Advances in dispersive liquid-liquid microextraction and its application to analysis of biological samples

doi:10.3724/SP.J.1123.2019.10026

Abstract

Abstract:

Dispersive liquid-liquid microextraction (DLLME) is a mini-extraction technology with merits of low cost, environment friendliness, and high extraction efficiency; moreover, this method is easy to operate and requires only a short operation time. In this paper, several extraction models, including normal dispersive liquid-liquid microextraction, ionic liquid dispersive liquid-liquid microextraction, and ultrasound-assisted dispersive liquid-liquid microextraction, are reviewed according to the type of extraction solvents and dispersive methods. This paper also summarizes the application of DLLME to the analysis of biological samples in the last five years.

Key words: dispersive liquid-liquid microextraction (DLLME), extraction solvents, dispersive methods, biological samples, review

SHI Yiwei, ZHANG Ning, CAO Wen, HONG Zhanying. Advances in dispersive liquid-liquid microextraction and its application to analysis of biological samples[J]. Chinese Journal of Chromatography, 2020, 38(5): 491-501.

Figures/Tables 4

Fig. 1 Classification of DLLME and application to biological samples n-DLLME: normal dispersive liquid-liquid microextraction; IL-DLLME: ionic liquid dispersive liquid-liquid microextraction; DLLME-SFOD: dispersive liquid-liquid microextraction based on solidification of floating organic droplet; LDS-DLLME: low density solvent dispersive liquid-liquid microextraction; UA-DLLME: ultrasound-assisted dispersive liquid-liquid microextraction; VA-DLLME: vortex-assisted dispersive liquid-liquid microextraction; AA-DLLME: air-assisted dispersive liquid-liquid microextraction.

Fig. 2 Diagrams of the extraction processes of (a) n-DLLME, (b) DLLME-SFOD and (c) AA-DLLME

