Simultaneous determination of five types of 40 antibiotics in surface water using high performance liquid chromatography-tandem mass spectrometry

doi:10.3724/SP.J.1123.2018.11016

Abstract

Abstract:

A method was developed for the determination of five categories of 40 antibiotics in surface water by using solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry (SPE-HPLC-MS/MS). The water samples were enriched and cleaned-up by filtration and with SPE cartridges. All antibiotics were separated by gradient elution with the mobile phase of 0.2% (v/v) formic acid aqueous solution and acetonitrile, and then analyzed with an electrospray ionization source in the positive ion and multiple reaction monitoring (MRM) modes. The results showed that the 40 antibiotics achieved great linearity in the range of 1-200 μg/L, and the average recoveries ranged from 41.3% to 112.6%. Using the developed method, thirteen antibiotics were identified in surface water from Nanjing section of the Yangtze River. The total antibiotic contents in the real samples ranged from 13.4 ng/L to 780.5 ng/L. The established method is efficient, sensitive and reliable, and is suitable for the determination of different antibiotics in real water samples.

Key words: antibiotics, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), solid phase extraction (SPE), surface water

CLC Number:

O658

FENG Mengjuan, YANG Zhengbiao, ZHANG Qin, SONG Ninghui, LIU Yanhua, GUO Ruixin, CHEN Jianqiu, ZHANG Shenghu. Simultaneous determination of five types of 40 antibiotics in surface water using high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2019, 37(5): 525-532.

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