 | 0.9 | 90.2 | 4.1 | 98.0 | 3.2 | 99.6 | 1.8 | |||||||||
Sulfadiazine | 101.6 | 2.6 | 107.4 | 7.4 | 99.7 | 2.5 | 96.1 | 4.7 | 107.0 | 2.3 | 104.0 | 1.0 | 85.9 | 3.0 | 101.6 | 4.6 | 102.9 | 2.4 | |||||||||
Emedastine | 101.2 | 5.1 | 111.6 | 2.5 | 104.5 | 3.1 | 87.1 | 5.6 | 91.9 | 6.9 | 104.3 | 4.0 | 104.7 | 7.8 | 109.5 | 4.0 | 98.0 | 7.6 | |||||||||
Doxylamine | 101.0 | 5.2 | 106.4 | 3.9 | 101.4 | 0.8 | 102.0 | 7.2 | 95.7 | 5.0 | 103.0 | 2.0 | 94.1 | 6.1 | 102.9 | 3.2 | 103.7 | 4.0 | |||||||||
Trimethoprim | 93.0 | 3.9 | 100.7 | 2.7 | 97.3 | 3.4 | 87.7 | 3.9 | 98.0 | 2.2 | 98.0 | 3.1 | 88.9 | 5.0 | 99.0 | 2.0 | 103.8 | 2.5 | |||||||||
Marbofloxacin | 105.7 | 7.0 | 111.9 | 2.0 | 98.0 | 4.8 | 91.7 | 8.4 | 98.0 | 6.5 | 109.8 | 3.9 | 84.2 | 4.9 | 112.6 | 8.5 | 95.4 | 5.6 | |||||||||
Tinidazole | 90.2 | 6.1 | 106.8 | 4.5 | 99.4 | 2.7 | 89.1 | 7.5 | 108.7 | 2.8 | 99.2 | 4.0 | 92.0 | 5.8 | 103.1 | 2.9 | 100.2 | 1.6 | |||||||||
Lomefloxacin | 93.7 | 4.8 | 97.7 | 5.5 | 93.3 | 1.2 | 89.8 | 7.5 | 94.1 | 5.2 | 98.6 | 2.6 | 95.0 | 5.5 | 99.2 | 2.2 | 97.4 | 2.5 | |||||||||
Danofloxacin | 92.1 | 4.4 | 112.0 | 5.4 | 97.3 | 3.8 | 105.4 | 4.6 | 102.8 | 6.3 | 113.5 | 3.2 | 92.5 | 5.2 | 110.0 | 4.4 | 97.6 | 8.8 | |||||||||
Methoxyphenamine | 91.9 | 3.8 | 97.0 | 2.8 | 96.0 | 1.5 | 98.2 | 5.4 | 100.7 | 3.1 | 96.7 | 2.4 | 86.9 | 5.3 | 99.3 | 1.9 | 105.6 | 1.6 | |||||||||
Sulfamethazine | 104.0 | 6.6 | 115.4 | 4.1 | 107.7 | 3.3 | 94.3 | 9.1 | 113.4 | 4.3 | 105.6 | 2.2 | 89.6 | 4.1 | 103.4 | 5.2 | 102.9 | 3.0 | |||||||||
Orbifloxacin | 96.0 | 5.1 | 97.4 | 2.6 | 95.8 | 1.9 | 88.6 | 3.6 | 89.8 | 3.7 | 91.8 | 2.4 | 95.2 | 4.9 | 98.6 | 4.2 | 98.7 | 1.0 | |||||||||
Naphazoline | 101.7 | 2.4 | 101.2 | 4.3 | 95.8 | 2.6 | 98.7 | 3.5 | 103.1 | 3.7 | 99.2 | 2.5 | 86.1 | 4.5 | 98.4 | 3.9 | 102.7 | 3.1 | |||||||||
Ornidazole | 100.3 | 6.2 | 97.5 | 4.6 | 93.8 | 2.4 | 94.1 | 3.6 | 95.8 | 3.0 | 94.1 | 1.9 | 102.8 | 2.7 | 98.0 | 3.4 | 94.7 | 2.2 | |||||||||
Gatifloxacin | 101.8 | 6.8 | 98.0 | 4.5 | 97.6 | 1.6 | 99.1 | 5.3 | 98.3 | 3.5 | 98.7 | 3.0 | 92.2 | 5.6 | 96.7 | 4.1 | 96.7 | 2.9 | |||||||||