Fig. 3 Extraction procedure of AA-DLLME-SFOD-AALLME-SFOD

Table 1 Applications of DLLME to biological samples

References

1	Rezaee M , Assadi Y , Milani Hosseini M R , et al. J Chromatogr A, 2006, 1116 (1/2): 1
2	Mansour F R , Khairy M A . J Chromatogr B Analyt Technol Biomed Life Sci, 2017, 1061/1062: 382
3	Liu Y H , Chen P S , Huang S D . J AOAC Int, 2017, 100 (1): 212
4	Zhang J P , Jiang X D , Huang W , et al. Chinese Journal of Chromatography, 2018, 36 (5): 458
4	张吉苹, 蒋新娣, 黄薇, et al. 色谱, 2018, 36 (5): 458
5	Yan M M , Chen M , Meng X S , et al. Chinese Journal of Chromatography, 2018, 36 (8): 738
5	闫萌萌, 陈萌, 孟宪双, et al. 色谱, 2018, 36 (8): 738
6	Zhang M Y , Hong Z Y , Fan G R . Chinese Journal of New Drugs, 2011, 20 (5): 429
6	张明勇, 洪战英, 范国荣. 中国新药杂志, 2011, 20 (5): 429
7	Alcantara G K , Calixto L A , de Moraes L A , et al. J Anal Methods Chem, 2016, 2016: 1
8	Chen P S , Cheng Y H , Lin S Y , et al. Anal Bioanal Chem, 2016, 408 (2): 629
9	Gupta M K , Jain R , Singh P , et al. J Anal Toxicol, 2015, 39 (5): 365
10	Gong A , Zhu X . Spectrochim Acta A Mol Biomol Spectrosc, 2016, 159: 163
11	Arain S A , Kazi T G , Afridi H I , et al. Ecotoxicol Environ Saf, 2016, 126: 186
12	Maria K , Victoria S . Molecules, 2018, 23 (6): 1437
13	Mollahosseini A , Kamankesh M , Mohammadi A . J Chromatogr Sci, 2019, 57 (6): 575
14	Barfi B , Asghari A , Rajabi M , et al. J Pharm Biomed Anal, 2015, 111: 297
15	Leong M I , Fuh M R , Huang S D . J Chromatogr A, 2014, 1335: 2
16	Shirinnejad M , Sarrafi A H M . J Fluoresc, 2019, 29 (4): 1039
17	Iqbal M , Ezzeldin E , Khalil N Y , et al. J Pharm Biomed Anal, 2019, 164: 1
18	Wu C Q , Li Y , Chang S P , et al. Chinese Journal of Chromatography, 2018, 36 (5): 452
18	吴翠琴, 李颖, 常淑萍, et al. 色谱, 2018, 36 (5): 452
19	Ferrone V , Cotellese R , Carlucci M , et al. J Pharm Biomed Anal, 2018, 151: 266
20	Fernández P , Taboada V , Regenjo M , et al. J Pharm Biomed Anal, 2016, 124: 189
21	Malaei R , Ramezani A M , Absalan G . J Chromatogr B Analyt Technol Biomed Life Sci, 2018, 1089: 60
22	Shu M W , Leong M I , Fuh M R , et al. Analyst, 2012, 137 (9): 2143
23	Meng L , Zhu B , Zheng K , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2017, 1053: 9
24	Zhang K , Li S , Liu C , et al. J Sep Sci, 2019, 42 (2): 574
25	Akramipour R , Golpayegani M R , Gheini S , et al. Talanta, 2018, 86: 17
26	Rocha B A , de Oliveira A R M , Barbosa F Jr . Talanta, 2018, 183: 94
27	Rahmani M , Ghasemi E , Sasani M . Talanta, 2017, 165: 27
28	Lamei N , Ezoddin M , Abdi K . Talanta, 2017, 165: 176
29	Zhang K , Li S , Wang Y , et al. J Chromatogr A, 2020, 460876
30	Mohebbi A , Yaripour S , Farajzadeh M A , et al. J Chromatogr A, 2018, 1571: 84
31	Taheri S , Jalali F , Fattahi N , et al. J Sep Sci, 2015, 38 (2): 309
32	Mashayekhi H A , Khalilian F . J Chromatogr Sci, 2016, 54 (6): 1068
33	Zacharis C K , Tzanavaras P D . J Sep Sci, 2020, 43 (3): 631
34	Farahmand F , Ghasemzadeh B , Naseri A . Spectrochim Acta A Mol Biomol Spectrosc, 2018, 188: 72
35	Abujaber F , Corps Ricardo A I , Rios A , et al. J Pharm Biomed Anal, 2019, 165: 141
36	de Oliveira M L , Rocha B A , Souza V C O , et al. Talanta, 2019, 196: 271
37	Shen X , Liang J , Zheng L , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2018, 1096: 48
38	He Y , Zhao X E , Zhu S , et al. J Chromatogr A, 2016, 1458: 70
39	Vincenti F , Montesano C , Cellucci L . J Chromatogr A, 2019, 1065: 1
40	Talpur S , Kazi T G , Afridi H I , et al. J AOAC Int, 2018, 101 (3): 883
41	Rocha B A , da Costa B R , de Albuquerque N C . Talanta, 2016, 154: 511
42	Pastor-Belda M , Bastida D , Campillo N , et al. J Pharm Biomed Anal, 2016, 129: 458
43	Pastor-Belda M , Fernández-García A J , Campillo N , et al. J Chromatogr A, 2017, 1509: 43
44	Escrivá L , Manyes L , Font G , et al. Toxins (Basel), 2017, 9 (10): 330
45	Mercieca G , Odoardi S , Cassar M , et al. J Pharm Biomed Anal, 2018, 149: 494
46	Campillo N , Marín J , Fenoll J , et al. Talanta, 2017, 174: 638
47	Miekus N , Oledzka I , Plenis A , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2016, 1036/1037: 114
48	Li Y , Zhang W , Wang R G , et al. PLoS One, 2015, 10 (9): e0137194
49	Chen C H , Chao Y Y , Lin Y H , et al. J Chromatogr A, 2018, 1547: 14
50	Odoardi S , Fisichella M , Romolo F S , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 1000: 57
51	Konieczna L , Roszkowska A , Stachowicz-Stencel T , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2018, 1074/1075: 99
52	Jiménez-Díaz I , Iribarne-Durán L M , Ocón O , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2016, 1035: 57
53	Tabani H , Shokri A , Tizro S , et al. Talanta, 2019, 199: 329
54	De Boeck M , Dehaen W , Tytgat J , et al. J Forensic Sci, 2018, 63 (6): 1875
55	Meng L , Zhang W , Meng P , et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 989: 46
56	Sena L C , Matos H R , Dórea H S , et al. Toxicology, 2017, 376: 102
57	Pebdani A A , Shabani A M , Dadfarnia S , et al. J Sep Sci, 2016, 39 (10): 1935
58	Ahmadi-Jouibari T , Fattahi N , Shamsipur M , et al. J Pharm Biomed Anal, 2014, 94: 145
59	Wang Y , Zou X L , Zhang W T , et al. Chinese Journal of Analytical Chemistry, 2013, 41 (5): 749
59	王宇, 邹晓莉, 张文滔, et al. 分析化学, 2013, 41 (5): 749
60	Du X H , Xin X Y , Wang J P , et al. Journal of Hebei University (Natural Science Edition), 2018, 38 (6): 596
60	杜雪红, 辛晓莹, 王计彭, et al. 河北大学学报:自然科学版, 2018, 38 (6): 596
61	Zhao L , Zhao P , Wang L , et al. Biomed Chromatogr, 2014, 28 (6): 895
62	Li P , Cui J T , Guo X X , et al. Journal of Instrumental Analysis, 2018, 37 (3): 282
62	李佩, 崔君涛, 郭溪香, et al. 分析测试学报, 2018, 37 (3): 282
63	Ahmadi-Jouibari T , Fattahi N , Shamsipur M , et al. J Pharm Biomed Anal, 2013, 85: 14
64	Yuan Y , Wang Y , Yang M , et al. J Sep Sci, 2018, 41 (10): 2261
65	Cinelli G , Cuomo F , Ambrosone L , et al. Biotechnol Prog, 2019, 35 (3): e2780
66	Li Y , Hu J , Liu W , et al. Talanta, 2019, 195: 785

