Research progress on the fragmentation mechanisms of mass spectrometry soft ionization and screening of chemical hazardous substances in food

doi:10.3724/SP.J.1123.2020.03002

Abstract

Abstract:

Hazardous chemicals in food are an important cause of food safety problems. Mass spectrometry is an effective tool for the qualitative and quantitative analysis of these substances. In this paper, the fragmentation mechanisms for several chemical hazardous substances, including pesticides, veterinary drugs, mycotoxins, and other chemical pollutants classified by structural analogs, are reviewed. For each class of compounds, we summarize the characteristic fragments and neutral loss generated by cleavage in the mass spectrometry analysis. We also summarize the mechanisms applied to screen and discover new structural analogs in food. This review can help researchers analyze and confirm the structure of compounds and provide a theoretical basis for the discovery of new structural analogs in food.

Key words: fragmentation mechanisms, soft ionization technique, mass spectrometry, characteristic fragments, untargeted screening, unknown compounds, review

LIU Xiaomin, XU Xiuli, NIE Xuemei, GUO Wei, ZHANG Feng. Research progress on the fragmentation mechanisms of mass spectrometry soft ionization and screening of chemical hazardous substances in food[J]. Chinese Journal of Chromatography, 2020, 38(7): 750-758.

Figures/Tables 4

Fig. 1 Fragmentation mechanisms of mass spectrometry soft ionization of the typical pesticides -----: main bond cleavage of compounds.

Fig. 2 Fragmentation mechanisms of mass spectrometry soft ionization of typical veterinary drugs

Fig. 3 Fragmentation mechanisms of mass spectrometry soft ionization of typical mycotoxins

Fig. 4 Fragmentation mechanisms of mass spectrometry soft ionization of other chemical pollutants

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