Recent advances of separation and analysis of chiral compounds by capillary electrophoresis

doi:10.3724/SP.J.1123.2019.10019

Abstract

Abstract:

As the enantiomers of chiral compounds often exhibit different physiological activities, the establishment of effective separation and analytical methods for chiral compounds is of great significance. As a widely used chiral separation and detection technique, capillary electrophoresis (CE) offers the advantages of high separation efficiency, high speed, small sample consumption and flexible separation mode. In this review, research progresses in chiral separation by CE for the period 2017 to 2019 are summarized, and future developments are prospected.

Key words: capillary electrophoresis (CE), chiral separation, review

LIU Mingxia, LI Xiangjun, BAI Yu, LIU Huwei. Recent advances of separation and analysis of chiral compounds by capillary electrophoresis[J]. Chinese Journal of Chromatography, 2020, 38(3): 317-323.

Figures/Tables 2

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Chiral selectors	Chiral ionic liquids	Analytes	Ref.
α-CD: α-cyclodextrin; HP-β-CD: hydroxypropyl-β-cyclodextrin.
α-CD	tetramethylammonium-L-arginine, tetraethylammonium-L-arginine, tetrabutylammonium-L-arginine, tetramethylammonium-L-proline, tetramethylammonium-L-glutamic acid, tetramethylammonium hydroxide	amlodipine, citalopram, nefopam, sulconazole, tryptophan	[22]
β-CD	tetramethylammonium-L-arginine	dansyl-tryptophan, dansyl-phenylalanine, dansyl-tyrosine, dansyl-histidine, dansyl-cysteine, dansyl-alanine	[28]
HP-β-CD	N, N, N-trimethyl-L-valinol-bis(trifluoromethanesulfon)imide, N, N-dimethyl-L-prolinol-bis(trifluoromethanesulfon)imide, N, N, N-trimethyl-L-phenylalaninol-bis(trifluoromethanesulfon)imide	laudanosine, nefopam, ketoconazole, amlodipine, sulconazole, econazole	[21]
HP-β-CD	tetramethylammonium-L-lysine, tetramethylammonium L-glutamic acid, tetrabutylammonium L-lysine, tetrabutylammonium L-glutamic acid	duloxetine, verapamil, terbutaline, econazole, sulconazole, metoprolol, nadolol	[29]
Trimethyl-β-CD, HP-β-CD	L-alanine tert butyl ester lactate	warfarin, coumachlor	[30]
γ-CD	R-N, N, N-trimethyl-2-aminobutanol-bis(trifluoromethane-sulfon)imidate	9-fluorenylmethoxycarbonyl-homocysteine	[23, 31]
Sulfated-γ-CD	tetrabutylammonium-L-aspartic acid	ivabradine	[32]
Clindamycin phosphate	tetramethylammonium-lactobionate	propranolol, nefopam, citalopram, chlorphenamine, metoprolol, bisoprolol, esmolol	[24]
Dextrin	1-butyl-3-methylimidazolium(T-4)-bis[(2S)-2-(hydroxy-κO)-3-methyl-butanoato-κO]borate, 1-butyl-3-methylimidazolium(T-4)-bis[(αS)-α-(hydroxy-κO)-4-methyl-benzeneacetato-κO]borate	duloxetine, ketoconazole, sulconazole, citalopram	[25]
Maltodextrin	tertramethylammonium-D-pantothenate, tertramethylammonium-D-quinate	nefopan, ketoconazole, econazole, voriconazole	[26]
Maltodextrin	tetramethylammonium-L-arginine	nefopam, duloxetine, ketoconazole, cetirizine, citalopram	[27]
Cyclofructan-6	L-alanine tert butyl ester lactate	fexofenadine, nefopam	[30]

Chiral selectors	Chiral ionic liquids	Analytes	Ref.
α-CD: α-cyclodextrin; HP-β-CD: hydroxypropyl-β-cyclodextrin.
α-CD	tetramethylammonium-L-arginine, tetraethylammonium-L-arginine, tetrabutylammonium-L-arginine, tetramethylammonium-L-proline, tetramethylammonium-L-glutamic acid, tetramethylammonium hydroxide	amlodipine, citalopram, nefopam, sulconazole, tryptophan	[22]
β-CD	tetramethylammonium-L-arginine	dansyl-tryptophan, dansyl-phenylalanine, dansyl-tyrosine, dansyl-histidine, dansyl-cysteine, dansyl-alanine	[28]
HP-β-CD	N, N, N-trimethyl-L-valinol-bis(trifluoromethanesulfon)imide, N, N-dimethyl-L-prolinol-bis(trifluoromethanesulfon)imide, N, N, N-trimethyl-L-phenylalaninol-bis(trifluoromethanesulfon)imide	laudanosine, nefopam, ketoconazole, amlodipine, sulconazole, econazole	[21]
HP-β-CD	tetramethylammonium-L-lysine, tetramethylammonium L-glutamic acid, tetrabutylammonium L-lysine, tetrabutylammonium L-glutamic acid	duloxetine, verapamil, terbutaline, econazole, sulconazole, metoprolol, nadolol	[29]
Trimethyl-β-CD, HP-β-CD	L-alanine tert butyl ester lactate	warfarin, coumachlor	[30]
γ-CD	R-N, N, N-trimethyl-2-aminobutanol-bis(trifluoromethane-sulfon)imidate	9-fluorenylmethoxycarbonyl-homocysteine	[23, 31]
Sulfated-γ-CD	tetrabutylammonium-L-aspartic acid	ivabradine	[32]
Clindamycin phosphate	tetramethylammonium-lactobionate	propranolol, nefopam, citalopram, chlorphenamine, metoprolol, bisoprolol, esmolol	[24]
Dextrin	1-butyl-3-methylimidazolium(T-4)-bis[(2S)-2-(hydroxy-κO)-3-methyl-butanoato-κO]borate, 1-butyl-3-methylimidazolium(T-4)-bis[(αS)-α-(hydroxy-κO)-4-methyl-benzeneacetato-κO]borate	duloxetine, ketoconazole, sulconazole, citalopram	[25]
Maltodextrin	tertramethylammonium-D-pantothenate, tertramethylammonium-D-quinate	nefopan, ketoconazole, econazole, voriconazole	[26]
Maltodextrin	tetramethylammonium-L-arginine	nefopam, duloxetine, ketoconazole, cetirizine, citalopram	[27]
Cyclofructan-6	L-alanine tert butyl ester lactate	fexofenadine, nefopam	[30]

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