Preparation and application of magnetic reversed-phase restricted access material

doi:10.3724/SP.J.1123.2018.01040

Abstract

Abstract:

Using magnetic silica (Fe₂O₃@SiO₂) as the matrix material, a magnetic reversed-phase restricted access material was prepared via surface-initiation atom transfer radical polymerization (SI-ATRP) on the surface of modified Fe₂O₃@SiO₂. Stearyl methacrylate (SMA) was grafted on the inner surface of the modified Fe₂O₃@SiO₂, and glycidylmethacrylate (GMA) was grafted on the outer surface of the modified Fe₂O₃@SiO₂. The magnetic reversed-phase restricted access material was prepared via acid hydrolysis. This material was characterized by scanning electron microscope (SEM), X-ray diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM) and elemental analysis. The exclusion ability of the opened magnetic reversed-phase restricted access material to bovine serum albumin (BSA) was 90.4%. The maximum adsorbed amounts of sulfisoxazole (SIZ), sulfadimethoxine (SDM), trimethoprim (TMP) and sulfamerazine (SMR) were 2.76, 2.24, 1.51 and 1.34 mg/g, respectively. This material was applied to extract and enrich SIZ, SMR and SDM in milk and bovine serum samples. The spiked recoveries of SIZ, SMR and SDM were 88.7%-90.8%, and the relative standard deviations were 3.3%-5.3%. Thus, the magnetic phase restricted access material can simplify the pretreatment of biological matrix samples, and can be applied to the analysis and detection of blood samples or food samples.

Key words: magnetic reversed-phase restricted access material, preparation, solid phase extraction(SPE), sulfonamides(SAs), surface-initiated atom transfer radical polymerization(SI-ATRP)

CLC Number:

O658

WU Shanshan, WEI Chanling, ZHAO Lijuan, TIAN Yang, WANG Fuqiang, GONG Bolin. Preparation and application of magnetic reversed-phase restricted access material[J]. Chinese Journal of Chromatography, 2018, 36(7): 608-614.

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