Chinese Journal of Chromatography

Chinese Journal of Chromatography ›› 2018, Vol. 36 ›› Issue (7): 634-642.DOI: 10.3724/SP.J.1123.2018.01047

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Rapid determination of 48 contaminant residues in food contact plastic products by ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry coupled with microwave-assisted extraction

ZHANG Xianchen1, ZHANG Pengjie1, SHI Chengyu1, HUA Hongbo2, RONG Yutang1, LU Junwen1, YANG Fang1   

  1. 1. Inspection and Quarantine Technology Center of Zhongshan Entry-Exit Inspection and Quarantine Bureau, Zhongshan 528403, China;
    2. Zhongshan Zhuoya Foreign Language School, Zhongshan 528401, China
  • Received:2018-01-30 Online:2018-07-08 Published:2014-06-03
  • Supported by:

    Science and Technology Plan Project of General Administration of Quality Supervision Inspection and Quarantine(AQSIQ) of China(No. 2015IK052);Social Public Welfare Project of Zhongshan City(No. 2017B1029);Science and Technology Plan Project of Entry-Exit Inspection and Quarantine Bureau of Guangdong(No. 2017GDK24).

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Abstract:

An ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry (UPLC-Q Orbitrap HRMS) method was developed for the rapid determination of 48 contaminant residues in food plastic packaging materials. The samples were extracted with methanol using microwave-assisted extraction. The separation of the 48 contaminants was performed on a CAPCELL PAK MG Ⅱ C18 column (150 mm×2.0 mm, 5 μm) with gradient elution. Methanol (containing 0.04% (v/v) formic acid) and water (containing 0.04% (v/v) formic acid and 20 mmol/L ammonium acetate) were used as mobile phases. The compounds were detected under the full scan/date dependent-MS/MS (Full MS/dd-MS2) mode with a heated electrospray ionization (HESI) source. The calibration curves were linear with correlation coefficients no less than 0.9950. The limits of detection (LODs) ranged from 0.1 to 1.0 μg/kg. The average spiked recoveries of the 48 target compounds were between 71.2% and 108.8%, with relative standard derivations (RSDs) ranging from 2.2% to 11.8% (n=6). Compared to previous methods, this method has advantages of simpler sample preparation and higher sensitivity.

Key words: contaminants, food contact plastic products, microwave-assisted extraction, quadrupole/electrostatic field orbitrap high resolution mass spectrometry(Q Orbitrap HRMS), ultra performance liquid chromatography(UPLC)

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