Separation, enrichment, mass spectrometric quantification and evaluation of serum phosphopeptides as potential tumor biomarkers

doi:10.3724/SP.J.1123.2016.08037

Abstract

Abstract:

Serum phosphopeptides has been a vital objective for the discovery of tumor biomarkers as their levels can reflect the changes in the activities of both endo-and exo-proteases, and the level of protein phosphorylation. Comprehensive analysis of serum phosphopeptides may lead to discovery of novel tumor biomarkers for clinical diagnosis. However, the extremely low abundance of serum phosphopeptides as well as high background level of highly abundant non-phosphoproteins/peptides makes the mass spectrometry (MS)-based phosphopeptide profiling a great challenge. In this review, we will summarize and review update advances in the separation, enrichment and MS quantification of phosphopeptides as well as the evaluation of serum phosphopeptides as potential tumor biomarkers. We will also prospect the future tendency and applications of this multi-disciplinary research field.

Key words: mass spectrometric quantification, phosphopeptides, review, separation and enrichment, serum, tumor biomarkers

CLC Number:

O658

ZHAI Guijin, WU Kui, WANG Fuyi. Separation, enrichment, mass spectrometric quantification and evaluation of serum phosphopeptides as potential tumor biomarkers[J]. Chinese Journal of Chromatography, 2016, 34(12): 1192-1198.