Sparfloxacin | 94.1 | 8.5 | 94.6 | 3.8 | 88.8 | 5.8 | 82.0 | 7.3 | 86.0 | 5.9 | 91.7 | 6.3 | 105.8 | 3.2 | 101.6 | 6.6 | 95.9 | 4.4 | |||||||||
Methapyrilene | 98.9 | 2.6 | 98.9 | 2.8 | 99.0 | 1.6 | 101.0 | 3.9 | 99.9 | 5.5 | 101.3 | 2.2 | 97.9 | 3.3 | 102.1 | 2.0 | 105.8 | 2.2 | |||||||||
Cinoxacin | 93.2 | 4.1 | 99.0 | 7.1 | 98.9 | 5.6 | 96.0 | 3.8 | 93.7 | 3.3 | 91.7 | 1.4 | 94.8 | 2.1 | 97.8 | 6.8 | 95.5 | 1.1 | |||||||||
Triprolidine | 112.2 | 4.1 | 109.5 | 6.1 | 103.8 | 2.8 | 102.8 | 3.1 | 100.2 | 6.9 | 99.2 | 1.7 | 90.5 | 8.2 | 99.6 | 4.6 | 107.9 | 3.0 | |||||||||
Bromisoval | 102.3 | 4.6 | 95.1 | 5.6 | 94.1 | 2.9 | 86.3 | 3.9 | 92.1 | 3.5 | 98.6 | 4.7 | 98.8 | 5.3 | 94.6 | 4.3 | 99.3 | 1.5 | |||||||||
Xanthotol | 93.5 | 5.9 | 96.1 | 5.1 | 96.6 | 1.9 | 85.3 | 4.9 | 99.0 | 4.5 | 100.3 | 5.6 | 103.5 | 6.1 | 101.5 | 3.0 | 100.6 | 3.0 | |||||||||
Ketotifen | 93.1 | 3.3 | 100.7 | 2.3 | 98.4 | 1.7 | 91.4 | 3.0 | 100.4 | 3.0 | 101.0 | 3.2 | 89.6 | 1.8 | 101.5 | 2.8 | 102.8 | 2.0 | |||||||||
Phenacetin | 94.2 | 5.9 | 107.3 | 1.0 | 96.4 | 1.1 | 90.1 | 2.3 | 99.3 | 3.8 | 94.5 | 1.9 | 90.9 | 2.4 | 102.8 | 2.7 | 98.9 | 2.2 | |||||||||
Oxolinic | 93.9 | 2.6 | 100.7 | 3.8 | 96.3 | 3.2 | 85.2 | 5.2 | 98.7 | 6.8 | 101.7 | 2.5 | 94.9 | 3.2 | 104.1 | 4.5 | 101.2 | 4.4 | |||||||||
Mizolastine | 97.0 | 2.5 | 102.5 | 3.6 | 98.6 | 2.4 | 86.4 | 4.6 | 103.1 | 6.6 | 99.4 | 2.6 | 88.4 | 4.2 | 104.7 | 3.2 | 103.1 | 4.8 | |||||||||
Olopatadine | 103.3 | 1.7 | 98.8 | 4.3 | 92.6 | 5.0 | 90.8 | 2.2 | 93.2 | 5.9 | 95.0 | 5.7 | 101.1 | 5.7 | 99.8 | 3.6 | 98.0 | 4.2 | |||||||||
Decloxizine | 99.6 | 4.2 | 102.8 | 2.5 | 99.8 | 1.1 | 94.6 | 1.8 | 102.9 | 1.7 | 103.4 | 1.7 | 95.0 | 2.2 | 98.8 | 2.4 | 103.0 | 2.1 | |||||||||
Chlomezanone | 111.3 | 2.8 | 102.8 | 3.2 | 96.1 | 3.9 | 103.3 | 2.2 | 101.6 | 4.3 | 101.4 | 2.6 | 99.4 | 6.8 | 90.8 | 8.4 | 103.2 | 2.0 | |||||||||
7-Methoxycoumarin | 107.8 | 6.1 | 101.7 | 5.9 | 92.8 | 4.7 | 95.7 | 5.3 | 93.8 | 4.5 | 91.3 | 3.0 | 88.3 | 6.8 | 94.4 | 6.1 | 98.1 | 3.0 | |||||||||