[1]	ZHOU Ranfeng, ZHANG Huixian, YIN Xiaoli, PENG Xitian. Progress in the application of novel nano-materials to the safety analysis of agricultural products [J]. Chinese Journal of Chromatography, 2023, 41(9): 731-741.
[2]	HUANG Jianying, XIA Ling, XIAO Xiaohua, LI Gongke. Advances in microchip electrophoresis for the separation and analysis of biological samples [J]. Chinese Journal of Chromatography, 2023, 41(8): 641-650.
[3]	WEN Yalun, SHAO Yuchen, ZHAO Xinying, QU Feng. Annual review of capillary electrophoresis technology in 2022 [J]. Chinese Journal of Chromatography, 2023, 41(5): 377-385.
[4]	XIE Weiya, ZHU Xiaohan, MEI Hongcheng, GUO Hongling, LI Yajun, HUANG Yang, QIN Hao, ZHU Jun, HU Can. Applications of functional materials-based solid phase microextraction technique in forensic science [J]. Chinese Journal of Chromatography, 2023, 41(4): 302-311.
[5]	OUYANG Yilan, YI Lin, QIU Luyun, ZHANG Zhenqing. Advances in heparin structural analysis by chromatography technologies [J]. Chinese Journal of Chromatography, 2023, 41(2): 107-121.
[6]	ZHAI Hongwen, MA Hongyu, CAO Meirong, ZHANG Mingxing, MA Junmei, ZHANG Yan, LI Qiang. Application progress of on-line sample preparation techniques coupled with liquid chromatography-mass spectrometry system in the detection of food hazards [J]. Chinese Journal of Chromatography, 2023, 41(12): 1062-1072.
[7]	YU Tao, CHEN Li, ZHANG Wenmin, ZHANG Lan, LU Qiaomei. Advances in synthesis methods and applications of microporous organic networks for sample preparation [J]. Chinese Journal of Chromatography, 2023, 41(12): 1052-1061.
[8]	WANG Guoxiu, CHEN Yonglei, LÜ Wenjuan, CHEN Hongli, CHEN Xingguo. Recent developments in the application of covalent organic frameworks in capillary electrochromatography [J]. Chinese Journal of Chromatography, 2023, 41(10): 835-842.
[9]	YAN Meiting, LONG Wenwen, TAO Xueping, WANG Dan, XIA Zhining, FU Qifeng. Research progress on the construction and applications of metal-organic frameworks in chromatographic stationary phases [J]. Chinese Journal of Chromatography, 2023, 41(10): 879-890.
[10]	SONG Chunying, JIN Gaowa, YU Dongping, XIA Donghai, FENG Jing, GUO Zhimou, LIANG Xinmiao. Development progress of stationary phase for supercritical fluid chromatography and related application in natural products [J]. Chinese Journal of Chromatography, 2023, 41(10): 866-878.
[11]	JIANG Wenqian, CHEN Yumei, BI Wentao. Synthesis of porous organic framework materials based on deep eutectic solvents and their application in solid-phase extraction [J]. Chinese Journal of Chromatography, 2023, 41(10): 901-910.
[12]	YANG Han, TANG Wenqi, ZENG Chu, MENG Shasha, XU Ming. Rational design of high performance metal organic framework stationary phase for gas chromatography [J]. Chinese Journal of Chromatography, 2023, 41(10): 853-865.
[13]	ZOU Xiaowei, LIU Xing, ZHANG Jianming. Advances in thin layer chromatography coupled with mass spectrometry technology [J]. Chinese Journal of Chromatography, 2023, 41(1): 24-36.
[14]	MAYIRA Abulitifu, ZHONG Zihao, BAI Xi. Progress in the application of preparative gas chromatography in separating volatile compounds [J]. Chinese Journal of Chromatography, 2023, 41(1): 37-46.
[15]	ZHAI Rongrong, GAO Wen, LI Mengning, YANG Hua. Applications of ion mobility-mass spectrometry in the chemical analysis in traditional Chinese medicines [J]. Chinese Journal of Chromatography, 2022, 40(9): 782-787.