References

[1] Hunter T. Cell, 2000, 100:113
[2] Paradela A, Albar J P. J Proteome Res, 2008, 7:1809
[3] Reinders J, Sickmann A. Proteomics, 2005, 5:4052
[4] Thingholm T E, Jensen O N, Larsen M R. Proteomics, 2009, 9:1451
[5] Zanivan S, Meves A, Behrendt K, et al. Cell Rep, 2013, 3:552
[6] Zhang Y Y, Fonslow B R, Shan B, et al. Chem Rev, 2013, 113:2343
[7] He K, Wen X Y, Li A L, et al. PLoS One, 2013, 8:e63724
[8] Villanueva J, Martorella A J, Lawlor K, et al. Mol Cell Proteomics, 2006, 5:1840
[9] Liotta L A, Petricoin E F. J Clin Invest, 2006, 116:26
[10] Lee H J, Na K, Kwon M S, et al. Proteomics, 2009, 9:3395
[11] Jensen O N. Nat Rev Mol Cell Bio, 2006, 7:391
[12] Zhou W D, Ross M M, Tessitore A, et al. J Proteome Res, 2009, 8:5523
[13] Ficarro S B, McCleland M L, Stukenberg P T, et al. Nat Biotechnol, 2002, 20:301
[14] Lu Z D, Duan J C, He L, et al. Anal Chem, 2010, 82:7249
[15] Zou Y, Jiang W H, Zou L J, et al. Chinese Journal of Chromatography, 2013, 31(4):367 邹瑶, 姜武辉, 邹丽娟, 等. 色谱, 2013, 31(4):367
[16] Anderson N L, Anderson N G. Mol Cell Proteomics, 2002, 1:845
[17] Oda Y, Nagasu T, Chait B T. Nat Biotechnol, 2001, 19:379
[18] Lin H Z, Deng C H. Talanta, 2016, 149:91
[19] Zhou H J, Ye M L, Dong J, et al. J Proteome Res, 2008, 7:3957
[20] Li X S, Yuan B F, Feng Y Q. TrAC-Trends Anal Chem, 2016, 78:70
[21] Posewitz M C, Tempst P. Anal Chem, 1999, 71:2883
[22] Trojer L, Stecher G, Feuerstein I, et al. J Chromatogr A, 2005, 1079:197
[23] Zhao Y Y, Guo Z M, Li X L, et al. Chinese Journal of Chromatography, 2013, 31(8):763 赵艳艳, 郭志谋, 李秀玲, 等. 色谱, 2013, 31(8):763
[24] Kokubu M, Ishihama Y, Sato T, et al. Anal Chem, 2005, 77:5144
[25] Cirulli C, Chiappetta G, Marino G, et al. Anal Bioanal Chem, 2008, 392:147
[26] Li Y, Lin H Q, Deng C H, et al. Proteomics, 2008, 8:238
[27] Li X S, Pan Y N, Zhao Y, et al. J Chromatogr A, 2013, 1315:61
[28] Zhou H J, Xu S Y, Ye M L, et al. J Proteome Res, 2006, 5:2431
[29] Feng S, Ye M L, Zhou H J, et al. Mol Cell Proteomics, 2007, 6:1656
[30] Yu Z Y, Han G H, Sun S T, et al. Anal Chim Acta, 2009, 636:34
[31] Zhou H J, Ye M L, Dong J, et al. Nat Protoc, 2013, 8:461
[32] Li X S, Xu L D, Zhu G T, et al. Analyst, 2012, 137:959
[33] Zhu J, Wang F J, Cheng K, et al. J Proteomics, 2013, 78:389
[34] Hu L H, Zhou H J, Li Y H, et al. Anal Chem, 2009, 81:94
[35] Ji L Y, Wu J H, Luo Q, et al. Anal Chem, 2012, 84:2284
[36] Kweon H K, Hakansson K. Anal Chem, 2006, 78:1743
[37] Wu J H, Li X S, Zhao Y, et al. Chem Commun, 2010, 46:9031
[38] Min Q H, Zhang X X, Zhang H Y, et al. Chem Commun, 2011, 47:11709
[39] Lin B, Li T, Zhao Y, et al. J Chromatogr A, 2008, 1192:95
[40] Lu S, Luo Q, Li X C, et al. Analyst, 2010, 135:2858
[41] Liu H L, Yang T Y, Dai J Y, et al. Analyst, 2015, 140:6652
[42] Yao J, Sun N, Deng C, et al. Talanta, 2016, 150:296
[43] Zhu G T, He X M, Chen X, et al. J Chromatogr A, 2016, 1437:137
[44] Lu Z D, Ye M M, Li N, et al. Angew Chem Int Edit, 2010, 49:1862
[45] Ong S E, Blagoev B, Kratchmarova I, et al. Mol Cell Proteomics, 2002, 1:376
[46] Gygi S P, Rist B, Gerber S A, et al. Nat Biotechnol, 1999, 17:994
[47] Ross P L, Huang Y L N, Marchese J N, et al. Mol Cell Proteomics, 2004, 3:1154
[48] Thompson A, Schafer J, Kuhn K, et al. Anal Chem, 2003, 75:1895
[49] Boersema P J, Foong L Y, Ding V M Y, et al. Mol Cell Proteomics, 2010, 9:84
[50] Hsu J L, Huang S Y, Chow N H, et al. Anal Chem, 2003, 75:6843
[51] Wu C J, Chen Y W, Tai J H, et al. J Proteome Res, 2011, 10:1088
[52] Chen X Q, Li S Y, Zhang X X, et al. Nanoscale, 2015, 7:5815
[53] Chakraborty A, Regnier F E. J Chromatogr A, 2002, 949:173
[54] Ji J Y, Chakraborty A, Geng M, et al. J Chromatogr B, 2000, 745:197
[55] Zhang R J, Sioma C S, Wang S H, et al. Anal Chem, 2001, 73:5142
[56] Kindy J M, Taraszka J A, Regnier F E, et al. Anal Chem, 2002, 74:950
[57] Xun Z Y, Sowell R A, Kaufman T C, et al. Mol Cell Proteomics, 2008, 7:1191
[58] Du Z F, Luo Q, Yang L P, et al. J Am Chem Soc, 2014, 136:2948
[59] Zhai G J, Wu X Y, Luo Q, et al. Talanta, 2014, 125:411
[60] Gerber S A, Rush J, Stemman O, et al. P Natl Acad Sci USA, 2003, 100:6940
[61] Zhang X W, Li L, Wei D, et al. Trends Biotechnol, 2007, 25:166
[62] Diamandis E P. J Natl Cancer I, 2010, 102:1462
[63] Qin H Q, Wang F J, Wang P Y, et al. Chem Commun, 2012, 48:961
[64] Min Q H, Chen X Q, Zhang X X, et al. Lab Chip, 2013, 13:3853