Carbromal | 103.1 | 5.0 | 99.4 | 2.8 | 96.5 | 1.8 | 88.3 | 5.8 | 94.5 | 0.8 | 98.2 | 2.0 | 101.9 | 3.3 | 103.6 | 2.2 | 105.6 | 3.2 | |||||||||
Acrivastine | 97.4 | 3.5 | 103.9 | 2.1 | 98.1 | 2.1 | 89.7 | 3.6 | 103.3 | 1.5 | 100.8 | 1.6 | 86.2 | 2.1 | 99.9 | 2.8 | 98.3 | 1.4 | |||||||||
Erythromycin | 112.7 | 5.0 | 112.3 | 4.6 | 113.4 | 2.6 | 104.2 | 5.4 | 113.9 | 5.0 | 114.4 | 2.9 | 105.9 | 6.2 | 111.4 | 4.7 | 104.8 | 3.2 | |||||||||
Haloperidol | 100.0 | 3.4 | 107.3 | 3.5 | 100.3 | 1.1 | 93.0 | 5.0 | 101.6 | 5.1 | 102.4 | 4.2 | 87.7 | 4.6 | 99.0 | 4.6 | 104.1 | 2.2 | |||||||||
Nalidixic acid | 95.6 | 5.6 | 102.7 | 4.0 | 97.5 | 3.3 | 92.6 | 6.0 | 106.6 | 2.3 | 102.2 | 3.6 | 92.2 | 2.4 | 104.0 | 5.4 | 101.9 | 4.2 | |||||||||
Xylometazoline | 108.8 | 3.2 | 102.2 | 3.3 | 97.6 | 2.7 | 97.3 | 2.2 | 98.6 | 3.7 | 98.9 | 1.6 | 90.9 | 5.0 | 98.5 | 2.3 | 106.1 | 2.4 | |||||||||
Diphenylpyraline | 96.0 | 1.3 | 99.9 | 3.2 | 97.9 | 1.9 | 96.4 | 3.9 | 100.1 | 2.4 | 100.0 | 3.8 | 99.5 | 5.0 | 100.9 | 2.6 | 100.7 | 3.3 | |||||||||
7-Methylcoumarin | 107.2 | 7.0 | 104.3 | 4.7 | 98.4 | 7.2 | 95.0 | 3.9 | 97.8 | 2.4 | 91.6 | 5.0 | 104.0 | 3.6 | 102.0 | 6.4 | 99.9 | 4.1 | |||||||||
Flumequine | 104.4 | 3.8 | 100.8 | 3.3 | 99.1 | 3.5 | 93.2 | 3.9 | 98.8 | 2.1 | 98.1 | 2.6 | 98.6 | 1.7 | 99.2 | 5.7 | 95.2 | 1.4 | |||||||||
Propyphenazone | 104.3 | 2.5 | 106.3 | 3.7 | 101.0 | 2.7 | 95.6 | 2.8 | 99.7 | 1.4 | 101.7 | 2.3 | 90.2 | 2.2 | 100.7 | 3.3 | 109.1 | 2.7 | |||||||||
Fluoxymesterone | 92.4 | 6.9 | 99.6 | 3.2 | 97.8 | 1.7 | 88.8 | 3.6 | 98.7 | 2.9 | 98.0 | 2.6 | 89.7 | 4.1 | 102.7 | 3.1 | 102.0 | 4.0 | |||||||||
Mifepristone | 105.9 | 3.8 | 108.5 | 3.0 | 101.5 | 5.2 | 92.1 | 4.3 | 102.7 | 5.6 | 102.5 | 4.7 | 95.5 | 5.9 | 106.4 | 5.5 | 108.9 | 2.0 | |||||||||
Adrenosterone | 94.4 | 3.9 | 96.1 | 1.7 | 95.9 | 3.9 | 93.7 | 3.7 | 94.4 | 5.5 | 98.8 | 3.5 | 97.6 | 4.8 | 96.3 | 4.0 | 102.1 | 2.8 | |||||||||
Fexofenadine | 107.6 | 5.1 | 104.7 | 3.3 | 100.0 | 2.2 | 92.9 | 3.7 | 94.2 | 4.5 | 100.6 | 2.4 | 90.2 | 4.3 | 97.3 | 3.6 | 105.4 | 2.4 | |||||||||
Trenbolone | 100.4 | 5.9 | 104.2 | 2.1 | 96.1 | 2.6 | 92.4 | 3.7 | 100.7 | 3.9 | 102.3 | 1.8 | 94.8 | 2.1 | 100.0 | 2.1 | 101.4 | 3.8 | |||||||||
Chlorphenoxamine | 96.0 | 3.1 | 98.7 | 3.0 | 96.8 | 2.7 | 92.2 | 3.2 | 94.1 | 2.6 | 94.3 | 2.1 | 94.7 | 4.2 | 98.8 | 1.1 | 101.9 | 1.9 | |||||||||
Boldenone | 104.5 | 2.3 | 104.4 | 4.0 | 97.5 | 2.0 | 89.6 | 4.1 | 99.8 | 2.4 | 98.7 | 1.2 | 94.9 | 3.4 | 99.8 | 3.6 | 101.2 | 2.0 | |||||||||
Nandrolone | 93.5 | 7.0 | 99.1 | 5.3 | 94.9 | 2.9 | 90.5 | 3.2 | 94.9 | 2.2 | 96.7 | 3.0 | 97.8 | 3.5 | 98.8 | 3.2 | 101.4 | 2.8 | |||||||||
Androstadienedione | 98.0 | 2.8 | 100.8 | 1.7 | 99.0 | 1.8 | 93.5 | 2.4 | 96.7 | 2.4 | 97.9 | 2.2 | 96.6 | 3.2 | 98.9 | 2.8 | 104.2 | 3.0 | |||||||||
7-Ethoxy-4-methylcoumarin | 100.9 | 5.5 | 102.8 | 4.9 | 95.9 | 3.0 | 90.3 | 4.8 | 98.1 | 2.3 | 95.3 | 2.4 | 93.0 | 5.4 | 101.2 | 5.0 | 103.7 | 3.1 | |||||||||
Methandrostenolone | 100.8 | 2.3 | 102.9 | 3.4 | 97.6 | 2.1 | 90.8 | 2.2 | 99.5 | 2.3 | 101.0 | 1.4 | 92.7 | 1.3 | 98.7 | 3.8 | 103.0 | 2.1 | |||||||||
Stanozolol | 107.0 | 3.6 | 105.7 | 3.9 | 103.0 | 3.3 | 91.3 | 4.7 | 98.5 | 4.8 | 99.4 | 2.4 | 99.7 | 2.3 | 100.7 | 3.9 | 103.7 | 3.0 | |||||||||
Terbinafine | 104.7 | 3.0 | 105.2 | 2.3 | 101.3 | 1.7 | 90.9 | 2.6 | 95.4 | 3.5 | 101.4 | 2.7 | 81.7 | 2.3 | 91.3 | 1.6 | 104.6 | 0.7 | |||||||||
Norethisterone | 99.8 | 4.1 | 98.5 | 3.5 | 96.2 | 2.8 | 95.1 | 2.6 | 95.4 | 2.6 | 95.2 | 1.4 | 98.9 | 1.5 | 99.3 | 2.7 | 100.6 | 2.9 | |||||||||
Flugestone acetate | 98.7 | 4.7 | 95.8 | 3.7 | 94.5 | 3.2 | 93.8 | 3.0 | 93.9 | 3.1 | 95.8 | 2.0 | 96.6 | 6.3 | 95.6 | 4.5 | 99.1 | 2.9 | |||||||||
21-Hydroxyprogesterone | 99.1 | 2.7 | 99.8 | 5.2 | 98.2 | 3.4 | 89.2 | 6.1 | 92.4 | 4.2 | 94.9 | 3.6 | 103.1 | 2.1 | 99.1 | 3.7 | 103.9 | 1.0 | |||||||||
Androstenedione | 110.9 | 2.9 | 106.9 | 2.9 | 104.8 | 1.4 | 92.9 | 3.5 | 96.1 | 3.3 | 100.3 | 3.4 | 101.9 | 3.7 | 101.0 | 4.5 | 105.1 | 4.3 | |||||||||
Ethisterone | 101.4 | 9.1 | 104.1 | 4.4 | 101.2 | 4.7 | 87.7 | 4.3 | 91.5 | 4.4 | 97.1 | 1.7 | 102.4 | 4.5 | 100.9 | 4.2 | 103.4 | 3.8 | |||||||||
Epitestosterone | 104.0 | 0.4 | 100.2 | 3.9 | 99.7 | 2.5 | 92.5 | 6.0 | 96.5 | 2.2 | 100.4 | 1.4 | 103.2 | 3.3 | 102.5 | 3.4 | 102.1 | 3.2 | |||||||||
17-α-Hydroxyprogesterone | 109.0 | 2.8 | 100.8 | 4.7 | 93.1 | 2.8 | 90.9 | 5.6 | 96.7 | 3.6 | 98.6 | 4.2 | 101.2 | 4.1 | 94.3 | 4.9 | 100.7 | 2.9 | |||||||||
Acenocoumarol | 106.7 | 3.6 | 100.8 | 7.8 | 97.3 | 3.0 | 96.7 | 6.8 | 96.7 | 5.5 | 104.2 | 6.7 | 98.6 | 6.1 | 96.8 | 4.8 | 98.1 | 5.0 | |||||||||
Drospirenone | 95.3 | 1.8 | 100.4 | 3.5 | 101.2 | 4.3 | 87.4 | 4.1 | 94.4 | 4.0 | 100.1 | 2.3 | 86.7 | 4.3 | 99.6 | 6.4 | 106.8 | 2.2 | |||||||||
Altrenogest | 102.3 | 2.2 | 102.5 | 1.9 | 96.7 | 3.3 | 95.3 | 3.0 | 100.5 | 3.1 | 97.8 | 3.2 | 93.0 | 4.7 | 99.8 | 4.4 | 100.0 | 2.7 | |||||||||
Megestrol | 105.1 | 6.9 | 102.1 | 3.6 | 98.1 | 2.3 | 104.3 | 2.7 | 99.8 | 4.2 | 97.0 | 3.9 | 91.8 | 6.7 | 95.9 | 4.2 | 100.0 | 1.3 | |||||||||
Clostebol | 105.5 | 3.0 | 96.7 | 6.2 | 98.7 | 5.7 | 87.6 | 7.5 | 89.2 | 4.5 | 96.7 | 3.6 | 93.7 | 5.4 | 97.5 | 5.5 | 99.0 | 5.3 | |||||||||
Medroxyprogesterone | 106.0 | 4.9 | 104.3 | 3.4 | 101.7 | 2.8 | 91.8 | 4.1 | 98.5 | 2.2 | 101.3 | 3.0 | 103.0 | 2.8 | 99.2 | 5.0 | 103.8 | 2.9 | |||||||||
Dydrogesterone | 108.0 | 3.9 | 105.5 | 2.6 | 97.2 | 3.8 | 92.3 | 4.3 | 95.8 | 5.3 | 100.0 | 0.4 | 95.5 | 4.2 | 99.2 | 3.0 | 102.2 | 2.6 | |||||||||
17-α-Hydroxyprogesterone 17-acetate | 104.0 | 4.7 | 99.7 | 4.4 | 95.4 | 3.1 | 92.2 | 4.2 | 95.0 | 6.6 | 95.3 | 3.8 | 96.9 | 4.0 | 95.8 | 6.8 | 102.8 | 3.3 | |||||||||
Ebastine | 102.2 | 3.0 | 104.6 | 2.8 | 103.8 | 0.9 | 90.5 | 2.2 | 101.6 | 1.3 | 104.8 | 0.8 | 90.0 | 3.0 | 99.9 | 3.8 | 108.3 | 1.0 | |||||||||
Trenbolone-acetate | 95.6 | 2.5 | 100.9 | 2.3 | 100.0 | 2.4 | 97.5 | 5.0 | 98.1 | 2.6 | 100.5 | 1.5 | 91.0 | 3.5 | 96.6 | 4.1 | 102.5 | 1.7 | |||||||||
Phenylbutazone | 113.1 | 2.8 | 109.1 | 4.2 | 97.2 | 5.2 | 112.5 | 3.6 | 94.6 | 5.9 | 102.9 | 5.1 | 98.8 | 5.8 | 102.5 | 6.5 | 108.3 | 3.5 | |||||||||
Isoimperatorin | 99.4 | 4.5 | 113.0 | 3.4 | 109.0 | 1.6 | 88.4 | 7.7 | 110.8 | 2.6 | 103.2 | 1.3 | 89.8 | 5.7 | 110.6 | 6.1 | 106.6 | 1.1 | |||||||||
Norethisterone acetate | 109.6 | 4.0 | 102.6 | 3.6 | 97.5 | 2.9 | 97.4 | 3.6 | 100.6 | 2.8 | 101.8 | 2.5 | 100.9 | 4.1 | 101.0 | 1.7 | 101.8 | 3.2 | |||||||||
Danazol | 93.7 | 3.5 | 98.2 | 3.5 | 97.0 | 1.5 | 89.3 | 4.2 | 98.3 | 2.7 | 104.2 | 3.8 | 94.4 | 2.9 | 98.7 | 4.8 | 101.8 | 2.5 | |||||||||
Pyranocumarin | 89.5 | 4.5 | 103.3 | 2.2 | 104.1 | 1.8 | 90.4 | 2.5 | 99.3 | 2.3 | 103.5 | 2.9 | 90.1 | 3.0 | 101.2 | 2.9 | 103.8 | 1.6 | |||||||||
Testosterone-17-acetate | 111.2 | 2.9 | 101.7 | 0.5 | 98.8 | 2.6 | 92.2 | 5.3 | 98.4 | 3.5 | 107.2 | 2.1 | 90.0 | 3.1 | 88.7 | 9.9 | 106.7 | 4.4 | |||||||||
19-Nortestosterone 17-propionate | 109.2 | 3.6 | 102.8 | 2.6 | 96.3 | 4.2 | 90.6 | 2.3 | 95.8 | 2.5 | 101.4 | 3.8 | 91.3 | 2.2 | 92.0 | 4.2 | 97.4 | 3.0 | |||||||||
Clostebol acetate | 99.5 | 6.0 | 105.6 | 5.3 | 105.4 | 7.1 | 98.2 | 8.9 | 104.2 | 3.3 | 109.4 | 4.8 | 104.1 | 6.0 | 100.2 | 7.9 | 108.2 | 4.9 | |||||||||
Testosterone propionate | 111.2 | 3.7 | 107.4 | 2.8 | 102.6 | 2.9 | 89.0 | 7.9 | 97.9 | 4.2 | 103.7 | 2.4 | 85.7 | 4.5 | 87.7 | 5.5 | 98.2 | 5.1 | |||||||||
Nandrolone phenylpropionate | 102.5 | 5.7 | 105.6 | 3.1 | 102.2 | 3.2 | 85.4 | 5.4 | 100.7 | 2.1 | 114.9 | 2.4 | 86.8 | 5.2 | 92.7 | 4.4 | 102.3 | 5.7 | |||||||||
Atranol | 99.2 | 3.4 | 110.6 | 3.0 | 99.3 | 0.7 | 91.9 | 1.8 | 110.3 | 2.6 | 101.7 | 2.6 | 84.2 | 4.3 | 106.6 | 3.0 | 102.7 | 1.6 | |||||||||
Chlorzoxazone | 104.9 | 6.3 | 106.4 | 2.6 | 97.4 | 0.8 | 86.4 | 8.2 | 102.6 | 5.1 | 99.6 | 2.6 | 96.6 | 4.8 | 104.7 | 2.4 | 101.7 | 2.2 | |||||||||
Chloroatranol | 104.2 | 7.7 | 101.9 | 3.1 | 99.1 | 1.4 | 86.5 | 7.6 | 97.6 | 3.2 | 102.0 | 2.2 | 94.4 | 6.1 | 99.6 | 7.0 | 102.6 | 2.1 | |||||||||
Dienestrol | 104.1 | 7.6 | 105.9 | 8.5 | 87.4 | 9.0 | 108.1 | 5.7 | 104.2 | 3.0 | 111.7 | 4.1 | 91.5 | 5.0 | 94.8 | 7.7 | 97.3 | 2.5 | |||||||||
Hexestrol | 87.3 | 9.1 | 91.8 | 8.4 | 86.6 | 3.0 | 102.6 | 6.9 | 105.8 | 8.2 | 103.8 | 6.8 | 108.2 | 8.9 | 97.4 | 7.9 | 90.2 | 2.8 |
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